Microglandular adenocarcinoma of the uterus mimicking microglandular cervical hyperplasia

Zámečnı́k, Michal; Skálová, Alena; Opatrný, Václav

doi:10.1016/s1092-9134(03)00018-2

Cited by 18 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mild to moderate nuclear atypia and low mitotic activity (b1/10 HPF) were also common features among their cases. Additional endometrial carcinoma cases with similar morphological features have been subsequently reported by other authors emphasizing their architectural similarity to MGH, deceptively bland cytologic appearance and low mitotic activity [9,[24][25][26][27][28]. Zaloudek et al [9] coined the term microglandular adenocarcinoma for EACs with prominent microglandular changes mimicking MGH.…”

Section: Discussionmentioning

confidence: 76%

Diagnostic application of KRAS mutation testing in uterine microglandular proliferations

et al. 2015

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 76%

Diagnostic application of KRAS mutation testing in uterine microglandular proliferations

et al. 2015

View full text Add to dashboard Cite

“…4,5 Two of the patients were obese, including the current case. 4 In the assessment of endometrial curettage specimens of the cases that formerly reported, six of them were misinterpreted as benign or uncertain histology whether benign or malignant. 1 Two of cases were misdiagnosed as MGH.…”

Section: Discussionmentioning

confidence: 85%

“…These findings support the idea that the microglandular pattern represents a line of differentiation that is more mature and less aggressive in comparison with conventional carcinoma and this microglandular pattern usually occurs on the tumor surface where an area permits a proliferation of noninvasive cells. 4 The studies of Young and Scully and Fukunaga supported this argument but Zaloudek et al and McCluggage found MGH-like patterns in invasive areas of the tumor. 1,6,7,13 Contrary to all of them we found only MGH-like carcinoma in superficial layer of the endometrium in the hysterectomy specimen.…”

Section: Discussionmentioning

confidence: 97%

Microglandular Adenocarcinoma of the Endometrium: Case Report

Doğan¹,

Sayar²,

Grover³

et al. 2016

Turkiye Klinikleri J Gynecol Obst

View full text Add to dashboard Cite

114ucinous microglandular adenocarcinoma (MGA) is an uncommon subtype of endometrial adenocarcinoma which can be confused with mucinous adenocarcinoma (MUC-AD) and microglandular hyperplasia of the cervix or mucinous proliferations of the endometrium. [1][2][3] This neoplasm can mimic microglandular hyperplasia (MGH) particularly, which is characterized by closely packed glands lined by cuboidal or columMicroglandular Adenocarcinoma of the Endometrium: Case Report A AB BS ST TR RA AC CT T We report a case of endometrial microglandular adenocarcinoma which can be confused with microglandular hyperplasia and mucinous adenocarcinoma of the cervix and mucinous proliferation of the endometrium. A 54-year-old postmenopausal woman presented with vaginal bleeding. Histologically, endometrial biopsy was characterized by closely packed microglandular and mucinous glandular areas, which is lined by cuboidal and columnar cells. There was a multitude of neutrophils in microglandular lumens and stroma. Immunohistochemically, focal positivity for vimentin, CEA, estrogen and progesterone receptors were seen. The histology was suspicious for malignancy that might be compatible with microglandular adenocarcinoma of the endometrium resembling microglandular hyperplasia of the cervix. In the final workout of the hysterectomy specimen, we determined a superficial microglandular adenocarcinoma with no myometrial invasion. Several tubal, eosinophilic syncytial and squamous metaplasia areas were present. Pathologists require sufficient clinical information, morphologic experience and immunohistochemical assistance to make the correct pathological diagnosis in such confounding neoplasms. A An na ah ht ta ar r K Ke el li im me el le er r: : Endometriyal tümörler; adenokarsinom; hiperplazi; metaplazi T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J G Gy yn ne ec co ol l O Ob bs st t 2 20 01 16 6; ;2 26 6( (2 2) ): :1 11 14 4--8 8

show abstract

“…In addition, both MGH and EAC may have foci of squamous differentiation, as well as intraluminal mucin with neutrophils. Rare EACs with a microglandular pattern have also been described in the literature and termed ''microglandular adenocarcinoma,'' as many of the reported cases were initially misdiagnosed as benign cervical MGH (10)(11)(12)(13)(14)20,21). Traditionally, presence of nuclear atypia and mitotic activity have been emphasized as diagnostic clues in favor of EAC, however, well-differentiated mucinous or endometrioid EAC often has deceptively bland nuclei and relatively low mitotic index.…”

Section: Mitotically Active Microglandular Hyperplasiamentioning

confidence: 99%

“…Small fragments of cervical MGH may mimic microglandular adenocarcinoma of the endometrium, especially when present in the endometrial biopsy or curettage (5,10). Conversely, endometrial microglandular, mucinous or endometrioid adenocarcinomas may be misdiagnosed in small, fragmented specimens as cervical MGH as a result of their overlapping morphologic features (5,(10)(11)(12)(13)(14). Increased mitotic activity in MGH may also raise the possibility of cervical dysplasia or endocervical adenocarcinoma in the differential diagnosis.…”

mentioning

confidence: 99%

Mitotically Active Microglandular Hyperplasia of the Cervix

Abi‐Raad

Al‐Omari

Hui

et al. 2014

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

Microglandular hyperplasia (MGH) is a benign proliferation of endocervical glands with relatively uniform columnar or cuboidal nuclei, and rare to absent mitoses. Endometrial adenocarcinomas with mucinous differentiation or a microglandular pattern can closely mimic MGH, often resulting in a diagnostic dilemma in small biopsy specimens. Rare unusual morphologic features-mild to moderate nuclear atypia, solid or reticular growth pattern, hobnail and signet ring cells-have been previously reported in MGH. We present 9 cases of unusual, mitotically active-between 5 and 11 mitotic figures per 10 HPF-MGH, all of which presented as endocervical polyps and had morphologic features otherwise typical of MGH. The patients' age ranged between 35 and 56 yr, 2 patients were postmenopausal. High-risk human papillomavirus status was available in 7 patients, all of which were negative. The Ki-67 proliferation index ranged between 1% and 15%, and all cases were negative for p16, carcinoembryonic antigen, and vimentin immunostains. The clinical follow-up ranged from 3 to 76.2 mo, with a median of 40.7 mo, all patients were doing well without evidence of endocervical or endometrial malignancy. In summary, this case series documents the presence of rare cases of MGH demonstrating significant mitotic activity (up to 11/10 HPF) without a negative impact on the clinical prognosis. Mitotic activity alone should be interpreted with caution in small biopsy specimens with microglandular growth pattern. Immunohistochemical stains, especially p16, carcinoembryonic antigen, and vimentin, may be helpful-in addition to the patient's clinical history and human papillomavirus status to rule out endocervical or endometrial malignancy.

show abstract

Microglandular adenocarcinoma of the uterus mimicking microglandular cervical hyperplasia

Cited by 18 publications

References 24 publications

Diagnostic application of KRAS mutation testing in uterine microglandular proliferations

Diagnostic application of KRAS mutation testing in uterine microglandular proliferations

Microglandular Adenocarcinoma of the Endometrium: Case Report

Mitotically Active Microglandular Hyperplasia of the Cervix

Contact Info

Product

Resources

About