microRNA-155 regulates angiotensin II type 1 receptor expression in umbilical vein endothelial cells from severely pre-eclamptic pregnant women

Cheng, Weiwei; Liu, Te; Jiang, Feizhou; Liu, Chunmin; Zhao, Xin; Gao, Yongtao; Wang, Hui; Liu, Zhixue

doi:10.3892/ijmm.2011.598

Cited by 37 publications

(24 citation statements)

References 21 publications

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“…Later, Zhang et al (2010) found a similar trend in miR-155 greatly upregulated in preeclampsia placenta. By contrast, Cheng et al (2011) demonstrated that severely preeclamptic pregnant women had less mature miR-155, yet a much higher expression of AT1R in their human umbilical vein endothelia cells (HUVECs) compared with healthy puerperant women. Similarly, a recent study indicated that overexpression of miR-155 in HUVECs (Zhu et al 2011) suppressed the expression of AT1R via interacting (Xu et al 2008).…”

Section: Mirna Related To Raas In Preeclampsiamentioning

confidence: 95%

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Yang¹,

Shang²,

Zhang³

et al. 2013

Journal of Molecular Endocrinology

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The compensatory alterations in the rennin-angiotensin-aldosterone system (RAAS) contribute to the salt-water balance and sufficient placental perfusion for the subsequent well-being of the mother and fetus during normal pregnancy and is characterized by an increase in almost all the components of RAAS. Preeclampsia, however, breaks homeostasis and leads to a disturbance of this delicate equilibrium in RAAS both for circulation and the uteroplacental unit. Despite being a major cause for maternal and neonatal morbidity and mortality, the pathogenesis of preeclampsia remains elusive, where RAAS has been long considered to be involved. Epidemiological studies have indicated that preeclampsia is a multifactorial disease with a strong familial predisposition regardless of variations in ethnic, socioeconomic, and geographic features. The heritable allelic variations, especially the genetic polymorphisms in RAAS, could be the foundation for the genetics of preeclampsia and hence are related to the development of preeclampsia. Furthermore, at a posttranscriptional level, miRNA can interact with the targeted site within the 3 0 -UTR of the RAAS gene and thereby might participate in the regulation of RAAS and the pathology of preeclampsia. In this review, we discuss the recent achievements of genetic polymorphisms, as well as the interactions between maternal and fetal genotypes, and miRNA posttranscriptional regulation associated with RAAS in preeclampsia. The results are controversial but utterly inspiring and attractive in terms of potential prognostic significance. Although many studies suggest positive associations with genetic mutations and increased risk for preeclampsia, more meticulously designed large-scale investigations are needed to avoid the interference from different variations.

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Section: Mirna Related To Raas In Preeclampsiamentioning

confidence: 95%

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Yang¹,

Shang²,

Zhang³

et al. 2013

Journal of Molecular Endocrinology

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“…Cheng and colleagues found that miR-155 was downregulated in the preeclamptic patient endothelial cells. Further study identified another critical preeclamptic pathogenic factor, angiotensin II type 1 receptor, as a target of miR-155 [58]. In addition, miR-155 was linked to the trophoblast function, including proliferation, invasion, and differentiation [59, 60].…”

Section: Placental Micrornamentioning

confidence: 99%

Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications

Cai

Kolluru

Ahmed

2017

Journal of Pregnancy

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MicroRNAs are small, noncoding RNA molecules that regulate target gene expression in the posttranscriptional level. Unlike siRNA, microRNAs are “fine-tuners” rather than “switches” in the regulation of gene expression; thus they play key roles in maintaining tissue homeostasis. The aberrant microRNA expression is implicated in the disease process. To date, numerous studies have demonstrated the regulatory roles of microRNAs in various pathophysiological conditions. In contrast, the study of microRNA in pregnancy and its associated complications, such as preeclampsia (PE), fetal growth restriction (FGR), and preterm labor, is a young field. Over the last decade, the knowledge of pregnancy-related microRNAs has increased and the molecular mechanisms by which microRNAs regulate pregnancy or its associated complications are emerging. In this review, we focus on the recent advances in the research of pregnancy-related microRNAs, especially their function in pregnancy-associated complications and the potential clinical applications. Here microRNAs that associate with pregnancy are classified as placenta-specific, placenta-associated, placenta-derived circulating, and uterine microRNA according to their localization and origin. MicroRNAs offer a great potential for developing diagnostic and therapeutic targets in pregnancy-related disorders.

