MicroRNA-21 promotes cell proliferation in human hepatocellular carcinoma partly by targeting HEPN1

Hu, Shuxiang; Tao, Ruiyang; Wang, Shouyu; Wang, Chaoqun; Zhao, Xiankun; Zhao, Hua; Li, Lijuan; Zhu, Shijia; Jiang, Xinghong; Gao, Yuzhen

doi:10.1007/s13277-015-3213-9

Cited by 17 publications

(7 citation statements)

References 26 publications

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“…The HEPN1 gene is another target of miR-21, and its silence induced by miR-21 significantly accelerated the tumor growth of HCC. In addition, mitogen-activated protein kinase-kinase 3 (MAP2K3), reversion-inducing-cysteine-rich protein with kazal motifs (RECK), and programmed cell death 4 (PDCD4) were the direct targets of miR-21, and their expression and functions were notably suppressed in HCC (41,43,44).…”

Section: Downregulation Of Mirnas In Hccmentioning

confidence: 99%

MicroRNAs involved with hepatocellular carcinoma (Review)

Mao

Wang

2015

Oncology Reports

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Hepatocellular carcinoma (HCC) is one of the most common malignancies, which accounts for 90% of primary liver cancer. HCC usually presents with poor outcomes due to the high rates of tumor recurrence and widespread metastasis. However, the underlying mechanism of HCC initiation and progression, which significantly hindered the development of valid approaches for early detection and treatment remain to be elucidated. As a group of small non-coding RNAs, microRNAs (miRNAs) have been demonstrated to be involved in many types of diseases especially human malignancies. Numerous miRNAs are deregulated in HCC, which may shed some light on current investigations. Since miRNAs are stable and detected easily, their ectopic expression has been reported in HCC tissues, serum/plasma and cell lines. As previously described, miRNAs serve as tumor suppressors or oncogenes, indicating that miRNAs may be useful as diagnostic, therapeutic and prognostic markers of HCC. In the present review, we assessed the latest data regarding dysregulated miRNAs in HCC and reviewed the reported functions of these miRNAs as they apply to the diagnosis and prognosis of HCC.

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Section: Downregulation Of Mirnas In Hccmentioning

confidence: 99%

MicroRNAs involved with hepatocellular carcinoma (Review)

Mao

Wang

2015

Oncology Reports

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“…Numerous miRNAs were identified from thousands of cancer related studies serving as promising biomarkers or therapeutic targets (15,16). For instance, miR-21, miR-124, miR-148a and miR-384 have been reported to be involved in the progression of HCC (17)(18)(19)(20). In recent years, emerging studies showed that aberrant expression of long noncoding RNAs (lncRNAs), a class of ncRNAs more than 200 nucleotides in length, was involved in the tumorigenesis and development of various cancer, including HCC (21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-26a inhibits proliferation and metastasis of human hepatocellular carcinoma by regulating DNMT3B-MEG3 axis

Ren

Zhao

et al. 2017

Oncology Reports

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miR-26a is known to play an important oncosuppressive role in HCC. However, its regulatory role and relationship with other non-coding RNAs is less clear. In the present study, we report that the expression levels of miR-26a and long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) were frequently downregulated in HCC tissues compared to matched non-malignant tissues. In addition, the expression levels of miR-26a and MEG3 were negatively correlated with the tumor sizes and TNM clinical stage in HCC patients. Overexpression of miR-26a significantly reduced the capacity of proliferation, invasion and migration of HCC cells. Moreover, we demonstrated that DNA methyltransferase 3b (DNMT3B) was a direct target gene of miR-26a. Overexpression of miR-26a suppressed the expression level of DNMT3B. Inhibited expression of DNMT3B showed similar tumor suppressive effects induced by miR-26a upregulation, and resulted in the upregulation of MEG3. Furthermore, we found that the expression levels of DNMT3B were upregulated in the HCC tissues compared with non-malignant tissues, and it was inversely correlated with miR-26a and MEG3 in HCC tissues. Thus, these results provided a plausible link between the observed reduction of miR-26a and MEG3 in HCCs. Together, the present study added miR-26a/DNMT3B/MEG3 axis to the complex mechanisms of HCC development.

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“…Several miRNAs have been identified to play a critical role in regulating HCC tumorigenesis and metastasis signaling networks [25–28]. Elucidating the underlying mechanisms of miRNA in liver carcinogenesis may improve diagnostic and therapeutic strategies for HCC.…”

Section: Discussionmentioning

confidence: 99%

High expression of miR-105-1 positively correlates with clinical prognosis of hepatocellular carcinoma by targeting oncogene NCOA1

et al. 2017

Oncotarget

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Increasing evidence supports that microRNA (miRNA) plays a significant functional role in cancer progression by directly regulating respective targets. In this study, the expression levels of miR-105-1 and its target gene were analyzed using genes microarray and hierarchical clustering analysis followed by validation with quantitative RT-PCR in hepatocellular carcinoma (HCC) and normal liver tissues. We examined the expression of nuclear receptor coactivator 1 (NCOA1), the potential target gene of miR-105-1, following the transfection of miR-105-1 mimics or inhibitors. Our results showed that miR-105-1 was downregulated in HCC tissues when compared with normal liver tissues and patients with lower miR-105-1 expression had shorter overall survival (OS) and progression free survival (PFS). Moreover, NCOA1 was confirmed to be a direct target of miR-105-1. Furthermore, concomitant high expression of NCOA1 and low expression of miR-105-1 correlated with a shorter median OS and PFS in HCC patients. In conclusion, our results provide the first evidence that NCOA1 is a direct target of miR-105-1 suggesting that NCOA1 and miR-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC patients.

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MicroRNA-21 promotes cell proliferation in human hepatocellular carcinoma partly by targeting HEPN1

Cited by 17 publications

References 26 publications

MicroRNAs involved with hepatocellular carcinoma (Review)

MicroRNAs involved with hepatocellular carcinoma (Review)

MicroRNA-26a inhibits proliferation and metastasis of human hepatocellular carcinoma by regulating DNMT3B-MEG3 axis

High expression of miR-105-1 positively correlates with clinical prognosis of hepatocellular carcinoma by targeting oncogene NCOA1

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