MicroRNAs and exosomes in depression: Potential diagnostic biomarkers

Tavakolizadeh, Jahanshir; Roshanaei, Kambiz; Salmaninejad, Arash; Yari, Reza; Nahand, Javid Sadri; Sarkarizi, Hoda Khoshdel; Mousavi, Seyed Mojtaba; Salarinia, Reza; Rahmati, Majid; Mousavi, Seyed Farshid; Mokhtari, Ryan; Mirzaei, Hamed

doi:10.1002/jcb.26599

Cited by 136 publications

(102 citation statements)

References 90 publications

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“…miRNAs are a negative regulator of translation by binding to mRNAs 3′‐UTR . Emerging evidence suggested that miRNAs might play the key role in regulating the process of neurotrophin, serotonergic signalling and synaptic plasticity process . Our results showed that chronic stress could up‐regulate the levels of miR‐15b‐5p, miR‐144‐3p and miR‐879‐5p expression (Figures ) as well as down‐regulate the expression of Gad1, VGAT and GAT‐3 genes and proteins, which impaired GABA tone.…”

Section: Discussionmentioning

confidence: 62%

The molecular mechanism underlying GABAergic dysfunction in nucleus accumbens of depression‐like behaviours in mice

Zhang

Wang

et al. 2019

J Cellular Molecular Medi

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Depression is the most frequent psychiatric disorder in the world. Recent evidence has shown that stress‐induced GABAergic dysfunction in the nucleus accumbens (NAc) contributed to the pathophysiology of depression. However, the molecular mechanisms underlying these pathological changes remain unclear. In this study, mice were constantly treated with the chronic unpredictable mild stress (CUMS) till showing depression‐like behaviours expression. GABA synthesis, release and uptake in the NAc tissue were assessed by analysing the expression level of genes and proteins of Gad‐1, VGAT and GAT‐3 by qRT‐PCR and Western blotting. The miRNA/mRNA network regulating GABA was constructed based on the bioinformatics prediction software and further validated by dual‐luciferase reporter assay in vitro and qRT‐PCR in vivo, respectively. Our results showed that the expression level of GAT‐3, Gad‐1 and VGAT mRNA and protein significantly decreased in the NAc tissue from CUMS‐induced depression‐like mice than that of control mice. However, miRNA‐144‐3p, miRNA‐879‐5p, miR‐15b‐5p and miRNA‐582‐5p that directly down‐regulated the expression of Gad‐1, VGAT and GAT‐3 were increased. In the mRNA/miRNA regulatory GABA network, Gad‐1 and VGAT were directly regulated by binding seed sequence of miR‐144‐3p, and miR‐15b‐5p, miR‐879‐5p could be served negative post‐regulators by binding to the different sites of VGAT 3′‐UTR. Chronic stress causes the impaired GABA synthesis, release and uptake by up‐regulating miRNAs and down‐regulating mRNAs and proteins, which may reveal the molecular mechanisms for the decreased GABA concentrations in the NAc tissue of CUMS‐induced depression.

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Section: Discussionmentioning

confidence: 62%

The molecular mechanism underlying GABAergic dysfunction in nucleus accumbens of depression‐like behaviours in mice

Zhang

Wang

et al. 2019

J Cellular Molecular Medi

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“…; Tavakolizadeh et al . ). Previously, we showed that a variety of miRNAs are involved in glioblastoma pathogenesis (Masoudi et al .…”

Section: Astrocytoma and Glioblastomamentioning

confidence: 97%

Genetic and epigenetic contribution to astrocytic gliomas pathogenesis

Khani

Nasri

Chamani

et al. 2018

Journal of Neurochemistry

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Astrocytic gliomas are the most common and lethal form of intracranial tumors. These tumors are characterized by a significant heterogeneity in terms of cytopathological, transcriptional, and (epi)genomic features. This heterogeneity has made these cancers one of the most challenging types of cancers to study and treat. To uncover these complexities and to have better understanding of the disease initiation and progression, identification, and characterization of underlying cellular and molecular pathways related to (epi)genetics of astrocytic gliomas is crucial. Here, we discuss and summarize molecular and (epi)genetic mechanisms that provide clues as to the pathogenesis of astrocytic gliomas.

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“…MicroRNAs are small non‐coding RNAs which act as epigenetic regulators . These molecules play critical roles in regulation of gene expression in the RNA and protein levels .…”

Section: Microrna and Exosome‐based Vaccinementioning

confidence: 99%

Influenza vaccine: Where are we and where do we go?

Keshavarz

Mirzaei

Salemi

et al. 2018

Reviews in Medical Virology

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Summary The alarming rise of morbidity and mortality caused by influenza pandemics and epidemics has drawn attention worldwide since the last few decades. This life‐threatening problem necessitates the development of a safe and effective vaccine to protect against incoming pandemics. The currently available flu vaccines rely on inactivated viral particles, M2e‐based vaccine, live attenuated influenza vaccine (LAIV) and virus like particle (VLP). While inactivated vaccines can only induce systemic humoral responses, LAIV and VLP vaccines stimulate both humoral and cellular immune responses. Yet, these vaccines have limited protection against newly emerging viral strains. These strains, however, can be targeted by universal vaccines consisting of conserved viral proteins such as M2e and capable of inducing cross‐reactive immune response. The lack of viral genome in VLP and M2e‐based vaccines addresses safety concern associated with existing attenuated vaccines. With the emergence of new recombinant viral strains each year, additional effort towards developing improved universal vaccine is warranted. Besides various types of vaccines, microRNA and exosome‐based vaccines have been emerged as new types of influenza vaccines which are associated with new and effective properties. Hence, development of a new generation of vaccines could contribute to better treatment of influenza.

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MicroRNAs and exosomes in depression: Potential diagnostic biomarkers

Cited by 136 publications

References 90 publications

The molecular mechanism underlying GABAergic dysfunction in nucleus accumbens of depression‐like behaviours in mice

The molecular mechanism underlying GABAergic dysfunction in nucleus accumbens of depression‐like behaviours in mice

Genetic and epigenetic contribution to astrocytic gliomas pathogenesis

Influenza vaccine: Where are we and where do we go?

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