Micromechanical measurement of adhesion of dehydrating silicone hydrogel contact lenses to corneal tissue

Zhu, Dongkai; Liu, Yangping; Gilbert, Jeremy L.

doi:10.1016/j.actbio.2021.03.053

Cited by 15 publications

(8 citation statements)

References 48 publications

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“…Compared with similar published works [ 3 , 33 ], this present work found that the F ad values of the cornea were smaller than the previous studies by one or two orders of magnitude. This is because the contact areas observed here, between the cornea and the punch, were much smaller than previous works related to corneas contacted with artificial corneas or contact lenses.…”

Section: Discussioncontrasting

confidence: 87%

“…The cornea, a transparent organ, forms the anterior pole of the eye, and it plays an essential role in visual function [ 1 ]. Adhesion behavior by the cornea is often accompanied with ophthalmic clinical treatments such as wearing contact lenses for correcting myopia [ 2 , 3 ]. After refractive surgeries, the stabilization of the postoperative cornea depends on the corneal cap firmly adhering to the residual stromal bed [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, employing the JKR model, recently Zhu and colleagues studied and compared the adhesion interactions between the cornea and silicone contact lenses of different types [ 3 ]. Their work focused on the interfacial adhesion interaction between the two different soft materials and, thus, the obtained adhesion force was coupled together with contributions from the two soft materials.…”

Section: Introductionmentioning

confidence: 99%

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Corneal Adhesion Possesses the Characteristics of Solid and Membrane

et al. 2022

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Adhesion behavior usually occurs in corneas associated with clinical treatments. Physiologically, an intact natural cornea is inflated by intraocular pressure. Due to the inflation, the physiological cornea has a mechanical property likeness to membrane. This characteristic is ignored by the classical theory used to analyze the adhesion behavior of soft solids, such as the Johnson–Kendall–Roberts (JKR) model. Performing the pull-off test, this work evidenced that the classical JKR solution was suitable for computing the corneal adhesion force corresponding to the submillimeter scale of contact. However, when the cornea was contacted at a millimeter scale, the JKR solutions were clearly smaller than the related experimental data. The reason was correlated with the membranous characteristic of the natural cornea was not considered in the JKR solid model. In this work, the modified JKR model was superimposed by the contribution from the surface tension related to the corneal inflation due to the intraocular pressure. It should be treated as a solid when the cornea is contacted at a submillimeter scale, whereas for the contact at a larger size, the characteristic of the membrane should be considered in analyzing the corneal adhesion. The modified JKR model successfully described the adhesion characteristics of the cornea from solid to membrane.

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Section: Discussioncontrasting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Corneal Adhesion Possesses the Characteristics of Solid and Membrane

et al. 2022

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“…People use the mechanical support and delivery carrier characteristics of hydrogels to fully stimulate and improve the self‐repairing ability of the human body by endowing the hydrogel materials with different biological structures and functions 22 . Hydrogels have been widely used in different tissue repairs, such as chronic wound skin tissue, 26 damaged heart tissue, 18 brain nerve tissue, 27 bone tissue, 28,29 and corneal tissue 30 . With the deepening of research, it has been found that functional molecules such as drugs or proteins encapsulated in traditional hydrogels have the disadvantage of uncontrollable release at the site of tissue damage.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in smart‐responsive hydrogels for tissue repairing

Yang

Wang

2022

MedComm – Biomaterials and Applications

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The rapid development of biomedical materials and tissue engineering technology has played an increasingly important role in the process of tissue repair in recent years. Smart-responsive hydrogels are three-dimensional network structures formed by cross-linking of hydrophilic polymers. In addition to having conventional hydrogels that approximate the natural extracellular matrix structure and serve as delivery vehicles for functional molecules (drugs and proteins). More importantly, smart-responsive hydrogels can achieve relevant changes in material morphology or properties under the conditions of changes in physical, chemical, and biological factors, thereby achieving controlled functional molecules release. It is more urgent to design and build smart-responsive hydrogels to achieve precise tissue repair with the introduction of the concept of precision medicine and drug delivery. In this review, we highlight different types of smart-responsive hydrogels and their mechanisms of response to different stimuli and discuss their potential for application in different types of tissue repair, such as chronic wound repair, damaged heart tissue repair, brain nerve tissue repair, and other fields. Finally, we present the prospects of smart-responsive hydrogels in tissue repair. In general, the current progress in the application of smart-responsive hydrogels in tissue repair lays the foundation for future applications in other diseases.

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“…Contact lenses (CLs) are convenient medical devices used for vision correction and cosmetic purposes. − However, long-term wear of CLs can lead to protein absorption and associated bacterial infection, − which are formidable threats to ophthalmic health. On one hand, proteins in tear fluid can readily adhere to CLs, resulting in reduced transparency and discomfort .…”

Section: Introductionmentioning

confidence: 99%

Nonfouling and Antibacterial Zwitterionic Contact Lenses Loaded with Heme-Mimetic Gallium Porphyrin for Treating Keratitis

Zhang

et al. 2022

Langmuir

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Antifouling and antibacterial are two critical challenges in the development of contact lenses (CLs). Herein, we presented nonfouling and antibacterial bifunctionalized CLs by encapsulating cationic heme-mimetic gallium porphyrin (Ga-CHP) into zwitterionic-elastomeric-networked (ZEN) hydrogel. Results proved that the ZEN hydrogel showed excellent abilities to resist non-specific protein adsorption, bacterial adhesion, and biofilm formation. Moreover, Ga-CHP could be sustainably released and kill >99.9% planktonic bacteria and >99.9% mature biofilms. In vivo, the symptoms of bacterial keratitis in mice were significantly alleviated after wearing the CLs for 7 days via ironblocking and photodynamic synergistic antibacterial therapy with the help of natural sunlight. This study highlights the nonfouling and antibacterial superiority of the Ga-CHP-functional zwitterionic CLs and proposes a portable yet efficient non-antibiotic keratitis treatment strategy.

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Micromechanical measurement of adhesion of dehydrating silicone hydrogel contact lenses to corneal tissue

Cited by 15 publications

References 48 publications

Corneal Adhesion Possesses the Characteristics of Solid and Membrane

Corneal Adhesion Possesses the Characteristics of Solid and Membrane

Recent advances in smart‐responsive hydrogels for tissue repairing

Nonfouling and Antibacterial Zwitterionic Contact Lenses Loaded with Heme-Mimetic Gallium Porphyrin for Treating Keratitis

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