Microwave radiation can increase the rate of enzyme-catalysed reactions in organic media

Parker, Marie Claire; Besson, Thierry; Lamare, Sylvain; Legoy, Marie‐Dominique

doi:10.1016/0040-4039(96)01544-4

Cited by 94 publications

(43 citation statements)

References 15 publications

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“…The study of microwave action on biological systems is an area of intense interest. 21 A major drawback for applying lipase-catalyzed reactions in organic synthesis is lower reaction rates. Synergism with microwave is known to enhance the rate of lipase-catalyzed reaction.…”

Section: Introductionmentioning

confidence: 99%

Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid

Yadav

Sajgure

2007

J of Chemical Tech & Biotech

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Isoniazid is a useful antitubercular drug widely employed in combination therapy with rifampicin. The synthesis of isoniazid from ethyl isonicotinate and hydrazine hydrate was studied in non-aqueous media via lipase-catalyzed hydrazinolysis under both conventional heating and microwave irradiation by using different supported lipases. Among three different commercial lipases used, namely Novozym 435 (Candida antarctica lipase), Lipozyme RM IM (Rhizomucor miehei lipase) and Lipozyme TL IM (Thermomyces lanuginosus lipase), Novozym 435 was found to be the most effective, with conversion of 54% for equimolar concentrations at 50• C in 4 h. The rate of reaction as well as final conversion increased synergistically under microwave irradiation in comparison with conventional heating, which showed 36.4% conversion, even after 24 h, for the control experiment. Effects of various process parameters such as speed of agitation, catalyst loading, substrate concentration, product concentration and temperature were studied. A kinetic model is also described.

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Section: Introductionmentioning

confidence: 99%

Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid

Yadav

Sajgure

2007

J of Chemical Tech & Biotech

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“…Microwave irradiation has an effect on enzyme activity as a function of enzyme hydration. 35 This results from material-wave interactions leading to thermal effects (connected to dipolar and charge space polarization) and specific (purely nonthermal) effects. 36 The thermal gradients and flow of heat is the reverse of those in materials heated by conventional means.…”

Section: Introductionmentioning

confidence: 99%

Insight into microwave irradiation and enzyme catalysis in enantioselective resolution of RS‐( ± )‐methyl mandelate

Yadav

Sajgure

Dhoot

2008

J of Chemical Tech & Biotech

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BACKGROUND: Mandelic acid enantiomers are important chiral analogs used for the resolution of racemic alcohols and amines. R-(−)-mandelic acid is a precursor for the production of semi-synthetic penicillins and cephalosporins and also for the synthesis of various pharmaceuticals. Production of optically pure mandelic acid enantiomers is commercially significant. This work deals with the resolution of RS-(±)-methyl mandelate to produce optically pure R-(−)-mandelic acid in non-aqueous media via lipase-catalyzed hydrolysis under microwave irradiation.

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“…Parker et al [31] studied a transesterification reaction catalysed by a cutinase, in liquid medium, without solvent addition (Scheme 2). Thermodynamic water activities (a w ) of substrates and enzyme powder were equilibrated at a fixed value, before the reaction.…”

Section: Enzymatic Activity Under Microwave Irradiationmentioning

confidence: 99%

Influence of microwave irradiation on enzymatic properties: applications in enzyme chemistry

Rejasse

Lamare

Legoy

et al. 2007

Journal of Enzyme Inhibition and Medicinal Chemistry

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Although microwave-assisted reactions are widely applied in various domains of organic chemistry, their use in the area of enzyme chemistry has been rather limited, due to the high temperatures associated with the microwave heating: Because current technology, allows a good control of reaction parameters, several examples of microwave-assisted enzyme chemistry have been reported, using stable and effective biocatalysts (modified enzymes). The purpose of this review is to highlight the applications and studies on the influence of microwave irradiation on enzymatic properties and their application in enzyme chemistry.

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Microwave radiation can increase the rate of enzyme-catalysed reactions in organic media

Cited by 94 publications

References 15 publications

Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid

Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid

Insight into microwave irradiation and enzyme catalysis in enantioselective resolution of RS‐( ± )‐methyl mandelate

Influence of microwave irradiation on enzymatic properties: applications in enzyme chemistry

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