MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates

Zhang, X.; Talpos, John C.; Berridge, Marc S.; Apana, Scott M.; Slikker, William; Wang, C.; Paule, Merle G.

doi:10.1016/j.ntt.2021.107017

Cited by 6 publications

(2 citation statements)

References 97 publications

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“…[45][46][47][48] Among the animal models used to determine the neurotoxic potential of GAs and other drugs or substances, eg, methylphenidate, nicotine, cocaine, marijuana, etc, NHP models are considered more predictive because of similarities with humans in genetics, reproduction, development, neuroanatomical organization, and cognitive capacities. [49][50][51][52][53][54] For the GA studies, the specific advantages of the NHP models include easy management of the anesthesia procedure, monitoring physical wellbeing during exposure, and availability (repeated) of blood and/or CSF sample collection. No other commonly used animal model has a functional fetal placental unit, a propensity for single birth, and a fetal-to-maternal weight ratio comparable to that of humans.…”

Section: Anesthesia and Analgesiamentioning

confidence: 99%

Application of Nonhuman Primate Models in the Studies of Pediatric Anesthesia Neurotoxicity

Wang

Liu

et al. 2022

Anesthesia &Amp; Analgesia

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Numerous animal models have been used to study developmental neurotoxicity associated with short-term or prolonged exposure of common general anesthetics at clinically relevant concentrations. Pediatric anesthesia models using the nonhuman primate (NHP) may more accurately reflect the human condition because of their phylogenetic similarity to humans with regard to reproduction, development, neuroanatomy, and cognition. Although they are not as widely used as other animal models, the contribution of NHP models in the study of anesthetic-induced developmental neurotoxicity has been essential. In this review, we discuss how neonatal NHP animals have been used for modeling pediatric anesthetic exposure; how NHPs have addressed key data gaps and application of the NHP model for the studies of general anesthetic-induced developmental neurotoxicity. The appropriate application and evaluation of the NHP model in the study of general anesthetic-induced developmental neurotoxicity have played a key role in enhancing the understanding and awareness of the potential neurotoxicity associated with pediatric general anesthetics.

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Section: Anesthesia and Analgesiamentioning

confidence: 99%

Application of Nonhuman Primate Models in the Studies of Pediatric Anesthesia Neurotoxicity

Wang

Liu

et al. 2022

Anesthesia &Amp; Analgesia

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“…1). Studies using the nonhuman primate model have focused on the effects of developmental exposure to childhood medications, such as methylphenidate (Liachenko et al., 2022; Zhang et al., 2021), but most are aimed at elucidating the teratogenic or neurotoxic properties of environmental chemicals or drugs of misuse. Depending on the timing of exposure, neurotoxicology studies may focus on the presence of major and minor congenital anomalies, adverse neonatal outcomes, neurodevelopmental deficits, and brain pathology.…”

Section: Contributions Of Nonhuman Primates To the Field Of Neurotoxi...mentioning

confidence: 99%

The Role of Nonhuman Primates in Neurotoxicology Research: Preclinical Models and Experimental Methods

2023

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Although noteworthy progress has been made in developing alternatives to animal testing, nonhuman primates still play a critical role in advancing biomedical research and will likely do so for many years. Core similarities between monkeys and humans in genetics, physiology, reproduction, development, and behavior make them excellent models for translational studies relevant to human health. This unit is designed to specifically address the role of nonhuman primates in neurotoxicology research and outlines the specialized assessments that can be used to measure exposure-related changes at the structural, chemical, cellular, molecular, and functional levels.

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In pursuit of precision medicine for brain injury and neurotoxicity and improved protection of human health

Slikker¹,

Wu²,

Xu³

et al. 2024

Comprehensive Precision Medicine

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MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates

Cited by 6 publications

References 97 publications

Application of Nonhuman Primate Models in the Studies of Pediatric Anesthesia Neurotoxicity

Application of Nonhuman Primate Models in the Studies of Pediatric Anesthesia Neurotoxicity

The Role of Nonhuman Primates in Neurotoxicology Research: Preclinical Models and Experimental Methods

In pursuit of precision medicine for brain injury and neurotoxicity and improved protection of human health

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