Microparticle miRNAs as Biomarkers of Vascular Function and Inflammation Response to Aerobic Exercise in Obesity?

Dimassi, Saloua; Karkeni, Esma; Laurant, Pascal; Tabka, Zouhaïr; Landrier, Jean‐François; Riva, Catherine

doi:10.1002/oby.22298

Cited by 30 publications

(28 citation statements)

References 45 publications

(56 reference statements)

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“…In exercise, the expression of various members of this family was reported to increase after a marathon or systematic training with walking/running in middle-aged men and women [ 118 , 129 ] or decrease in acute and systematic cycling training in middle-aged participants [ 123 , 128 ]. miR-21 may have both pro- and anti-inflammatory properties, and its expression is reported to be rising in participants of marathons and some studies with acute cycling and sustained rowing exercise and high-intensity intervals or endurance training [ 117 , 124 , 125 , 127 , 130 , 133 ]. On the other hand, there was a study on acute cycling by athletes (basketball players) where the miR-21 expression was decreased [ 126 ].…”

Section: Epigenetic Changes Involved In Immune Responsesmentioning

confidence: 99%

Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity

Tarnowski

Kopytko

Piotrowska

2021

Genes

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Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vital trigger of epigenetic changes that in turn modulate inflammatory actions. The tissue responses to PA involve local and general changes. The epigenetic mechanisms involved include: DNA methylation, histone proteins modification and microRNA. All of them affect genetic expression in an inflammatory milieu in physical exercise depending on the magnitude of physiological stress experienced by the exerciser. PA may evoke acute or chronic biochemical and physiological responses and have a positive or negative immunomodulatory effect.

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Section: Epigenetic Changes Involved In Immune Responsesmentioning

confidence: 99%

Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity

Tarnowski

Kopytko

Piotrowska

2021

Genes

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“…A great number of studies have shown that miRNAs are differently enriched in MVs, and their expression patterns also change with respect to different diseases . Therefore, MVs and associated miRNAs are considered to be potential diagnostic biomarkers of diseases . For instance, in a prospective study, in 176 patients with stable coronary artery disease (CAD), Jansen F at al.…”

Section: Existing Problems Of Mvs and The Clinical Prospectsmentioning

confidence: 99%

“…130 Therefore, MVs and associated miRNAs are considered to be potential diagnostic biomarkers of diseases. [131][132][133] For instance, in a prospective study, in 176 patients with stable coronary artery disease (CAD), Jansen F at al. found that the level of miR-126 or miR-199a expression in circulating MVs but not in plasma could predict the occurrence of cardiovascular events in stable CAD patients.…”

Section: The Clinical Prospect Of Mvsmentioning

confidence: 99%

The role of microvesicles containing microRNAs in vascular endothelial dysfunction

Shu

Tan

Miao

et al. 2019

J Cellular Molecular Medi

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Many studies have shown that endothelial dysfunction is associated with a variety of cardiovascular diseases. The endothelium is one of the primary targets of circulating microvesicles. Besides, microRNAs emerge as important regulators of endothelial cell function. As a delivery system of microRNAs, microvesicles play an active and important role in regulating vascular endothelial function. In recent years, some studies have shown that microvesicles containing microRNAs regulate the pathophysiological changes in vascular endothelium, such as cell apoptosis, proliferation, migration and inflammation. These studies have provided some clues for the possible roles of microvesicles and microRNAs in vascular endothelial dysfunction‐associated diseases, and opened the door towards discovering potential novel therapeutic targets. In this review, we provide an overview of the main characteristics of microvesicles and microRNAs, summarizing their potential role and mechanism in endothelial dysfunction, and discussing the clinical application and existing problems of microvesicles for better translational applications.

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“…miR-129-5p isolated from plasma MVs was demonstrated to be a sensitive and specific biomarker for heart failure (HF) in univentricular heart disease [ 17 ]. In addition, MP miR-124a and miR-150, which were found to be more abundant in obese subjects compared to normal weight controls, were found to be significantly associated with inflammation and vascular function in obesity [ 18 ]. As a consequence, lEV-miRNAs are emerging as attractive biomarkers due to their stability and easy detection in biofluids.…”

Section: Introductionmentioning

confidence: 99%

Increased expression of six-large extracellular vesicle-derived miRNAs signature for nonvalvular atrial fibrillation

et al. 2022

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Backgrounds Non-valvular atrial fibrillation (AF) is the most common type of cardiac arrhythmia. AF is caused by electrophysiological abnormalities and alteration of atrial tissues, which leads to the generation of abnormal electrical impulses. Extracellular vesicles (EVs) are membrane-bound vesicles released by all cell types. Large EVs (lEVs) are secreted by the outward budding of the plasma membrane during cell activation or cell stress. lEVs are thought to act as vehicles for miRNAs to modulate cardiovascular function, and to be involved in the pathophysiology of cardiovascular diseases (CVDs), including AF. This study identified lEV-miRNAs that were differentially expressed between AF patients and non-AF controls. Methods lEVs were isolated by differential centrifugation and characterized by Nanoparticle Tracking Analysis (NTA), Transmission Electron Microscopy (TEM), flow cytometry and Western blot analysis. For the discovery phase, 12 AF patients and 12 non-AF controls were enrolled to determine lEV-miRNA profile using quantitative reverse transcription polymerase chain reaction array. The candidate miRNAs were confirmed their expression in a validation cohort using droplet digital PCR (30 AF, 30 controls). Bioinformatics analysis was used to predict their target genes and functional pathways. Results TEM, NTA and flow cytometry demonstrated that lEVs presented as cup shape vesicles with a size ranging from 100 to 1000 nm. AF patients had significantly higher levels of lEVs at the size of 101–200 nm than non-AF controls. Western blot analysis was used to confirm EV markers and showed the high level of cardiomyocyte expression (Caveolin-3) in lEVs from AF patients. Nineteen miRNAs were significantly higher (> twofold, p < 0.05) in AF patients compared to non-AF controls. Six highly expressed miRNAs (miR-106b-3p, miR-590-5p, miR-339-3p, miR-378-3p, miR-328-3p, and miR-532-3p) were selected to confirm their expression. Logistic regression analysis showed that increases in the levels of these 6 highly expressed miRNAs associated with AF. The possible functional roles of these lEV-miRNAs may involve in arrhythmogenesis, cell apoptosis, cell proliferation, oxygen hemostasis, and structural remodeling in AF. Conclusion Increased expression of six lEV-miRNAs reflects the pathophysiology of AF that may provide fundamental knowledge to develop the novel biomarkers for diagnosis or monitoring the patients with the high risk of AF.

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Microparticle miRNAs as Biomarkers of Vascular Function and Inflammation Response to Aerobic Exercise in Obesity?

Cited by 30 publications

References 45 publications

Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity

Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity

The role of microvesicles containing microRNAs in vascular endothelial dysfunction

Increased expression of six-large extracellular vesicle-derived miRNAs signature for nonvalvular atrial fibrillation

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