Microneedles: An Effective Technique for Transdermal Drug Delivery

Chitra, K.; Bhimavarapu, Ramadevi; Rani.B, Samyuktha; Priyadarshini, Indira; Reddy, Ambati Brahma

doi:10.7439/ijbr.v2i8.127

Cited by 2 publications

(5 citation statements)

References 10 publications

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“…1). Similar changes in colour have also been observed in previous studies [32,33], thereby confirming the completion of reaction between the stem extracts and AgNO3. The AgNPs formation by reducing silver ions was investigated by UV-visible spectroscopy.…”

Section: Resultssupporting

confidence: 90%

“…4a) showed that the particles are agglomerated and there was no clear shape. Similar result has been reported by Chitra and Annadurai [32]. The agglomeration might be due to the existence of large interaction between nanoparticles [41].…”

Section: Resultssupporting

confidence: 89%

“…The data analysis showed sizes of silver nanoparticles in the range of 3-41 nm and 3-27 nm spherical shaped for SL-AgNPs and MA-AgNPs, respectively which may confer the ability to penetrate the cells/microbes and execute their bactericidal properties. Similar size ranges of AgNPs have been reported [32,33,44].…”

Section: Resultssupporting

confidence: 86%

“…4c and 4d). In general, metallic silver nanocrystals show typical optical absorption peak approximately at 3 keV due to their surface plasmon resonance [32,42,43]. The elemental analysis of the silver nanoparticles shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

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Characterization and Biological Activities of Silver Nanoparticles Synthesized from Stems of Sarcocephalus latifolius (Sm) E.A. Bruce and Massularia acuminata (G. Don) Bullock ex Hoyl. (Rubiaceae)

Ajayi¹,

Odeyemi²,

Otunola³

et al. 2017

Asian J. Chem.

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Silver nanoparticles (AgNPs) have been synthesized from the stems of Sarcocephalus latifolius (SL) and Massularia acuminata (MA) and characterized for their sizes and shapes using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Complete formations of the AgNPs were observed with colour change from colourless to brownish-black. Fourier transform infrared spectroscopy (FT-IR) and energy dispersive X-ray spectroscopy (EDS/EDX) were conducted to detrmine the various functional groups and the concentration of metal ions of the molecules. The data analysis showed sizes of 3-41 nm and 3-37 nm, spherical shaped nanoparticles for Sarcocephalus latifolius and Massularia acuminata, respectively as revealed by TEM, complementing the results for SEM. FT-IR identifies ethylene groups as the reducing and capping agents for the formation of the nanoparticles. The X-ray diffraction pattern confirmed the presence of silver crystallites and as well as their sizes, confirming the TEM results. Silver nanoparticles exhibited not too good potentials as free radical scavengers when compared to the standard drugs. The synthesized AgNPs in suspension showed activity against Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs) to be in the range from 62.5 to 250 µg/mL. In summary, the synthesized AgNPs showed acceptable sizes and shapes of nanoparticles.

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Section: Resultssupporting

confidence: 90%

Section: Resultssupporting

confidence: 89%

Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Characterization and Biological Activities of Silver Nanoparticles Synthesized from Stems of Sarcocephalus latifolius (Sm) E.A. Bruce and Massularia acuminata (G. Don) Bullock ex Hoyl. (Rubiaceae)

Ajayi¹,

Odeyemi²,

Otunola³

et al. 2017

Asian J. Chem.

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“…The application of nanoscale materials and structures, usually ranging from 1 to 100 nm is an emerging area of nanoscience and nanotechnology. Nanoscale materials are finding applications in biosensing, media recording, optics, catalysis, and environmental analysis and remediation [1].…”

Section: Introductionmentioning

confidence: 99%

Electrokinetic Behavior of Multiwalled Carbon Nanotubes/Poly-l -lysine Modified Electrodes in Sodium Dodecylsulfate Bicontinuous Microemulsions

Guto

2017

Int. J. Chem. Kinet.

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This work demonstrates for the first time the application of multiwalled carbon nanotubes/poly‐l‐lysine modified pyrolytic graphite electrodes (MWCNTs/PLL/PGE) in sodium dodecylsulfate bicontinuous (SDS BC) microemulsions. Cyclic voltammetric studies of ruthenium(III)hexaamine electroactive probe in these media on both plain and modified pyrolytic graphite electrodes (PGE) mainly gave one peak for each of the cathodic and anodic scans. These reduction–oxidation responses were attributed to [Ru(NH3)6]2+/[Ru(NH3)6]3+ redox couple. In SDS BC microemulsions, the midpoint potentials were found to be −0.22 V for PGE plain and −0.24 V for MWCNTs/PLL/PGE versus saturated calomel electrode. The average peak separations for PGE plain and MWCNTs/PLL/PGE were found to be ∼0.05 and ∼0.04 V between the scan rates of 0.01 and 0.1 V/s, whereas their diffusion coefficients were 1.0 × 10−6 and 7.0 × 10−6 cm2/s, respectively. The rates of electron transfer constants were also found to be 1.47 × 10−1 cm/s for PGE plain and 7.38 × 10−1 cm/s for MWCNTs/PLL/PGE. These enhanced responses were attributed to possible increased surface area of the modified electrode, good distribution of nanotubes within the poly‐l‐lysine matrix, and increased porosity within the MWCNTs/PLL/PGE composite making the nanotubes fully accessible to the electroactive probe. Overly these observations in microemulsions are similar to those observed in phosphate buffer solutions, pH 6.5. Moreover, this study shows a possible application of microemulsions in electroanalysis where simultaneous analysis of both organic and inorganic pollutants in environmental samples is required.

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Microneedles: An Effective Technique for Transdermal Drug Delivery

Cited by 2 publications

References 10 publications

Characterization and Biological Activities of Silver Nanoparticles Synthesized from Stems of Sarcocephalus latifolius (Sm) E.A. Bruce and Massularia acuminata (G. Don) Bullock ex Hoyl. (Rubiaceae)

Characterization and Biological Activities of Silver Nanoparticles Synthesized from Stems of Sarcocephalus latifolius (Sm) E.A. Bruce and Massularia acuminata (G. Don) Bullock ex Hoyl. (Rubiaceae)

Electrokinetic Behavior of Multiwalled Carbon Nanotubes/Poly-l -lysine Modified Electrodes in Sodium Dodecylsulfate Bicontinuous Microemulsions

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