Microvascular alterations in adult conscious spontaneously hypertensive rats.

Noble, Jos le; Smith, Thomas L.; Hutchins, Phillip M.; Struyker‐Boudier, H. A. J.

doi:10.1161/01.hyp.15.4.415

Cited by 29 publications

(11 citation statements)

References 20 publications

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“…Increased ratio of sympathetic to parasympathetic activity has already been proven in borderline hypertensives [43,44] and normotensives with an FHH [45,46]. Our results showed decreased HF power of the HRV spectrum in normotensives with an FHH, which speaks in favour of reduced vagal activity at the sinus node level.…”

Section: Discussionsupporting

confidence: 73%

Autonomic nervous system and microvascular alterations in normotensives with a family history of hypertension

2004

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Autonomic nervous system and microvascular alterations at pre-hypertensive stage of hypertension have still not been fully elucidated. We aimed at addressing central and local influences on microvascular reactivity at pre-hypertensive stage of hypertension. To that end, we studied microvascular reactivity in 59 normotensives with a family history of hypertension and 46 controls. We measured laser-Doppler flow on the finger nailfold skin in the resting condition, after an 8-min occlusion of digital arteries and during local nitroglycerin application. Finger pressure, pulse and ECG were monitored by a Finapres device. Heart rate power spectral analysis was performed using Fast Fourier transformation. Baroreflex sensitivity was estimated by the sequence method. Normotensives with a family history of hypertension showed higher systolic pressure, decreased high-frequency power of the heart rate variability spectrum and reduced baroreflex sensitivity in the resting condition as well as decreased fundamental frequency of laser-Doppler flow oscillations during nitroglycerin application. We conclude that normotensives with a family history of hypertension exhibit altered sympathovagal balance with decreased parasympathetic activity at the cardiac level as well as increased myogenic microvascular reactivity.

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Section: Discussionsupporting

confidence: 73%

Autonomic nervous system and microvascular alterations in normotensives with a family history of hypertension

2004

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“…It was proven even in borderline hypertensives [26,40] and in normotensives with a family history of hypertension [31,44]. Our results showed a decreased proportion and area of the high-frequency band of the heart rate variability power spectrum in normotensives with a family history of hypertension, which speaks in favor of increased sympathetic over vagal activity at the level of the sinus node.…”

Section: Discussionmentioning

confidence: 45%

Autonomic nervous system activity in normotensive subjects with a family history of hypertension

2004

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This study was designed to address alterations in autonomic nervous system activity in normotensive subjects with a family history of hypertension. We compared the autonomic nervous system activity in 59 normotensives with a family history of hypertension and 46 normotensives with no family history of hypertension. Skin blood flow was measured using laser-Doppler method on the nailfold skin in the resting condition, during systemic cooling and during upright tilting. Finger blood pressure, pulse and ECG were monitored by a finapres device. Heart rate, systolic pressure and microvascular flow power spectral analyses were performed using fast Fourier transformation. Baroreflex sensitivity was estimated with the sequence method. Compared to the control group, normotensives with a family history of hypertension showed significantly higher systolic pressure, decreased proportion and area of the high-frequency band of the heart rate variability power spectrum and reduced baroreflex sensitivity in the resting condition as well as a decreased proportion and area of the high-frequency band of the heart rate variability power spectrum during systemic cooling. We also proved a different time course of baroreflex sensitivity during upright tilting in the two groups. In contrast, we did not find any significant differences in the parameters of systolic pressure and microvascular variability power spectra between the two groups. Our results indicate that even normotensives with a family history of hypertension exhibit an increased ratio of sympathetic to parasympathetic activity at the cardiac level; however, they do not show any alteration of the vascular sympathetic reactivity.

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“…The technical details of the DMC in rats have been published elsewhere [28,29,361. The DMC consists of two halves made of polycarbonate.…”

Section: Dorsal Microcirculatory Chamber (Dmc)mentioning

confidence: 99%

Assessment of the Microcirculation in Cardiovascular Disease

et al. 1996

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Microvascular alterations in adult conscious spontaneously hypertensive rats.

Cited by 29 publications

References 20 publications

Autonomic nervous system and microvascular alterations in normotensives with a family history of hypertension

Autonomic nervous system and microvascular alterations in normotensives with a family history of hypertension

Autonomic nervous system activity in normotensive subjects with a family history of hypertension

Assessment of the Microcirculation in Cardiovascular Disease

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