Microscopic changes in the hypophysis of the albino rat following exposure to cold, and their relationship to the physiology of secretion

Quantitative Studies of Cell Types in the Rat Hypophysis Following Unilateral Adrenalectomy

“…This change was in the anterior lobe, since the pars intermedia and pars nervosa maintained a uniform size. This is in accordance with the observations made by Baillif (1938). Histological observations of the hypophyses of rats exposed to cold also confirm his findings that enlargement of the anterior lobe is due to increase in size of blood sinusoids, more numerous colloid vesicles and possible increase in size of basophiles.…”

“…Histological observations of the hypophyses of rats exposed to cold also confirm his findings that enlargement of the anterior lobe is due to increase in size of blood sinusoids, more numerous colloid vesicles and possible increase in size of basophiles. Extreme disintegration of the anterior lobe observed by Baillif (1938) under severe exposure to cold was not noted under the present experimental conditions, nor was cellular disintegration evident. Although no specific counts of mitptic index were made, more mitoses seemed to be present in the rats exposed to cold.…”

Histological and Histochemical Studies on the Rat Pituitary Pars Intermedia

“…For example, early reports by ITANO (1936) and BAILLIF (1938) dealing with the rat pars intermedia, indicated morphologically the secretory activity of this tissue, but no physiological correlation with its fine structure could be established. A fact that the probable secretion from the pars intermedia might stimulate the melanophores of the frog skin was well known, but it is still doubted whether the control on the pigment metabolism by the intermedia hormone might occur in mammalia also.…”