Microwave-assisted synthesis of biologically active amide derivatives of naphthenic acids under neat conditions

Abstract

Within the field of green chemistry, a noticeable results were obtained in the solvent-free synthesis of amide derivatives of naphthenic acids under microwave irradiation. Naphthenic acid amides, anilides, and morpholides were synthesized directly from free carboxylic acids and amines in the absence of solvent and catalyst under high-temperature heating in a closed-vessel system of microwave reactor. With this new and efficient method, different primary, secondary, and tertiary amide derivatives of naphthenic acids were obtained in good to excellent yields. Synthesized derivatives were assayed as plant rooting agents for their stimulative effects on the formation of adventitious roots in sunflower cuttings and susceptibility for growth stimulation of Pseudomonas sp. strains.

Macrocyclic sulfone derivatives: Synthesis, characterization, in vitro biological evaluation and molecular docking

“…Biological studies on the recently synthesized sulfones have revealed their antifungal (Xu et al, 2011), antiparasitic (Kerr et al, 2009), antimicrobial (Patil et al, 2010), antiviral (La Regina et al, 2007), antimalarial (Bader et al, 1969), antileprotic (Dhar, 1975), insecticidal, ascarcidal, analgesic, and hypnotic (Buehler & Masters, 1939) activities. Similarly, amide group owes its importance due to its presence in many synthetic intermediates, biomolecules and active pharmaceutical products (Grbovi c et al, 2018). It is noteworthy that combining the two groups into the same molecule might render important biological properties to the molecule.…”

Synthesis of chiral tripodal receptors under solvent-free conditions using microwave irradiation for investigation of anion and cation recognition properties

“…Otherwise, conversion of carboxylic acids to more reactive intermediates would be necessary to obtain amides. [24][25][26][27][28][29][30] Herein, we report the synthesis of a series of novel chiral tripodal receptors based on the formation of amide bonds under microwave irradiation, and an evaluation of their molecular recognition abilities towards a wide range of anions (H 2 PO 4 -, HSO 4…”