Microencapsulation of Insulin Microcrystals

Insulin Loaded PLGA Microspheres: Effect of Zinc Salts on Encapsulation, Release, and Stability

“…Insulin is one of the most widely investigated proteins to be encapsulated into PLGA microspheres 6–10. Several straightforward strategies have been proposed to address the above mentioned challenges with insulin.…”

Microcrystallization of α-lactalbumin

“…[19]. In addition, in the pharmaceutical field micron-sized crystals are applicable for poorly water-soluble drugs [20], suspension injection [21], and pulmonary inhalation delivery [22][23][24]. The crystallinity of the spherical microcrystals which we obtained was investigated by the X-ray diffractometry and differential scanning calorimetry.…”

The effect of coencapsulation of bovine insulin with cyclodextrins in ethylcellulose microcapsules

“…Encapsulation of insulin within various materials including: poly(lactide-co-glycolide) (Barichello et al 1999;Rosa et al 2000;Shao and Bailey 2000;Yamaguchi et al 2002;Pan et al 2003;Choi et al 2004), poly(isobutylcyanoacrylate) (Roques et al 1992;Aboubakar et al 1999;Cournarie et al 2004), polymethacrylate (Agarwal et al 2001), alginate (Onal and Zihnioglu 2002;Raj and Sharma 2003), chitosan (Ma et al 2002;Onal and Zihnioglu 2002;Pan et al 2003) and liposomes (Spangler 1990;Griaznova et al 1992;Kato et al 1993) have been investigated previously. Inherent problems such as acidic microenvironment, low encapsulation efficiency, undesirable release profiles, and low recovery of active protein were observed in insulin formulations, suggesting the need for additional investigation.…”