2023
DOI: 10.34133/space.0008
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Microfluidic Actuated and Controlled Systems and Application for Lab-on-Chip in Space Life Science

Abstract: The use of space environment to carry out life science research is of great significance. However, there are limitations in complex manipulation, research models based on mammalian and 2-dimensional cell culture experiments, etc. Microfluidic chips possess the characteristics of integrating the relevant functions of traditional laboratories into micron-scale chips, with low energy consumption, high throughput, and automation. The application of microfluidic chips can overcome the challenges of space environmen… Show more

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Cited by 14 publications
(5 citation statements)
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“…Thus, by flexibly designing microfluidic chips that combine multiple cell types and specific biological structures, on-chip co-culture of multiple cells can not only achieve the functions of traditional methods but also has the potential to construct microphysiological systems (MPS) with key functionalities of more complex target organs, 9,10 such as critical tissue interfaces, spatiotemporal cell-cell/extracellular matrix interactions, concentration gradients of nutrients, metabolic waste, and cytokines, as well as immune microenvironments. 11,12 Additionally, on-chip observation of cells cultured in different regions allows for obtaining specific and clear information about the concentration distribution of biomolecules or cytokines, providing more precise and detailed means for biological research. [13][14][15][16] These chips or chip systems can provide deterministic and reproducible simulated scenarios, enabling reliable studies of cellular behaviors in environments that mimic mechanical forces in living tissues.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, by flexibly designing microfluidic chips that combine multiple cell types and specific biological structures, on-chip co-culture of multiple cells can not only achieve the functions of traditional methods but also has the potential to construct microphysiological systems (MPS) with key functionalities of more complex target organs, 9,10 such as critical tissue interfaces, spatiotemporal cell-cell/extracellular matrix interactions, concentration gradients of nutrients, metabolic waste, and cytokines, as well as immune microenvironments. 11,12 Additionally, on-chip observation of cells cultured in different regions allows for obtaining specific and clear information about the concentration distribution of biomolecules or cytokines, providing more precise and detailed means for biological research. [13][14][15][16] These chips or chip systems can provide deterministic and reproducible simulated scenarios, enabling reliable studies of cellular behaviors in environments that mimic mechanical forces in living tissues.…”
Section: Introductionmentioning
confidence: 99%
“…To achieve this goal, it is critical to acquire and analyze sufficient biological and physiopathological information from patients and utilize instructive medical data to realize patient-specific therapy. Advanced devices for healthcare such as medical nano/microrobot, wearable/implantable biosensors, and human organ-on-chips (OOCs) have emerged in recent years, allowing for the target delivery of drugs/cells, precise monitoring of physiological conditions, and evaluation of patients’ responses toward customized pharmaceutic combinations [ 4 8 ]. Despite this, the design and manufacturing of these sophisticated instruments necessitate innovations in engineering techniques.…”
Section: Introductionmentioning
confidence: 99%
“…Labs-on-a-chip (LOCs), also known as microfluidic devices, have revolutionized biomedical and chemical analysis by providing efficient, portable, and highly miniaturized solutions ( Najjar et al, 2022 ; Izadifar et al, 2023 ; Zhao et al, 2023 ). The microfluidic design of these devices enables precise control of fluid flows and processes, leading to improved accuracy and repeatability of results ( Karthik et al, 2022 ; Verma & Pandya, 2022 ).…”
Section: Introductionmentioning
confidence: 99%