Mid-esophageal Ulceration and Candidiasis-associated Distal Esophagitis as Two Distinct Clinical Patterns of Tetracycline or Doxycycline-induced Esophageal Injury

Gençosmanoğlu, Rasim; Kurtkaya-Yapıcıer, Özlem; Tıftıkcı, Arzu; Avşar, Erol; Tözün, Nurdan; Oran, Ebru

doi:10.1097/01.mcg.0000129058.69524.90

Cited by 29 publications

(17 citation statements)

References 23 publications

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“…Despite the absence of strictures, dysphagia was the commonest in our case series which is similar to the findings in Saudi Arabia [4]. Symptoms typically get better within a few days of discontinuing doxycycline as was seen in our cases but protracted courses up to six weeks have been reported [5].…”

Section: Discussionsupporting

confidence: 73%

Oesophageal injury suspected to be due to doxycycline ingestion

Fernandopulle¹,

Navarathne

2011

Ceylon Med. J.

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Doxycycline induced oesophageal injury (DIEI) has contributed to 27% of the global burden of drug induced oesophageal injury. We report 21 cases of DIEI detected over a one year period.Cases were defined as sudden onset -chest pain, dysphagia and odynophagia within a few hours to days after taking doxycycline, confirmed by UGIE, with improvement on withdrawal of doxycycline. The majority was in the 20 -30 year age group and was female. The commonest symptoms were dysphagia and odynophagia. The mean time to symptoms from ingestion of doxycycline was 2.5 days. Majority of ulcers were in the mid oesophagus. Our case series highlights a preventable adverse drug reaction, which may have been avoided by giving simple advice to the patient.

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Section: Discussionsupporting

confidence: 73%

Oesophageal injury suspected to be due to doxycycline ingestion

Fernandopulle¹,

Navarathne

2011

Ceylon Med. J.

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“…Previous studies showed carvacrol as a potent and cost-effective agent against periodontal pathogens providing an adjunct mechanism that inhibits periodontal pocket formation (Osakawa et al, 1990;Botelho et al, in press). The local administration of carvacrol minimizes gastrointestinal side effects usually associated with longterm tetracycline administration (Gencosmanoglu et al, 2004). The use of locally delivered gel, such as carvacrol gel is an important adjunct for the treatment of periodontal disease drugs (Machion et al, 2006); In the present study, a significant (P < 0.05) decrease in the alveolar bone loss in the CAG group was observed as compared to vehicle-treated rats (Fig.…”

Section: Discussionsupporting

confidence: 53%

Protective effect of locally applied carvacrol gel on ligature‐induced periodontitis in rats: a tapping mode AFM study

Botelho

Martins

Ruela³

et al. 2009

Phytotherapy Research

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The aims of this study were to test a locally applied carvacrol gel and determine its efficacy preventing alveolar bone loss in experimental periodontitis in rats by regular methodology to validate applicability the atomic force microscopy (AFM) as a novel morphology method on this model. Wistar rats were subjected to ligature around second, upper-left molars. Animals were treated carvacrol gel topically (CAG), immediately after Experimental Periodontitis Disease induction for 1' three-times/day for 11 days. A vehicle gel was utilized as control. The periodontium and the surrounding gingivae were examined at regular histopathology and by AFM method; the neutrophil influx into the gingivae was also assayed using myeloperoxidase activity. The bacterial flora was assessed through culture of the gingival tissue. Alveolar bone loss was significantly inhibited by CAG group compared to the Vehicle (V) group, the carvacrol gel treatment reduced tissue lesion at histopathology, with preservation of the periodontium, coupled to decreased myeloperoxidase activity in gingival tissue and also prevented the proliferation of periodontal microorganisms and the weight loss. The GAC treatment preserved alveolar bone resorption and showed anti-inflammatory and antibacterial activities in experimental periodontitis. Topographical changes in histological sections were seen bringing into high relief the periodontal structures, being a simple and cost-effective method for periodontal evaluation with ultrastructural resolution.

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“…Common reason of this complication has been taking medications just before bedtime, and with a small amount of water [ 1 , 2 ]. In general the certain drugs tend to cause the damage in a singular segment, as doxycycline in mid-esophageal segment [ 3 ]. Here we present a severe, unusual endoscopic appearance of a case of doxycycline-induced esophageal ulcers and tissue fragility mimicking esophageal cancer in the lower and mid-esophageal segments, simultaneously.…”

Section: Introductionmentioning

confidence: 99%