2008
DOI: 10.1002/anie.200800810
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Micrometer‐Scale Protein‐Resistance Gradients by Electron‐Beam Lithography

Abstract: Sticky slope: The irradiation‐promoted exchange reaction on monolayers using ethylene glycol terminated thiols as ligands provides a useful tool for the adjustment of the bioresistance of surfaces. In conjunction with electron‐beam lithography, micrometer‐scale gradients of protein adhesivity could be produced (see picture: AFM=atomic force microscopy).

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Cited by 33 publications
(48 citation statements)
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“…Subsequently, polymer brushes were grown by surface‐initiated atom transfer radical polymerization (SI‐ATRP). Due to the steric effect, polymer chains at high surface‐density areas were taller than those at low surface‐density areas, resulting in the formation of 3D polymer brushes . Finally, the 3D polymer brushes were used as resists to form 3D Au structures by cycles of alternative plasma etching of the polymer and wet etching of Au, in which the lateral geometry was defined by poly(methyl methacrylate) (PMMA) brushes and height of each step was controlled by the etching conditions.…”
Section: Methodsmentioning
confidence: 99%
“…Subsequently, polymer brushes were grown by surface‐initiated atom transfer radical polymerization (SI‐ATRP). Due to the steric effect, polymer chains at high surface‐density areas were taller than those at low surface‐density areas, resulting in the formation of 3D polymer brushes . Finally, the 3D polymer brushes were used as resists to form 3D Au structures by cycles of alternative plasma etching of the polymer and wet etching of Au, in which the lateral geometry was defined by poly(methyl methacrylate) (PMMA) brushes and height of each step was controlled by the etching conditions.…”
Section: Methodsmentioning
confidence: 99%
“…[12] The principle of morphology control is that polymer brushes of similar chain length, grown from areas of low-grafting density of initiators, form collapsed structures, whereas chains grown from areas of high-grafting density form strechted structures because of the competition between interface energy and chain entropy. As proof-ofconcept, arbitrary 3D functional polymer brushes were obtained at nanoscale when nanolithographic tools such as electron-beam (e-beam) lithography [13][14][15][16][17][18] and dip-pen nanodisplacement lithography (DNL) [19] were used to locally program the grafting density of surface initiators. Nevertheless, precise control and characterization of the grafting density of initiators are still daunting tasks.…”
mentioning
confidence: 99%
“…[1,4,7] Im Fall der EBL gelingt die Herstellung eines chemischen Templats für die Proteinadsorption durch Transformation spezifischer Schwanzgruppen aromatischer SAMs [9,10] oder durch strahlungsinduzierte Austauschreaktion (IPER), wobei Moleküle in einer aliphatischen SAM durch andere Moleküle substituiert werden. [11] Der erstgenannte Ansatz erfordert allerdings einen zusätzli-chen Arbeitsschritt, nämlich das Auffüllen nichtbestrahlter Bereiche durch OEG-basierte Moleküle, der langsam verläuft. [9] Die Einsatzmöglichkeiten der IPER sind aufgrund der geringen Effizienz im Fall von langkettigen OEG-basierten SAMs [12] ebenfalls eingeschränkt.…”
unclassified
“…Daher wurden bisher nur inverse Proteinmuster (proteinabweisende Muster auf proteinadsorbierendem Untergrund) durch IPER hergestellt. [11] In Anbetracht dieser Probleme könnte man erwägen, aliphatische SAMs, ähnlich den aromatischen Filmen, direkt zu strukturieren. Im Unterschied zu letzterem System kann die Schwanzgruppe aliphatischer SAMs allerdings normalerweise nicht spezifisch durch Elektronenbestrahlung modifiziert werden, ohne erheblichen Schaden innerhalb des Films zu verursachen und die Qualität des Templats zu verschlechtern.…”
unclassified
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