MicroRNA-454 contributes to sustaining the proliferation and invasion of trophoblast cells through inhibiting Nodal/ALK7 signaling in pre-eclampsia

MiR‐342‐3p inhibition promotes cell proliferation and invasion by directly targeting ID4 in pre‐eclampsia

“…26 Similar results have been found in studies investigating miR-454 and miR-144, which increased the proliferation and invasion, induced apoptosis of trophoblast cells. 27,28 Our results demonstrated that miR-342-3p was upregulated in PE placentas, which was consistent with Choi et al's finding. 18 Hromadnikova et al…”

MicroRNA–mRNA Networks in Pregnancy Complications: A Comprehensive Downstream Analysis of Potential Biomarkers

“…, let-7c, miR-103, miR-122, miR-1233, miR-125a, miR-125b, miR-130b, miR-1323, miR-133a, miR-136, miR-141, miR-143, miR-152, miR-155, miR-181a, miR-182, miR-192, miR-193b, miR-21, miR-210, miR-215, miR-221, miR-24, miR-26a, miR-29a, miR-342, miR-423, miR-494, miR-495, miR-512, miR-515, miR-516a, miR-516b, miR-517b, miR-517c, miR-518b, miR-518e, miR-518f, miR-519a, miR-519d, miR-520a, miR-520c, miR-520d, miR-520g, miR-520h, miR-521, miR-525, miR-526b, miR-542, miR-574, miR-628, miR-629, miR-650, miR-758, miR-92aUpregulated Maternal circulation [41,45-67] miR-185, let-7d, miR-126, miR-1260, miR-1272, miR-144, miR-196b, miR-19b1, miR-223, miR-320c, miR-92a1, miR-766, miR-573, miR-409, miR-18a Downregulated Maternal circulation [41,49,51,60,61,63,66,68,69] let-7c, let-7d, miR-122, miR-125b, miR-134, miR-136, miR-141, miR-148a, miR-151, miR-152, miR-155, miR-16, miR-17, miR-181a, miR-193b-star, miR-20a, miR-20b, miR-21, miR-210, miR-221, miR-222, miR-25, miR-26b, miR-27a-star, miR-296, miR-29b, miR-30a-star, miR-31, miR-320a, miR-335, miR-362, miR-365a, miR-423, miR-431, miR-4421, miR-516b, miR-517-star, miR-518a, miR-518b, miR-519e, miR-520a, miR-524, miR-584, miR-638 Upregulated Placenta [10,45,62,66,70-89] miR-542, miR-584, miR-17, miR-18a, miR-223, miR-19b1, miR-144, miR-126, miR-92a1, miR-1247, miR-204, miR-590, miR-1, miR-363, miR-150, miR-218, miR-32, miR-328, miR-625, miR-19a, miR-18b, miR-154, miR-411, miR-101, miR-195, miR-135b, miR-454, miR-374, miR-379, miR-149, miR-377, miR-10b, miR-450, miR-34c, miR-500, miR-139 DownregulatedPlacenta[66,73,87,88,[90][91][92][93][94][95][96][97][98] …”

Roles of noncoding RNAs in preeclampsia

“… [ 78 ] miR-144 placenta downregulated PTEN miR-144 induced significant increase in cell proliferation, migration, invasion, and decrease in cell apoptosis, and also affected the cell cycles [ 79 ] miR-144-3p placenta downregulated Cox-2 Downregulation of miR-144-3p led to systemic inflammation and endothelial cell injury [ 80 ] miR-942 plasma downregulated ENG Decreased miR-942 expression decreased the invasive ability of TEV-1 cells, and inhibited the HUVEC angiogenesis assay [ 81 ] miR-134 placenta upregulated ITGB1 MiR-134 suppressed the infiltration of trophoblast cells by targeting ITGB1 [ 82 ] miR-362-3p placenta upregulated Pax3 miR-362-3p/Pax3 axis regulates cell viability, migration and invasion of HTR8/SVneo cells under hypoxia. [ 83 ] miR-454 placenta downregulated EPHB4/ALK7 MiR-454 promotes the proliferation and invasion of trophoblast cells, and inhibit the apoptosis [ 84 , 85 ] miR-30a-3p placenta upregulated IGF-1 the over-expression of miR-30a-3p alter the invasive capacity of JEG-3 cells and induce the apoptosis of HTR-8/SVneo cells [ 86 ] miR-31-5p serum upregulated eNOS NF-κB-responsive miR-31-5p elicits endothelial dysfunction, hypertension, and vascular remodeling via post-transcriptional down-regulation of eNOS [ 87 ] miR-423–5p plasma upregulated IGF2BP1 MiR-423-5p inhibited migration, invasion and proliferation as well as induced apoptosis in HTR-8/SVneo cells. [ ...…”

“… [ 97 ] miR-145-5p placenta downregulated FLT1/Cyr61 miR-145-5p promoted trophoblast cell growth and invasion [ 98 , 99 ] miR-30b placenta upregulated MXRA5 miR-30b might contribute to PE through inhibiting cell viability, invasion while inducing apoptosis of placental trophoblast cells via MAPK pathway by targeting MXRA5. [ 100 ] miR-454 placenta downregulated ALK7/EPHB4 miR-454 promotes the proliferation and invasion of trophoblast cells by inhibiting EPHB4 /ALK7 [ 84 , 85 ] miR-200a plasma upregulated EG-VEGF/TTR miR-200a suppressed primary cilia formation and inhibited trophoblast invasion. [ 101 , 102 ] miR-548c-5p placenta/ serum exosome downregulated PTPRO miR-548c-5p could inhibit the proliferation and activation of LPS-stimulated macrophages and decrease levels of inflammatory cytokines [ 103 ] miR-342-3p placenta upregulated PDGFRA/ID4 miR-342-3p was proposed to inhibit the proliferation, migration, invasion and G1/S phase transition of HTR8/SVneo cells [ 104 , 105 ] miR-431 placenta upregulated ZEB1 miR-431 inhibited the migration and invasion of trophoblastic cells [ 106 ] miR-221-3p placenta downregulated THBS2 miR-221-3p overexpression inhibited apoptosis, increased cell population at S phase, and decreased cell population at G0/G1 phase of HTR-8/SVneo cells [ 107 ] miR-152 placenta upregulated VEGF ...…”