Microgels and hydrogels as delivery systems for antimicrobial peptides

Borro, Bruno C.; Nordström, Randi; Malmsten, Martin

doi:10.1016/j.colsurfb.2020.110835

Cited by 43 publications

(32 citation statements)

References 56 publications

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“…The main strategies include (1) constructing precursors to reduce cytotoxicity and improve protease stability, (2) using AMPs in combination with existing antibacterial agents, (3) inducing the correct expression of AMPs with appropriate drugs and using engineering probiotics as vectors to express AMPs. For example, in the field of wound repair, different formulation strategies, such as loading AMPs in nanoparticles, hydrogels, creams, gels, ointments, or glutinous rice paper capsules, have been developed to effectively deliver AMPs to the wound (Borro et al, 2020;Thapa et al, 2020). In recent research, the sponges developed from modified starch and HS-PEG-SH are covalently immobilized with AMP showed effective antibacterial activity (Yang et al, 2019).…”

Section: Current Progress and Application Of Antimicrobial Peptides Mmentioning

confidence: 99%

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

et al. 2020

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Antimicrobial peptides (AMPs) are a class of small peptides that widely exist in nature and they are an important part of the innate immune system of different organisms. AMPs have a wide range of inhibitory effects against bacteria, fungi, parasites and viruses. The emergence of antibiotic-resistant microorganisms and the increasing of concerns about the use of antibiotics resulted in the development of AMPs, which have a good application prospect in medicine, food, animal husbandry, agriculture and aquaculture. This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved. The research progress on antivirus peptides, especially anti-coronavirus (COVID-19) peptides, has been introduced given the COVID-19 pandemic worldwide in 2020.

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Section: Current Progress and Application Of Antimicrobial Peptides Mmentioning

confidence: 99%

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

et al. 2020

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“…Hydrogels have been used also to deliver antimicrobial peptides (AMPs), which are one of the most well-studied classes of biofilm eradication agents [105,106]. AMPs are a diverse group of host-defense molecules that include defensins, cathelicidins, histatins, neuropeptides, peptide hormones, and many other proven and putative peptides.…”

Section: Hydrogelsmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan²,

Akca

2021

Drug Deliv. and Transl. Res.

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Oral health reflects the general health, and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection-related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed, and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

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“…Hydrogels have been used also to deliver antimicrobial peptides (AMPs), which are one of the most well-studied classes of bio lm eradication agents [101,102]. AMPs are a diverse group of host-defense molecules that include defensins, cathelicidins, histatins, neuropeptides, peptide hormones, and many other proven and putative peptides.…”

Section: Micellesmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan

2021

Preprint

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Oral health reflects the general health and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

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Microgels and hydrogels as delivery systems for antimicrobial peptides

Cited by 43 publications

References 56 publications

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

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