Microvascular complications and their associated risk factors in type 2 diabetes mellitus

Khanam, Parvin Akter; Hoque, Sayama; Begum, Tanjima; Habib, Samira Humaira; Latif, Zafar Ahmed

doi:10.1016/j.dsx.2017.04.007

Cited by 31 publications

(31 citation statements)

References 9 publications

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“…Regarding the relationship between gender and incidence and severity of microvascular complications, severe complications were frequently reported in female subjects [22]. In concordant with literature, the incidence of microvascular complication in the current study population was two-times higher in female subjects as compared to the proportion in male subjects while adjusting for glycemic level and genetic predisposition.…”

Section: Major Microvascular Complications and Associated Factorssupporting

confidence: 78%

“…In the current study however, BMI has no univariate association with microvascular complications, and hence omitted from multivariate analysis. Regarding the relationship between diabetic duration and incidence and severity of microvascular complications, our result lacks literature support, as severe complications were frequently reported in patients with longer diabetic duration [9,22]. The root cause of this discrepancy needs further large prospective studies.…”

Section: Major Microvascular Complications and Associated Factorscontrasting

confidence: 39%

“…In addition, people with diabetes also suffer from developing infections. In almost all highincome countries, diabetes is a leading cause of blindness, kidney failure, and lower limb amputation [22,23,34]. In the current study, the overall prevalence of major microvascular complications (DPN, diabetic foot ulcer, visual disturbance, and skin and subcutaneous infections) was 41.5%; the proportion which is comparable with 52.9% prevalence report from Waktola et.al [26], but much higher than the prevalence reported from other studies [9,10].…”

Section: Major Microvascular Complications and Associated Factorsmentioning

confidence: 99%

“…Besides, HbA1 C is becoming a screening tool of patients at increased risk of chronic diabetic complications [22,23]. Considering the benefits of HbA1 C assay, several international bodies such as American Diabetes Association [24] and WHO [25] recommend HbA1 C test at least twice yearly.…”

Section: Introductionmentioning

confidence: 99%

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Major Micro vascular Complications and Associated Risk Factors among Diabetic Outpatients in Southwest Ethiopia

AN¹,

Waktola²,

GM³

et al. 2017

Endocrinol Metab Syndr

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Background: Diabetic complications and comorbidities, mainly due to poorly controlled diabetes, are the common causes of hospital admissions and mortalities among diabetic populations. Although studies from Ethiopia show high incidence of complications, data on associated risk factors is scarce. The current study was aimed to assess the potential risk factors contributing to microvascular diabetic complications in the study area.

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Section: Major Microvascular Complications and Associated Factorssupporting

confidence: 78%

Section: Major Microvascular Complications and Associated Factorscontrasting

confidence: 39%

Section: Major Microvascular Complications and Associated Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Major Micro vascular Complications and Associated Risk Factors among Diabetic Outpatients in Southwest Ethiopia

AN¹,

Waktola²,

GM³

et al. 2017

Endocrinol Metab Syndr

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show abstract

“…Согласно данным проведенных исследований, среди важнейших факторов, сопряженных с развитием микрососудистых нарушений при СД2, рассматриваются возраст больного [18][19][20], повышенные показатели системного артериального давления, значения HbA 1c , глюкозы натощак (FBG) и через 2 ч после завтрака (2 hBG) [21,22], а также индекса массы тела, включая антропометрические показатели ожирения, такие как окружность талии (WC), соотношение талии к бедрам (WHR) и талии к росту (WHtR) [23]. Ряд исследователей [10] особо выделяют дислипидемию, артериальную гипертонию и курение как наиболее значимые факторы риска развития ДПН.…”

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The efficacy of cocarnit in diabetic neuropathy

Котов¹,

Исакова²,

Leidvoll³

et al. 2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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The positive dynamics based on the VAS (р=0.0001), TSS (р=0.0001), NSS (р=0.001), NDS (р=0.0431), SF-36 (р=0.0008), electroneuromyographic results and glycated hemoglobin levels was observed in the main group. In patients of the comparison group, the positive dynamics was instable; the scores of clinical scales did not reach statistical significance. The results suggest the use of cocarnit in the complex treatment of patients with diabetic neuropathy.

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Superficial Femoral Artery Calcification Is a Novel Risk Factor of Microvascular Complications in T2DM Patients

Tian

Gao

et al. 2020

Calcif Tissue Int

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Microvascular complications are prevalent in patients with type 2 diabetes mellitus (T2DM), resulting in increased risk of cardiovascular mortality. However, it is unclear whether above-knee artery calcification relates to microvascular complications. This study was aimed to investigate the role of calcification in superficial femoral arteries (SFA), the major above-knee artery, compared with anterior tibial arteries (ATA) and posterior tibial arteries (PTA), in T2DM-related microvascular complications and explore its risk factors. A single-center and observational study involving 359 T2DM patients was conducted. Clinical and laboratory data were collected. SFA calcification was evaluated by ultrasonography. Compared with ATA and PTA calcification, operating characteristics curve analysis showed that SFA calcification was the strongest predictor (63.1% sensitivity and 69.2% specificity) for T2DM-related microvascular complications (diabetic neuropathy, diabetic nephropathy and diabetic retinopathy). With the severity of SFA calcification increased, age, duration of T2DM, and SBP were significantly elevated, but triglyceride and glucose index and estimated glomerular filtration rate (eGFR) were significantly reduced (all P < 0.05). Multivariate logistic analysis showed that eGFR (OR 0.953; 95% CI 0.931-0.976; P < 0.001) was an independent risk factor of SFA calcification, especially in young patients with HbA1c > 7.0. We identified SFA calcification as a good predictor of microvascular complications in T2DM patients. Reduced eGFR was significantly associated with increased SFA calcification prevalence, especially in young T2DM patients with bad controlled hyperglycemia. Keywords Type 2 diabetes mellitus • Superficial femoral artery calcification • Microvascular complications • Estimated glomerular filtration rate • Hyperglycemia Abbreviations ATA Anterior tibial arteries BMI Body mass index * Xiaolin Xu

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Microvascular complications and their associated risk factors in type 2 diabetes mellitus

Cited by 31 publications

References 9 publications

Major Micro vascular Complications and Associated Risk Factors among Diabetic Outpatients in Southwest Ethiopia

Major Micro vascular Complications and Associated Risk Factors among Diabetic Outpatients in Southwest Ethiopia

The efficacy of cocarnit in diabetic neuropathy

Superficial Femoral Artery Calcification Is a Novel Risk Factor of Microvascular Complications in T2DM Patients

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