Microporous Coordination Polymers As Selective Sorbents for Liquid Chromatography

Abstract

We evaluate the potential of microporous coordination polymers (MCPs) to act as the stationary phase in liquid chromatographic separations. MCPs derived from carboxylates coordinated to copper (HKUST-1) and zinc (MOF-5) were studied. The shape and size selective separation of organic compounds including benzene, ethylbenzene, styrene, naphthalene, anthracene, phenanthrene, pyrene, 1,3,5-triphenylbenzene, and 1,3,5-tris(4-bromophenyl)benzene was performed, and in most cases excellent separation was achieved based on a combination of molecular sieving and adsorption effects.

Metal–Organic Framework MIL-101(Cr) for High-Performance Liquid Chromatographic Separation of Substituted Aromatics

“…The same elution sequence of EB and styrene was also observed on HKUST-1 with Cu unsaturated metal sites. 30,37 Furthermore, a mixture of EB and styrene with their typical impurities of toluene and o-xylene were also well separated on the MIL-101(Cr) packed column ( Figure 1D) with good precision (0.2À0.4%, 0.9À1.5%, 0.6À1.7%, and 0.6À1.7% (RSD, n = 5) for the retention time, peak area, peak height, and half peak width, respectively) ( Table 1).…”

“…25À29 Size and shape selectivity of MOF-5 and HKUST-1 for the liquid chromatographic separation of organic compounds has also been reported. 30 SilicaÀCu 3 (BTC) 2 composites as the stationary phase for HPLC separation of EB and styrene have also been investigated. 31 Many MOFs are available now with sufficiently large pore windows and cages and the aromatic rings which make them attractive candidates for the separation of substituted aromatics.…”

Metal‐Organic Frameworks: Application to Analytical Chemistry

“…Ahmad et al 62 reported the separation of benzene, naphthalene, anthracene, phenanthrene, pyrene, 1,3,5-triphenylbenzene, and 1,3,5-tris(4-bromophenyl)benzene on MOF-199-and MOF-5-packed columns based on the combination of molecular sieving and adsorption effects. Separation of ethylbenzene and styrene with very similar dimensions was also achieved on MOF-199 column.…”

Insights into the separation performance of MOFs by high-performance liquid chromatography and in-depth modelling

“…Several studies have investigated the performance of columns filled with bulk MOFs for liquid chromatography [9][10][11][12]. However, the results are mostly limited to validating a proof-of-concept for the separation of analyte mixtures and to demonstrating the influence of different parameters onto the observed retention times.…”