MicroRNA as Upcoming Biomarkers for Psychiatric Conditions

Narahari, Anoop; Hussain, Mariyah; Sreeram, Venkatesh

doi:10.4172/2572-0791.1000103

Cited by 18 publications

(26 citation statements)

References 13 publications

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“…These two exosomal miRNAs may have the potential to be a biomarker for atherosclerosis diagnosis. Meanwhile, miRNAs can be delivered from the donor cells to the recipient cells by exosomes (18). So whether overexpressed miR-92a and miR-30e can be functionally delivered to target cells or not need to be further examined.…”

Section: Discussionmentioning

confidence: 99%

MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1

Wang

Zhang

et al. 2019

Mol Med Report

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Atherosclerosis is a chronic disease characterized by the accumulation of lipids and fibrous elements in the large arteries, which is the principal cause of coronary artery disease. Dysregulated exosomal microRNA (miRNA) levels in serum have been identified in patients with various diseases, including CAD. In the present study, nine candidate miRNAs were detected in the plasma exosome from 42 patients with coronary atherosclerosis, and a higher expression of miR-30e and miR-92a was identified in patients. Following bioinformatics analysis and confirmation through immunoblotting, it was demonstrated that ATP binding cassette (ABC)A1 is a direct target of miR-30e, and miR-92a. Furthermore, a negative correlation was identified between plasma miR-30e and ABCA1, or miR-30e and cholesterol. Thus, the results of the present study suggest that the miR-30e level in exosomes from serum may have the potential to be a novel diagnostic biomarker for coronary atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1

Wang

Zhang

et al. 2019

Mol Med Report

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“…A single miRNA can modulate thousands of genes by recognizing complementary sequences at the end of 3 ′ UTR of the target mRNA. Endogenous miRNAs influence numerous processes taking place in cells, e.g., proliferation, DNA repair, cell differentiation, metabolism and apoptosis, as well as regulate inflammatory processes [33]. In our earlier paper, we pointed to the probable significance of miRNA-370, miRNA-411, miRNA-433, miRNA-487b, and miRNA-539 for the aetiology and course of depression [34].…”

Section: Epigenetics In Depressionmentioning

confidence: 96%

“…In our earlier paper, we pointed to the probable significance of miRNA-370, miRNA-411, miRNA-433, miRNA-487b, and miRNA-539 for the aetiology and course of depression [34]. Meanwhile, Narahari et al [33] identify miRNA-16 as a posttranscriptional repressor of the serotonin transporter (SERT).…”

Section: Epigenetics In Depressionmentioning

confidence: 99%

Epigenetic Mechanisms in the Neurodevelopmental Theory of Depression

Talarowska

2020

Depression Research and Treatment

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The genome (genes), epigenome, and environment work together from the earliest stages of human life to produce a phenotype of human health or disease. Epigenetic modifications, including among other things: DNA methylation, modifications of histones and chromatin structure, as well as functions of noncoding RNA, are coresponsible for specific patterns of gene expression. This refers also to mental disorders, including depressive disorders. Early childhood experiences accompanied by severe stressors (considered a risk factor for depression in adult life) are linked with changes in gene expression. They include genes involved in a response to stress (hypothalamic-pituitary-adrenal axis, HPA), associated with autonomic nervous system hyperactivity and with cortical, and subcortical processes of neuroplasticity and neurodegeneration. These are, among others: gene encoding glucocorticoid receptor, FK506 binding protein 5 gene (FKBP5), gene encoding arginine vasopressin and oestrogen receptor alpha, 5-hydroxy-tryptamine transporter gene (SLC6A4), and gene encoding brain-derived neurotrophic factor. How about personality? Can the experiences unique to every human being, the history of his or her development and gene-environment interactions, through epigenetic mechanisms, shape the features of our personality? Can we pass on these features to future generations? Hence, is the risk of depression inherent in our biological nature? Can we change our destiny?

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“…Hypothesizing exosomal miRNAs in schizophrenia are potential biomarkers MiRNAs have been shown to be potential biomarkers in various neurodegenerative and psychiatric disorders, such as Alzheimer's dementia, Parkinson's disease and schizophrenia [28,29]. These miRNAs are present in various body fluids, like CSF, serum, saliva and urine.…”

Section: The Hypothesismentioning

confidence: 99%