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“…Several of the candidates we identified (miR-155-5p, -21-3p, and -223-3p) are highly expressed in a variety of tissues and have been associated with a number of malignant and non-malignant disease states[59], suggesting they might play roles in regulatory pathways common across cell types, including apoptosis, cell-cycle regulation, and response to inflammation. For example, upregulation of miR-155 in both umbilical vein endothelial cells and placenta tissues has been implicated in the pathogenesis of pre-eclampsia, possibly by inhibiting trophoblast invasion and proliferation via the cell-cycle regulator Cyclin D1[60, 61]. miR-155 and -146b, also identified in our study, are induced by inflammatory cytokines, including NF-κB[46, 62, 63].…”

Section: Discussionmentioning

confidence: 76%

Circulating early- and mid-pregnancy microRNAs and risk of gestational diabetes

Wander

Boyko

Hevner

et al. 2017

Diabetes Research and Clinical Practice

116

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Aims Epigenetic regulators, including microRNAs(miRNAs), are implicated in type 2 diabetes, but evidence linking circulating miRNAs in pregnancy and risk of gestational diabetes(GDM) is sparse. Potential modifiers, including pre-pregnancy overweight/obesity and offspring sex, are unexamined. We hypothesized that circulating levels of early-mid-pregnancy(range 7-23 weeks of gestation) candidate miRNAs are related to subsequent development of GDM. We also hypothesized that miRNA-GDM associations might vary by pre-pregnancy body-mass index(ppBMI) or offspring sex. Methods In a case-control analysis(36 GDM cases/80 controls) from the Omega study, a prospective cohort study of pregnancy complications, we measured early–mid-pregnancy plasma levels of 10 miRNAs chosen for potential roles in pregnancy course and complications(miR-126-3p, -155-5p, -21-3p, -146b-5p, -210-3p, -222-3p, -223-3p, -517-5p, -518a-3p, and 29a-3p) using qRT-PCR. Logistic regression models adjusted for gestational age at blood draw (GA) were fit to compare circulating miRNAs between cases and controls. We repeated analyses among overweight/obese(ppBMI≥25kg/m2) or lean(ppBMI<25kg/m2) women, and women with male or female offspring separately. Results Mean age was 34.3 years(cases) and 32.9 years(controls). GA-adjusted miR-155-5p(β=0.260/p=0.028) and - 21-3p(β=0.316/p=0.005) levels were positively associated with GDM. MiR-146b-5p(β=0.266/p=0.068) and miR-517-5p(β=0.196/p=0.074) were borderline. Associations of miR-21-3p and miR-210-3p with GDM were observed among overweight/obese but not lean women. Associations of six miRNAs(miR-155-5p, -21-3p, - 146b-5p, -223-3p, -517-5p, and -29a-3p) with GDM were present only among women carrying male fetuses(all p<0.05). Conclusions Circulating early–mid-pregnancy miRNAs are associated with GDM, particularly among women who are overweight/obese pre-pregnancy or pregnant with male offspring. This area has potential to clarify mechanisms underlying GDM pathogenesis and identify at-risk mothers earlier in pregnancy.

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microRNA-155 regulates angiotensin II type 1 receptor expression in umbilical vein endothelial cells from severely pre-eclamptic pregnant women

Cited by 37 publications

References 21 publications

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications

Circulating early- and mid-pregnancy microRNAs and risk of gestational diabetes

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