Microemulsions for oral administration and their therapeutic applications

Gibaud, Stéphane; Attivi, David

doi:10.1517/17425247.2012.694865

Cited by 70 publications

(42 citation statements)

References 98 publications

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“…The preparation of selected microemulsion was simply performed by adding the weighed components together and stirring to form a clear microemulsion. [1718]…”

Section: Methodsmentioning

confidence: 99%

Formulation and evaluation of microemulsion-based hydrogel for topical delivery

Sabale

Vora

2012

Int J Pharma Investig

135

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Background:The purpose of this study was to develop microemulsion-based hydrogel formulation for topical delivery of bifonazole with an objective to increase the solubility and skin permeability of the drug.Materials and Methods:Oleic acid was screened as the oil phase of microemulsions, due to a good solubilizing capacity of the microemulison systems. The pseudo-ternary phase diagrams for microemulsion regions were constructed using oleic acid as the oil, Tween 80 as the surfactant and isopropyl alcohol (IPA) as the cosurfactant. Various microemulsion formulations were prepared and optimized by 32 factorial design on the basis of percentage (%) transmittance, globule size, zeta potential, drug release, and skin permeability. The abilities of various microemulsions to deliver bifonazole through the skin were evaluated ex vivo using Franz diffusion cells fitted with rat skins. The Hydroxy Propyl Methyl Cellulose (HPMC) K100 M as a gel matrix was used to construct the microemulsion-based hydrogel for improving the viscosity of microemulsion for topical administration. The optimized microemulsion-based hydrogel was evaluated for viscosity, spreadability, skin irritancy, skin permeability, stability, and antifungal activity by comparing it with marketed bifonazole cream.Results:The mechanism of drug release from microemulsion-based hydrogel was observed to follow zero order kinetics. The studied optimized microemulsion-based hydrogel showed a good stability over the period of 3 months. Average globule size of optimized microemulsion (F5) was found to be 18.98 nm, zeta potential was found to be -5.56 mv, and permeability of drug from microemulsion within 8 h was observed 84%. The antifungal activity of microemulsion-based hydrogel was found to be comparable with marketed cream.Conclusion:The results indicate that the studied microemulsion-based hydrogel (F5) has a potential for sustained action of drug release and it may act as promising vehicle for topical delivery of ibuprofen.

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“…The preparation of selected microemulsion was simply performed by adding the weighed components together and stirring to form a clear microemulsion. [1718]…”

Section: Methodsmentioning

confidence: 99%

Formulation and evaluation of microemulsion-based hydrogel for topical delivery

Sabale

Vora

2012

Int J Pharma Investig

135

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“…Emulsion technology is utilized in a wide variety of industries including the cosmetics, agriculture, food and pharmaceutics (27). ME solutions were recognized in 1943 when Hoar and Schulman mixed a milky solution with hexanol to produce a uniform single-phase, non-conducting solution (28). MEs are clear and thermodynamically stable mixtures of oil and water A, Normal control group, normal morphology of histological section of mice liver; B, positive control group, 24 hours after the injection of CCL4.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Microemulsion-Based System of Prunus Cerasus Kernel Extract on CCL4-induced Liver Damage in Mice

Kalantari‬

Salimi

Motaharitabar

et al. 2017

Jundishapur J Nat Pharm Prod

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“…Here, soluble metal salts (Fe 2+ /Fe 3+ ) are incorporated into aqueous microdroplets in oil that coalesce with hydroxide (OH − )-containing microdroplets to form magnetite-containing microdroplets. Particle size is a function of interdroplet exchange and nuclei aggregation is affected by reaction temperature [45,46]. MNP synthesis by microemulsion can be accelerated by increased temperature [47].…”

Section: Formulation Developments and Product Synthesismentioning

confidence: 99%

Formulation Design Facilitates Magnetic Nanoparticle Delivery to Diseased Cells and Tissues

et al. 2014

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Magnetic nanoparticles (MNPs) accumulate at disease sites with the aid of magnetic fields; biodegradable MNPs can be designed to facilitate drug delivery, influence disease diagnostics, facilitate tissue regeneration and permit protein purification. Because of their limited toxicity, MNPs are widely used in theranostics, simultaneously facilitating diagnostics and therapeutics. To realize therapeutic end points, iron oxide nanoparticle cores (5–30 nm) are encapsulated in a biocompatible polymer shell with drug cargos. Although limited, the toxic potential of MNPs parallels magnetite composition, along with shape, size and surface chemistry. Clearance is hastened by the reticuloendothelial system. To surmount translational barriers, the crystal structure, particle surface and magnetic properties of MNPs need to be optimized. With this in mind, we provide a comprehensive evaluation of advancements in MNP synthesis, functionalization and design, with an eye towards bench-to-bedside translation.

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Microemulsions for oral administration and their therapeutic applications

Cited by 70 publications

References 98 publications

Formulation and evaluation of microemulsion-based hydrogel for topical delivery

Formulation and evaluation of microemulsion-based hydrogel for topical delivery

Hepatoprotective Effect of Microemulsion-Based System of Prunus Cerasus Kernel Extract on CCL4-induced Liver Damage in Mice

Formulation Design Facilitates Magnetic Nanoparticle Delivery to Diseased Cells and Tissues

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