MicroRNAs: Potential candidates for diagnosis and treatment of colorectal cancer

Moridikia, Abdullah; Mirzaei, Hamed; Sahebkar, Amirhossein; Salimian, Jafar

doi:10.1002/jcp.25801

Cited by 181 publications

(173 citation statements)

References 134 publications

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“…It has been demonstrated that miRNAs are crucial for the occurrence and development of CRC (29,30). Through bioinformatics analysis, we identified CXCL11 as a potential target of miR-144.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑144 mediates chronic inflammation and tumorigenesis in colorectal cancer progression via regulating C‑X‑C motif chemokine ligand 11

Han

Feng

Yu³

et al. 2018

Exp Ther Med

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Colorectal cancer (CRC) is one of the most common malignancies worldwide. The aim of the present study was to investigate the expression of microRNA-144 (miR-144) and C-X-C motif chemokine ligand 11 (CXCL11) in CRC and their association. Data from Gene Expression Omnibus (GEO) DataSets were analyzed to obtain the expression profile of CXCL11 in CRC. Subsequently, serum samples were collected from 65 subjects, including 39 patients with CRC and 26 controls; CRC and adjacent normal tissues were collected from all 39 CRC patients and the expression of CXCL11 was measured in these specimens. After searching for the potential regulator of CXCL11 through bioinformatics analysis, the levels of miR-144 in the clinical specimens were also detected. Finally, the regulatory association between miR-144 and CXCL11 was certified via the dual-luciferase reporter assay. Microarray data and bioinformatics analysis demonstrated that CXCL11 was significantly upregulated in CRC tissues and miR-144 was a potential regulator of CXCL11. In line with this finding, the expression of CXCL11 was significantly increased in the serum and tumor samples of patients with CRC, while that of miR-144 was downregulated. Dual-luciferase reporter assay revealed that miR-144 directly targets the 3′-untranslated region of CXCL11 mRNA to regulate its expression. These results demonstrated that enhanced CXCL11 expression in patients with CRC was associated with reduced miR-144 expression. The results of the present study may indicate a novel regulatory role of miR-144 in CRC through CXCL11 downregulation.

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“…It has been demonstrated that miRNAs are crucial for the occurrence and development of CRC (29,30). Through bioinformatics analysis, we identified CXCL11 as a potential target of miR-144.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑144 mediates chronic inflammation and tumorigenesis in colorectal cancer progression via regulating C‑X‑C motif chemokine ligand 11

Han

Feng

Yu³

et al. 2018

Exp Ther Med

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“…MiRNAs regulate several biological processes such as growth, development, angiogenesis, stem cell renewal, and differentiation (Banikazemi et al, ; Golabchi et al, ; Jafari et al, ; Masoudi, Mehrabian, & Mirzaei, ; H. Mirzaei, Ferns, Avan, & Mobarhan, ; H. Mirzaei, Yazdi, Salehi, & Mirzaei, ; Saeedi Borujeni et al, ; Simonian, Mosallayi, & Mirzaei, ; Tavakolizadeh et al, ). Deregulation of these molecules is associated with initiation and progression of many diseases such as cancer, diabetes, stroke, neurodegenerative diseases, and cardiovascular diseases (Gholamin et al, , ; Hoseini et al, ; H. Mirzaei, Gholamin, et al, ; H. R. Mirzaei, Sahebkar, et al, ; H. Mirzaei, Naseri, et al, ; H. Mirzaei, ; H. Mirzaei, Fathullahzadeh, et al, ; H. Mirzaei, Momeni, et al, ; H. R. Moridikia et al, ; Rabieian et al, ; Rashidi, Malekzadeh, Goodarzi, Masoudifar, & Mirzaei, ; Rashidi, Hoseini, Sahebkar, & Mirzaei, ). Recently, alterations in some specific miRNAs in AD brains have been revealed by scrutinizing the miRNA expression profiles.…”

Section: Mirnas As Therapeutic Candidate In Admentioning

confidence: 99%

Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy

Iranifar

Seresht

Momeni

et al. 2018

Journal Cellular Physiology

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Exosomes are biological nanocarriers which could be involved in a variety of basic physiological events. They exert their effects via targeting their cargos (i.e., DNAs, messenger RNAs, microRNAs [miRNAs], and proteins) to host cells, which led to change behaviors of recipient cells. One of the important aspects of exosomes is the roles of them in disease conditions. Increasing evidence indicated that exosomes are one of the main players in Alzheimer's disease (AD) pathogenesis. Hence, it seems that these nanocarriers could be used as diagnostic and therapeutic biomarkers in AD treatment. Another important player in AD pathogenesis is miRNA. MiRNAs are short noncoding RNAs which exert their effects as epigenetic regulators. These molecules involved in different stages of AD. Therefore, miRNAs could be used as prognostic, diagnostic, and therapeutic biomarkers in AD. Here, we summarized various roles of exosomes and application of them in AD pathogenesis. Moreover, we highlighted the utilization of miRNAs as a therapeutic option in AD therapy.

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“…miRNAs are a group of noncoding RNAs, which act epigenetic players. Given that these molecules can affect a wide range of biological processes, such as growth, angiogenesis, differentiation, metastasis, and differentiation of stem cells . Given that deregulation of miRNAs are related with initiation and progression of a large number of diseases, such as cancer, diabetes, stroke, cardiovascular diseases, viral infections, and degenerative diseases .…”

Section: Mirna and Response To Therapy In Leukemiamentioning

confidence: 99%

MicroRNAs and response to therapy in leukemia

Mirzaei

Abadi

Razi

et al. 2019

J of Cellular Biochemistry

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A variety of epigenetic factors involved in leukemia pathogenesis. Among various epigenetic factors, microRNAs (miRNAs) have emerged as important players, which affect a sequence of cellular and molecular signaling pathways. Leukemia is known as progressive cancer, which is related to many health problems in the world. It has been shown that the destruction of the blood‐forming organs could lead to abnormal effects on the proliferation and development of leukocytes and their precursors. Despite many attempts for approved effective and powerful therapies for patients with leukemia, finding and developing new therapeutic approaches are required. One of the important aspects of leukemia therapy, identification of underlying cellular and molecular mechanisms involved in the pathogenesis of leukemia. Several miRNAs (ie, miR‐103, miR‐101, mit‐7, let‐7i, miR‐424, miR‐27a, and miR‐29c) and play major roles in response to therapy in patients with leukemia. miRNAs exert their effects by targeting a variety of targets, which are associated with response to therapy in patients with leukemia. It seems that more understanding about the roles of miRNAs in response to therapy in patients with leukemia could contribute to better treatment of patients with leukemia. Here, for the first time, we summarized various miRNAs, which are involved in response to therapy in the treatment patients with leukemia.

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MicroRNAs: Potential candidates for diagnosis and treatment of colorectal cancer

Cited by 181 publications

References 134 publications

MicroRNA‑144 mediates chronic inflammation and tumorigenesis in colorectal cancer progression via regulating C‑X‑C motif chemokine ligand 11

MicroRNA‑144 mediates chronic inflammation and tumorigenesis in colorectal cancer progression via regulating C‑X‑C motif chemokine ligand 11

Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy

MicroRNAs and response to therapy in leukemia

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