Additive manufacturing with steel offers new opportunities for the construction sector. In particular, direct energy deposition (DED) processes such as Wire Arc Additive Manufacturing (WAAM or DED-Arc), are able to create large structures with a high degree of geometric freedom, like force-flow-optimized steel nodes and frameworks, as well as truss structures. By using high-strength steel, manufacturing times can be shortened because less material has to be applied. In order to enable the usage of WAAM components in the construction industry, profound knowledge of the material behavior is necessary. Based on reliable process parameters, extensive experimental and numerical investigations are carried out to characterize the influence of layer orientation and overhang angle on the mechanical parameters of WAAM high-strength low-alloy steel (HSLA) walls. The results have been compared to HSLA steel sheet material. It is shown that comparable characteristics exist for Young’s modulus E, yield strength Rp,0.2 and tensile strength Rm with regard to civil engineering applications. The influence of the loading direction on the material level is similar. Only the yield strength shows a slight dependence on the layer orientation for WAAM walls (difference 4.5%). The overhang angle has no influence on the material parameters.