MicroRNA Regulation and Cardiac Calcium Signaling

Harada, Masafumi; Luo, Xiaobin; Murohara, Toyoaki; Yang, Baofeng; Dobrev, Dobromir; Nattel, Stanley

doi:10.1161/circresaha.114.301798

Cited by 114 publications

(56 citation statements)

References 120 publications

(182 reference statements)

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“…10-12 Of special interest are the contributions of miRNAs to a wide range of cardiac electrical remodeling processes. 10 Recent studies have demonstrated that Cav1.2, which is a target of miR-328 and miR-21, was markedly decreased in cardiomyocytes with chronic AF, accompanied by a decrease in ICa.L, suggesting that miR-328 and miR-21 contribute to AF-induced electrical remodeling. 13,14 Post-transcriptional regulation of Kir2.1 (KCNJ2) by miR-1 and miR-26 was also demonstrated in AF cardiomyocytes.…”

Section: Cell Isolation and Culturementioning

confidence: 99%

Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K+ Channel, IK.ACh

Miyamoto

Iwata

Nakada

et al. 2016

Circ J

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Section: Cell Isolation and Culturementioning

confidence: 99%

Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K+ Channel, IK.ACh

Miyamoto

Iwata

Nakada

et al. 2016

Circ J

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“…While past studies have focused on the Ca 2+ -dependent modulation of protein effectors, it is now becoming clear that Ca 2+ signals can also modulate expression and activity of ncRNAs such as microRNAs (Choi et al, 2014, Gstir et al, 2014, Harada et al, 2014, increasingly recognised as important players in the control of gene expression during embryonic development, by regulating processes such as cell proliferation, differentiation and apoptosis (Moreno-Moya et al, 2014).…”

Section: Ca 2+ Signals -Modulators Of Physiological Processesmentioning

confidence: 99%

Calcium signals regulated by NAADP and two-pore channels - their role in development, differentiation and cancer

Parrington¹,

Lear²,

Hachem³

2015

Int. J. Dev. Biol.

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“…It has been reported that miR-98 and miR-9 are closely associated with the development of myocardial hypertrophy (17). The newly discovered miRNA family miR-181 has been found to promote tumor proliferation, invasion and migration (18).…”

Section: Discussionmentioning

confidence: 99%

Association between miR-181b and PKG 1 in myocardial hypertrophy and its clinical implications

Zhong

Yang

Cao

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of this study was to explore the microRNA (miR)-181b expression in myocardial hypertrophy and to investigate its association with cGMP-dependent protein kinase type I (PKG 1) in an in vitro model. The miR-181b level in the peripheral blood was determined in patients with myocardial hypertrophy, and an in vitro model was established via phenylephrine (PE) treatment. Reverse transcription-quantitative polymerase chain reaction analysis and western blotting were performed to detect the expression levels of miR-181b, PKG 1 and hypertrophy-related genes. The results revealed that the expression of miR-181b was elevated in the peripheral blood of patients with myocardial hypertrophy, and this may have contributed to the pathology and progression of the disease. When the primary myocardial cells were treated with PE, microscopic observation and flow cytometry revealed significant hypertrophy. Furthermore, upregulation of myocardial hypertrophy-related genes, including β-myosin heavy chain, α-sarcomeric actinin and atrial natriuretic peptide, was observed. The miR-181b expression level in the PE-treated cells was elevated, while the mRNA and protein expression levels of PKG 1 were decreased, indicating a negative correlation between miR-181b and PKG 1 in myocardial hypertrophy. In addition, when the PE-treated primary myocardial cells were transfected with miR-181b inhibitor, the reduced PKG 1 expression was restored and the myocardial hypertrophy alleviated, as indicated by the reduced cellular sizes and decreased expression levels of the myocardial hypertrophy-related genes. In conclusion, miR-181b expression has been shown to be upregulated in myocardial hypertrophy, and this may play a role in the pathogenesis of the disease by regulating the expression of PKG 1. The present findings suggest that miR-181b is a promising molecular indicator for the clinical diagnosis and treatment of cardiac hypertrophy.

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MicroRNA Regulation and Cardiac Calcium Signaling

Cited by 114 publications

References 120 publications

Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K<sup>+</sup> Channel, <i>I</i><sub>K.ACh</sub>

Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K<sup>+</sup> Channel, <i>I</i><sub>K.ACh</sub>

Calcium signals regulated by NAADP and two-pore channels - their role in development, differentiation and cancer

Association between miR-181b and PKG 1 in myocardial hypertrophy and its clinical implications

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