Microwave-assisted synthesis of novel 8-chloro-[1,2,4]triazolo[4,3-$a$]pyridine derivatives

Abstract

A series of novel 1,2,4-triazolo[4,3-a ]pyridine derivatives were synthesized from 2,3-dichloropyridine and hydrazine hydrate as starting materials by multistep reactions under microwave assistance, and their structures were characterized by 1 H NMR, MS, and elemental analysis. This method provides several advantages such as high yields, facile work-up, and environmental friendliness.

Synthesis and insecticidal activity of novel pyrimidine derivatives containing urea pharmacophore against Aedes aegypti

“…Microwave technology was applied to the synthetic reaction to shorten the reaction time and increase the yields of urea derivatives 4 . The key intermediate 2‐{[2‐(diethylamino)‐6‐methylpyrimidin‐4‐yl]oxy}acetohydrazide 3 and the substituted isocyanatobenzenes were synthesized according to our previous work . The reaction mechanism is a nucleophile substitution reaction.…”

Synthesis, nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives

“…For example, penthiopyrad is one of new succinate dehydrogenase inhibitors which can inhibit Colletotrichum, invented by Mitsui Chemicals Co. Ltd. On the other hand, pyridine derivatives also displayed diversity activities. [9][10][11][12][13] Chlorantraniliprole, discovered by DuPont, is a novel class of insecticide which target insect ryanodine receptors (RyR) and commercialized in 2008.…”

Synthesis and Nematocidal Activity of N‐Substituted 3‐Methyl‐1H‐pyrazole‐4‐carboxamide Derivatives Against Meloidogyne incognita

“…In line with our continued efforts in the synthesis of novel lead compounds for pesticide , the commercial carboxamide fungicide penflufen was selected as a lead compound. The scaffold of the lead compound is maintained at the 1‐methyl‐3‐methyl‐1 H ‐pyrazole‐4‐carboxamide section.…”