Microwave-assisted extraction and high-speed counter-current chromatography purification of ferulic acid from Radix Angelicae sinensis

Liu, Zhilan; Wang, Juan; Shen, Pingniang; Cheng-yun, Wang; Shen, Yongjia

doi:10.1016/j.seppur.2006.03.009

Cited by 52 publications

(16 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HSCCC eliminates the irreversible adsorptive loss of samples onto the solid support matrix as used in the conventional chromatographic column [14]. This method has been successfully applied to the analysis and separation of various natural products [15][16][17][18]. However, no report has been published on the use of SFE to extract and HSCCC to isolate eugenol from natural plants.…”

Section: Introductionmentioning

confidence: 99%

An efficient method for extraction, separation and purification of eugenol from Eugenia caryophyllata by supercritical fluid extraction and high-speed counter-current chromatography

Geng

Liu

et al. 2007

Separation and Purification Technology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

An efficient method for extraction, separation and purification of eugenol from Eugenia caryophyllata by supercritical fluid extraction and high-speed counter-current chromatography

Geng

Liu

et al. 2007

Separation and Purification Technology

View full text Add to dashboard Cite

“…Corncob exhibited the best ferulic acid yield, where 396 µM accumulated in the culture broth. However, FA with purity greater than 98% was obtained from extracts of Radix Angelicae sinensis after microwave-assisted extraction (MAE) followed by highspeed counter-current chromatography (HSCCC) (Liu et al, 2006). …”

mentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

View full text Add to dashboard Cite

Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

show abstract

“…However, these conventional methods are consumed longer extraction time, large quantities of organic solvents, and often offered low recoveries of the target products. Microwave-assisted extraction (MAE), an improved method with good extraction efficiency and environmental-friendliness, has been successfully used for the effective separation of various natural products such as quercetin from Anoectochilu roxburghii [17], isofraxidin from Sarcandra glabra [18], bergenin from Ardisia crenata [19], ferulic acid from Angelicae sinensis [20], and dehydrocavidine from Corydalis saxicola [21]. High-speed counter-current chromatography (HSCCC), being as a kind of liquid-liquid partition chromatography, eliminates irreversible adsorption of samples on solid support in conventional column chromatography and offers excellent recovery of target compounds.…”

Section: Introductionmentioning

confidence: 99%

Combined microwave-assisted extraction and high-speed counter-current chromatography for separation and purification of xanthones from Garcinia mangostana

Fang

Liu

Zhuang

et al. 2011

Journal of Chromatography B

View full text Add to dashboard Cite

Microwave-assisted extraction and high-speed counter-current chromatography purification of ferulic acid from Radix Angelicae sinensis

Cited by 52 publications

References 8 publications

An efficient method for extraction, separation and purification of eugenol from Eugenia caryophyllata by supercritical fluid extraction and high-speed counter-current chromatography

An efficient method for extraction, separation and purification of eugenol from Eugenia caryophyllata by supercritical fluid extraction and high-speed counter-current chromatography

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Combined microwave-assisted extraction and high-speed counter-current chromatography for separation and purification of xanthones from Garcinia mangostana

Contact Info

Product

Resources

About