Mid-term results of a new femoral prosthesis using Ti-Nb-Sn alloy with low Young’s modulus

Chiba, Daisuke; Yamada, Norikazu; Mori, Yu; Oyama, Masamizu; Ohtsu, Susumu; Kuwahara, Yoshiyuki; Baba, Kazuyoshi; Tanaka, Haruko; Aizawa, Tadanori; