MicroRNA-181a and its target Smad 7 as potential biomarkers for tracking child acute lymphoblastic leukemia

Nabhan, Marwa M.; Louka, Manal L.; Khairy, Eman; Tash, Fathy; Ali-Labib, Randa; Elhabashy, Safinaz Adel

doi:10.1016/j.gene.2017.07.052

Cited by 32 publications

(33 citation statements)

References 45 publications

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“…Nabhan et al[ 47 ] focused on analyzing the involvement of just one marker molecule in the development of leukemia, i.e . miR-181a can both function as a tumor suppressor or an oncogene.…”

Section: Role Of Microrna In Diagnosis and Classificationmentioning

confidence: 99%

Role of microRNA dysregulation in childhood acute leukemias: diagnostics, monitoring and therapeutics: A comprehensive review

Szczepanek

2020

WJCO

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MicroRNAs (miRNAs) are short noncoding RNAs that regulate the expression of genes by sequence-specific binding to mRNA to either promote or block its translation; they can also act as tumor suppressors ( e.g ., let-7b, miR-29a, miR-99, mir-100, miR-155, and miR-181) and/or oncogenes ( e.g ., miR-29a, miR-125b, miR-143-p3, mir-155, miR-181, miR-183, miR-196b, and miR-223) in childhood acute leukemia (AL). Differentially expressed miRNAs are important factors associated with the initiation and progression of AL. As shown in many studies, they can be used as noninvasive diagnostic and prognostic biomarkers, which are useful in monitoring early stages of AL development or during therapy ( e.g ., miR-125b, miR-146b, miR-181c, and miR-4786), accurate classification of different cellular or molecular AL subgroups ( e.g ., let-7b, miR-98, miR-100, miR-128b, and miR-223), and identification and development of new therapeutic agents ( e.g ., mir-10, miR-125b, miR-203, miR-210, miR-335). Specific miRNA patterns have also been described for commonly used AL therapy drugs ( e.g ., miR-125b and miR-223 for doxorubicin, miR-335 and miR-1208 for prednisolone, and miR-203 for imatinib), uncovering miRNAs that are associated with treatment response. In the current review, the role of miRNAs in the development, progression, and therapy monitoring of pediatric ALs will be presented and discussed.

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“…Nabhan et al[ 47 ] focused on analyzing the involvement of just one marker molecule in the development of leukemia, i.e . miR-181a can both function as a tumor suppressor or an oncogene.…”

Section: Role Of Microrna In Diagnosis and Classificationmentioning

confidence: 99%

Role of microRNA dysregulation in childhood acute leukemias: diagnostics, monitoring and therapeutics: A comprehensive review

Szczepanek

2020

WJCO

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“…numerous diseases, such as cervical cancer (39), child acute lymphoblastic leukemia (40) and gastric cancer (41). Some studies have shown that miR-181a serves as a novel marker for the inflammatory response (42,43).…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding maternally expressed gene 3 regulates cigarette smoke extract‑induced apoptosis, inﬂammation and cytotoxicity by sponging miR‑181a‑2‑3p in 16HBE cells

Fan¹,

Ren²,

Zhang³

et al. 2020

Oncol Lett

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Accumulating evidence has suggested that long non-coding (lnc)RNAs are widely involved in the progression of multiple diseases, including chronic obstructive pulmonary disease (COPD). The aim of the present study was to explore the function and molecule mechanism of maternally expressed gene 3 (MEG3) in cigarette smoke extract (CSE)-treated 16HBE cells. Cell viability and apoptosis were evaluated using Cell Counting Kit-8 analysis and flow cytometry, respectively. Western blot analysis was carried out to determine the protein levels of Bcl-2, Bax and cleaved caspase-3. ELISA assays were utilized to measure the protein levels of IL-1β and IL-6 and TNF-α. Cytotoxicity was assessed using a lactate dehydrogenase release assay. The expression levels of MEG3 and microRNA (miR)-181a-2-3p were detected using reverse transcription-quantitative PCR. The interaction between miR-181a-2-3p and MEG3 was predicted using DIANA tools and verified by a dual-luciferase reporter assay and RNA Immunoprecipitation assay. MEG3 expression was enhanced while miR-181a-2-3p abundance was reduced in the serum of patients with COPD and CSE-treated 16HBE cells. MEG3-knockdown or miR-181a-2-3p-overexpression inhibited CSE-induced apoptosis, inflammation and cytotoxicity in 16HBE cells. Moreover, miR-181a-2-3p directly bind to MEG3 and its knockdown reversed the inhibitory effect of MEG3 interference on apoptosis, inflammation and cytotoxicity in CSE-treated 16HBE cells. Overall, MEG3-knockdown suppressed CSE-induced apoptosis, inflammation and cytotoxicity in 16HBE cells by upregulating miR-181a-2-3p, providing a promising therapeutic target for treatment of CSE-induced COPD.

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“…The main function of this cluster is to suppress B-cell maturation and provide an equilibrium between B and myeloid cells [52]. However, the role of miR-181a goes far beyond B-cell regulation, and it is deeply involved in such processes as gastric cancer, and lymphoblastic leukemia or may serve as a biomarker in multiple myeloma [53][54][55].…”

Section: B-cellsmentioning

confidence: 99%

MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS)

Kotyla

Islam

2020

IJMS

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MicroRNAs (miRNAs) are single-stranded, endogenous RNA molecules that play a significant role in the regulation of gene expression as well as cell development, differentiation, and function. Recent data suggest that these small molecules are responsible for the regulation of immune responses. Therefore, they may act as potent modulators of the immune system and play an important role in the development of several autoimmune diseases. Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by venous and/or arterial thromboses and/or recurrent fetal losses in the presence of antiphospholipid antibodies (aPLs). Several lines of evidence suggest that like other autoimmune disorders, miRNAs are deeply involved in the pathogenesis of APS, interacting with the function of innate and adaptive immune responses. In this review, we characterize miRNAs in the light of having a functional role in the immune system and autoimmune responses focusing on APS. In addition, we also discuss miRNAs as potential biomarkers and target molecules in treating APS.

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MicroRNA-181a and its target Smad 7 as potential biomarkers for tracking child acute lymphoblastic leukemia

Cited by 32 publications

References 45 publications

Role of microRNA dysregulation in childhood acute leukemias: diagnostics, monitoring and therapeutics: A comprehensive review

Role of microRNA dysregulation in childhood acute leukemias: diagnostics, monitoring and therapeutics: A comprehensive review

Long non‑coding maternally expressed gene 3 regulates cigarette smoke extract‑induced apoptosis, inﬂammation and cytotoxicity by sponging miR‑181a‑2‑3p in 16HBE cells

MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS)

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