Microstructure, mechanical properties, in vitro degradation and cytotoxicity evaluations of Mg–1.5Y–1.2Zn–0.44Zr alloys for biodegradable metallic implants

Cytocompatibility and Hemolysis of AZ31B Magnesium Alloy with Si-containing Coating

“…The phenomenon indicates that the degradation products gradually react with the cells and influence the growth of the cells. The difference between the present study and other works [29,30] is that the extraction time was taken as the influence factor in this study while a diluted concentration was taken in the cited references. The degradation product of the coated samples showed minimal cytotoxicity in the indirect MTT assay.…”

In vitro and in vivo cytocompatibility evaluation of biodegradable magnesium-based stents: a review

“…However, protein adsorption on the sample surface retards the degradation in vivo. Pretreatment of Mg-based samples is a critical step for initial cell adhesion and survival on sample surfaces in the direct culture assays [26,51,69,71,79]. The pretreatment usually consists of a 24 h incubation at 37°C, 5% CO 2 , in solutions like simulated body fluid (SBF) and Dulbecco's Modified eagle medium (DMEM).…”

“…Many studies indicated that extracts from Mg alloys have little or no effect on cell viability by utilizing the indirect culture assay [79,[105][106][107]. Similarly, it is obvious that the test system is static compared to in vivo condition as mentioned above [46,62,64,[101][102][103][104], that is, it cannot adapt to the changes in the environment of the degradable Mg-based stent as the human body does.…”

The role of titania on the microstructure, biocorrosion and mechanical properties of Mg/HA-based nanocomposites for potential application in bone repair

“…To overcome the rapid degradation rate of Mg-based alloys, various techniques were introduced in recent studies. Alloying Mg with safe elements such as Ca [19], Zn [20] and Zr [21] is one of them. Second, modification the surface of conventional Mg alloys via bioactive coatings including hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) [22][23][24], Si [25,26], calcium-phosphorus [27], TiO 2 [28], bonelike apatite [29] and brushite [6].…”