Microfluidic integration of wirebonded microcoils for on-chip applications in nuclear magnetic resonance

Meier, R.; Höfflin, Jens; Badilita, Vlad; Wallrabe, Ulrike; Korvink, Jan G.

doi:10.1088/0960-1317/24/4/045021

Cited by 36 publications

(25 citation statements)

References 62 publications

(115 reference statements)

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“…Letters a-t correspond to di erent authors as cited by Badilita et al [5]. Data points u [23] and v [10] represent more recent work. The performance of the optimised probe presented here is shown in red, along with a similar, earlier prototype that had not been numerically optimised (blue).…”

Section: Performance Characterisationmentioning

confidence: 99%

An optimised detector for in-situ high-resolution NMR in microfluidic devices

Finch

Yılmaz

Utz

2016

Journal of Magnetic Resonance

109

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Integration of high-resolution nuclear magnetic resonance (NMR) spectroscopy with microfluidic lab-on-a-chip devices is challenging due to limited sensitivity and line broadening caused by magnetic susceptibility inhomogeneities. We present a novel double-stripline NMR probe head that accommodates planar microfluidic devices, and obtains the NMR spectrum from a rectangular sample chamber on the chip with a volume of 2 l. Finite element analysis is used to jointly optimise the detector and sample volume geometry for sensitivity and RF homogeneity. A prototype of the optimised design has been built, and its properties have been characterised experimentally. The performance in terms of sensitivity and RF homogeneity closely agrees with the numerical predictions. The system reaches a mass limit of detection of 1.57 nMol p s, comparing very favourably with other micro-NMR systems. The spectral resolution of this chipGprobe system is better than 1.75 Hz at a magnetic field of 7 T, with excellent line shape.

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Section: Performance Characterisationmentioning

confidence: 99%

An optimised detector for in-situ high-resolution NMR in microfluidic devices

Finch

Yılmaz

Utz

2016

Journal of Magnetic Resonance

109

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“…In the context of MR, high‐Q (> 10 000) off‐chip capacitors are usually used as tuning and matching elements for NMR coils. These are either soldered to a PCB and connected to the coil via transmission lines, or connected directly to the leads of the coil wire . Unfortunately, the size of discrete soldered capacitors (smallest one being 1.8 mm × 1 mm × 0.8 mm) hinders further miniaturization of the NMR detector.…”

Section: Limitations Imposed By the Electrical Performancementioning

confidence: 99%

“…After more than 2 decades, this still represents one of the best results in the field. Successful MR detector miniaturization has triggered additional developments, such as the integration of microfluidic channels in order to be able to handle and deliver sub‐μL samples, and the integration of spectrometer electronics in order to bring the pre‐amplifying capabilities closer to the sample, that is, closer to the detection point, an essential measure when dealing with even weaker signals originating from these minute samples.…”

Section: Introductionmentioning

confidence: 99%

Capacitor re‐design overcomes the rotation rate limit of MACS resonators

Adhikari

Wallrabe

Badilita

et al. 2017

Concepts Magn Reson

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The magic angle coil spinning (MACS) technique has provided a breakthrough in enhancing sensitivity in magic angle spinning (MAS) NMR. However, efforts in improving the MACS detector for higher spinning speeds have been lacking. One published MACS construction technique is to solder a handwound solenoidal coil to a commercial non-magnetic capacitor and subsequently centering the detector inside the MAS rotor. An alternative method to realize these detectors is by using MEMS fabrication at the wafer scale, potentially capable of achieving reproducible MACS detectors. However, it is also important that the performance of the sensors does not deteriorate as a result of microfabrication constraints. The footprint of the detectors is a limiting factor in achieving higher spinning speeds. One of the key elements of a micro-resonator is its tuning capacitor, whose geometry has a significant influence on its electrical and mechanical performance. The quality factor of the capacitor, along with the induced eddy currents, are the key performance parameters considered. The article addresses these concerns by presenting a study of microfabricated on-chip capacitors for magic angle coil spinning (MACS) detectors. The capacitors are juxtaposed with commercially available capacitors and the most suitable fit to be integrated with a micro-coil is established.K E Y W O R D S eddy currents, magic angle coil spinning, MEMS fabrication, quality factor

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“…MRI and NMR uses strong time-varying radio frequency (RF) fields to generate a weak specific RF response from a certain tissue type [129]. Because the technology is noninvasive and only nonionizing radiation is absorbed and emitted, it might be especially suitable for the study of C. elegans in the identification and quantification of metabolites (intermediate products of metabolism) within the metabolic pathway in vivo [130][131][132][133][134][135][136].…”

Section: Discussionmentioning

confidence: 99%

Advanced Microfluidic Assays for Caenorhabditis elegans

Bakhtina¹,

MacKinnon²,

Korvink³

2016

Advances in Microfluidics - New Applications in Biology, Energy, and Materials Sciences

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The in vivo analysis of a model organism, such as the nematode Caenorhabditis elegans, enables fundamental biomedical studies, including development, genetics, and neurobiology. In recent years, microfluidics technology has emerged as an attractive and enabling tool for the study of the multicellular organism. "dvances in the application of microfluidics to C. elegans assays facilitate the manipulation of nematodes in high-throughput format and allow for the precise spatial and temporal control of their environment. In this chapter, we aim to illustrate the current microfluidic approaches for the investigation of behavior and neurobiology in C. elegans and discuss the trends of future development.Keywords: C. elegans, chip-based, manipulation, microfluidics, model organism . IntroductionThe invertebrate Caenorhabditis elegans, Drosophila melanogaster, and the vertebrate zebrafish Danio rerio are the most widely studied multicellular organisms. The in vivo analysis of these model organisms allows the understanding of many complex physiological processes, addressing many of the questions relevant to human biology. The choice of model organism depends on the biological question under investigation. For example, C. elegans is simple enough to be experimentally tractable. It has a short life cycle days at °C and lifespan days at °C , passes through four larva L L stages and an adult stage [ ]. Its small size . mm long and µm wide , transparent body at all life stages, and preferred food source Escherichia coli simplify its maintenance on agar plates or liquid cultures allowing visualization of individual cells and organs in intact animals. C. elegans possesses one of the simplest central nervous systems the adult hermaphrodite has neurons . "ecause it is so well studied, rapid identification of signaling pathways, for instance, in studies of aging, has © 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. become possible. "bout % of human disease genes have an orthologue in the genome of C. elegans, including those genes associated with "lzheimer disease, Parkinson's disease, Huntington's disease HD , and many other neurodegenerative disorders [ ]. This astonishing degree of correspondence permits the modeling of human ailments in a simple invertebrate without involving actual human subjects and provides a meaningful insight into the pathogenesis of a complex disease phenotype.Traditionally, behavioral genetics is employed as a prime method for neurobiological studies in C. elegans. It is based on manual worm manipulation on a Petri dish or a multiwell plate, and monitoring the effects on various biological processes, such as growth and fertility, by visual inspection. Refreshment of old buffer solutions by a fresh solution is invasive and causes stress both to the lar...

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Microfluidic integration of wirebonded microcoils for on-chip applications in nuclear magnetic resonance

Cited by 36 publications

References 62 publications

An optimised detector for in-situ high-resolution NMR in microfluidic devices

An optimised detector for in-situ high-resolution NMR in microfluidic devices

Capacitor re‐design overcomes the rotation rate limit of MACS resonators

Advanced Microfluidic Assays for Caenorhabditis elegans

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