Microsatellite analysis reveals deletion of a large region at chromosome 8p in conventional renal cell carcinoma

Abstract

Loss of heterozygosity (LOH) at chromosome 8p is associated with the progression of conventional (non‐papillary) renal cell carcinomas (RCC). To determine the tumor suppressor gene locus, we carried out a deletion mapping of chromosome 8p at 10 microsatellite loci in 96 RCCs. LOH occurred in 32% of the tumors. The smallest overlapping region of deletion at chromosome 8p11.2–p23.1 corresponds to approximately 34‐cM genetic distance. No small interstitial deletion was seen. Int. J. Cancer 80:22–24, 1999. © 1999 Wiley‐Liss, Inc.

An overview of renal cell cancer: Pathology and genetics

“…The relationship of leiomyomatous renal cell carcinoma and clear cell papillary renal cancer based on the presence or absence of VHL mutation and/or 3p losses is currently controversial. Apart from the VHL inactivation as an initiating event in clear cell renal cancer, many different genetic alterations have been reported for this tumor type, some of them associated with prognosis [55][56][57][58][59][60][61][62][63][64][65][66][67].…”

Chromosomal Alterations in Hepatocellular Nodules by Comparative Genomic Hybridization: High-Grade Dysplastic Nodules Represent Early Stages of Hepatocellular Carcinoma

“…Candidate tumor suppressor genes located on chromosome 8p may be FEZ1, a recently described cancer-related leucine zipper motif gene that showed altered expression in multiple tumor types (Ishii et al, 1999). 8pϪ has also been suggested to play a role in tumor progression in HCC (Boige et al, 1997;Guan et al, 2000) as well as in oral (Ishwad et al, 1999), renal (Schullerus et al, 1999), and breast carcinoma (Radford et al, 1995). 8pϪ is often found together with 8qϩ, a finding that is normally interpreted as an isochromosome 8q (Mertens et al, 1997).…”

Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients

“…The involvement of 8p losses in initiation or progression of HCC is currently not established. Indeed, in HCC as well as in oral and renal carcinoma, 8p loss has been associated with tumor progression, while it has been involved in the initiation process in breast carcinoma (Boige et al, 1997;Ishwad et al, 1999;Schullerus et al, 1999;Radford et al, 1995). In the current report, a gain of 8q represents a frequent event (47%), almost systematically associated with loss of 8p (in 93% of the cases, P50.001).…”