MicroRNA BIOGENESIS, FUNCTIONALITY AND CANCER RELEVANCE

Kusenda, Branislav; Mráz, Marek; Mayer, Jiří; Pospı́šilová, Šárka

doi:10.5507/bp.2006.029

Cited by 133 publications

(74 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MiRNAs are post-transcriptional regulators that bind to complementary sequences on target mRNAs, usually resulting in translational repression or target degradation and gene silencing (Kusenda et al, 2006;Bartel, 2009). The identification of miRNAs which are involved in regulating expression of target genes in ovarian cancer might be important in understanding molecular mechanism of this disease.…”

Section: Discussionmentioning

confidence: 99%

Identification of Genes and MicroRNAs Involved in Ovarian Carcinogenesis

Wan

Lv²,

Guan³

2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

MicroRNAs (miRNAs) play roles in the clinic, both as diagnostic and therapeutic tools. The identification of relevant microRNAs is critically required for ovarian cancer because of the prevalence of late diagnosis and poor treatment options currently. To identify miRNAs involved in the development or progression of ovarian cancer, we analyzed gene expression profiles downloaded from Gene Expression Omnibus. Comparison of expression patterns between carcinomas and the corresponding normal ovarian tissues enabled us to identify 508 genes that were commonly up-regulated and 1331 genes that were down-regulated in the cancer specimens. Function annotation of these genes showed that most of the up-regulated genes were related to cell cycling, and most of the down-regulated genes were associated with the immune response. When these differentially expressed genes were mapped to MiRTarBase, we obtained a total of 18 key miRNAs which may play important regulatory roles in ovarian cancer. Investigation of these genes and microRNAs should help to disclose the molecular mechanisms of ovarian carcinogenesis and facilitate development of new approaches to therapeutic intervention.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of Genes and MicroRNAs Involved in Ovarian Carcinogenesis

Wan

Lv²,

Guan³

2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…MiRNAs either bind to their target gene mRNA and promote their degradation and/or inhibit protein translation (14,15). The primary transcripts of miRNA genes (pri-miRNA) are processed in the nucleus by the Microprocessor complex consisting of DGCR8 and Drosha to ϳ70-nucleotide hairpin structures called pre-miRNAs (16 -18).…”

Section: Multiple Endocrine Neoplasia Type I (Men1)mentioning

confidence: 99%

Menin Is Required for Optimal Processing of the MicroRNA let-7a

Gurung

Muhammad

Hua

2014

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Menin represses pancreatic beta cell proliferation. Results: Menin promotes processing of let-7a, whose target IRS2 plays an important role in insulin signaling and beta cell proliferation. Conclusion: Menin represses beta cell proliferation partly via regulation of miRNA biogenesis. Significance: Understanding how menin represses beta cell proliferation will aid toward improving therapies targeting endocrine tumors and metabolic diseases including diabetes.

show abstract

“…For example, the maturation of pre-miR-38 may be temporally regulated in C. elegans since miR-38 is expressed only in the embryo, whereas the pre-miR-38 is ubiquitously detected. It is also possible that the nuclear export of pre-miR-38 may be controlled by a specific developmental signal or that Dicer processing may be repressed until a certain stage; some of these deregulations have been found to contribute to cancer development[51],[52]. Indeed, a number of miRNAs are down-regulated in cancer though their pri-miRNAs are expressed at a relatively high level, indicating that the cropping step may be controlled dynamically during cell differentiation and tumorigenesis.…”

Section: Mirna Biogenesismentioning

confidence: 99%

Single-nucleotide polymorphisms among microRNA: big effects on cancer

Song

Chen²

2011

Chin J Cancer

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. Many miRNAs are found to play a significant role in cancer development either as tumor suppressor genes or as oncogenes. Examination of tumor-specific miRNA expression profiles in diverse cancers has revealed widespread deregulation of these molecules, whose loss and overexpression respectively have diagnostic and prognostic significance. Genetic variations, mostly single-nucleotide polymorphisms (SNPs) within miRNA sequences or their target sites, have been found to be associated with many kinds of cancers. In this review, we summarize the current knowledge of miRNAs including their biogenesis and role in cancer development, and finally, how SNPs among miRNAs affect miRNA biogenesis and contribute to cancer.

show abstract

MicroRNA BIOGENESIS, FUNCTIONALITY AND CANCER RELEVANCE

Cited by 133 publications

References 93 publications

Identification of Genes and MicroRNAs Involved in Ovarian Carcinogenesis

Identification of Genes and MicroRNAs Involved in Ovarian Carcinogenesis

Menin Is Required for Optimal Processing of the MicroRNA let-7a

Single-nucleotide polymorphisms among microRNA: big effects on cancer

Contact Info

Product

Resources

About