MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells

Wang, Changzheng; Qiao, Chuan-hu

doi:10.1007/s10529-016-2273-2

Cited by 17 publications

(25 citation statements)

References 15 publications

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“…25 Wang et al demonstrated that miR-190b enhanced the radio-sensitivity of GC cells through negatively regulated Bcl-2. 26 Ding et al revealed that miR-27a stimulated the tumorgenesis of GC by activating the AKT/GSK3b pathway. 27 Mi et al validated that miR-181a-5p facilitated the development of GC via RASSF6-modulated MAPK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4

Gao

Wang

et al. 2018

Cancer Biology & Therapy

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Section: Discussionmentioning

confidence: 99%

MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4

Gao

Wang

et al. 2018

Cancer Biology & Therapy

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“…40 Current therapeutic strategies were considered to optimize radiosensitivity of GC to F I G U R E 4 Elevated expression of lincRNA-p21 suppressed the GC cell cycle and migration. [42][43][44] The molecular mechanism of radiosensitivity in the GC is still unknown. B, Ectopic expression of lincRNA-p21 suppressed the SGC7901 cell cycle.…”

Section: Discussionmentioning

confidence: 99%

LincRNA‐p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β‐catenin signaling pathway

Chen

Yuan

Yang

et al. 2018

J of Cellular Biochemistry

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Long noncoding RNAs (lncRNAs) are a large and diverse class of transcribed RNA molecules with a length of more than 200 nucleotides that modulate the gene expression at the posttranscriptional or transcriptional level. LncRNAs played crucial roles in many biological processes, such as cell proliferation, metastasis, and migraton. In this study, we evaluated the role of lincRNA‐p21 in the gastric cancer (GC). We demonstrated that the expression level of lincRNA‐p21 was downregulated in the GC tissues and cell lines. Moreover, ectopic expression of lincRNA‐p21 suppressed the GC cell growth, cell cycle, and migration. Furthermore, we demonstrated that the X‐ray increased the expression level of lincRNA‐p21 in both the HCG‐27 and SGC7901 cells and elevated expression of lincRNA‐p21 increased the radiotherapy sensitivity of the GC cell. In addition, we showed that ectopic expression of lincRNA‐p21 suppressed the β‐catenin and c‐myc expression. Overexpression of lincRNA‐p21 inhibited the GC cell proliferation and increased the radiosensitivity of GC cells by regulating the β‐catenin signaling pathway. These data suggested that lincRNA‐p21 acted as a tumor suppressor gene in the development of GC.

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“…C5b9, LDH, TnI, and CK-MB are important burn injury-induced myocardial infarction markers, and their diagnostic utility in patients with myocardial infarctions has been established [26,27]. miR-190b, which can be detected in tissues and blood in human, is an oncogene that promotes tumorigenesis in several cancers through the regulation of genes, such as Bcl-2, PTEN, and IGF-1 [28][29][30]. miR-190b promotes cell proliferation, invasion, and migration but decreases cell apoptosis [30].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the differential expression profile of miRNAs in myocardial tissues of rats with burn injury

Guo

Zhu

Zhang

et al. 2020

Bioscience, Biotechnology, and Biochemistry

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Fifteen percent third-degree burn rat model was used to identify miRNAs that are markers of burn injury-induced myocardial damage. Cardiac tissues were evaluated to determine miRNA profile sequencing. Pearson's correlation analysis was used between miRNAs and injury markers. ROC curve analysis was used to estimate miRNA's sensitivity and specificity for the diagnosis of myocardial damage caused by burn injury. The sequencing analysis revealed 23 differentially expressed miRNAs. Pearson's correlation analysis revealed that rno-miR-190b-3p and C5b9, rno-miR-341, rno-miR-344b-3p and TnI, rno-miR-344b-3p and CK-MB were significantly positively correlated, respectively. ROC curve analysis demonstrated that rno-miR-341, rno-miR-344b-3p, and rno-miR-190b-3p exhibited high sensitivity and specificity for the diagnosis of myocardial damage caused by burn injury. In conclusion, our results suggest that rno-miR-341, rno-miR-344b-3p, and rno-miR-190b-3p have the potential to be used as sensitive and specific biomarkers to diagnose myocardial damage caused by burn injury.

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MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells

Abstract: miR-190b confers radio-sensitivity of GC cells, possibly via negative regulation of Bcl-2.

Cited by 17 publications

References 15 publications

MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4

MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4

LincRNA‐p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β‐catenin signaling pathway

Analysis of the differential expression profile of miRNAs in myocardial tissues of rats with burn injury

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