“…Moreover, the micro/nano-structural substrates of different sizes and shapes [ 7 , 8 ] prepared by different processing methods (top-down, bottom-up) have high SERS enhancement factors and can be used for medical detection. At present, microstructural components, such as micro-nano gratings [ 9 , 10 , 11 , 12 , 13 , 14 ], polarizers, and lenses, can be completed by technologies such as nano-imprint, exposure, and development [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. However, there is a problem of material selection if etching is used for microstructure fabrication.…”