Microparticle formation in apheresis platelets is not affected by three leukoreduction filters

Abstract

Although the conditions of this study showed no favorable or unfavorable effects of three different filters on microparticle formation, surveillance and investigation of unanticipated outcomes in other experimental and clinical circumstances should continue.

The pro‐inflammatory potential of microparticles in red blood cell units

“…There remains debate as to whether LR leads to a decrease in MPs. Similar to the presented data, LR of apheresis Plt concentrates did not affect MP formation (Nollet et al , ). In contrast, the same research group demonstrated that whole blood LR did decrease MP formation (Sugawara et al , ).…”

The effects of apheresis, storage time, and leukofiltration on microparticle formation in apheresis platelet products

“…WBC filtration of whole blood was reported to lower PMP and LMP counts during storage . However, a previous study reported that WBC filtration of apheresis PLT products had virtually no effects on the formation of PMPs, RMPs, and LMPs . Our work further suggested that WBC filtration exerted no effects on the formation of MMPs and EMPs.…”

“…Multiple studies have reported that PMPs are generated during storage of apheresis PLTs ex vivo . MPs originating from red blood cells (RBCs), lymphocytes, monocytes, and endotheliocytes in circulating blood may enter PLT supernatants . As a measurable amount of their parental cells are contained in the apheresis PLT products, these MPs may be generated during the time of storage.…”

The hemostatic activity of cryopreserved platelets is mediated by phosphatidylserine‐expressing platelets and platelet microparticles

“…Despite the high amount of PLT microparticles generated in response to cryopreservation, the numbers decreased during storage at room temperature for 24 hours. This result was counterintuitive, as microparticle numbers have been shown to increase during extended storage (14 days) of apheresis PLTs . An explanation for this result may be due to the way that the microparticles have been defined in this study, by dual expression of CD61 and phosphatidylserine.…”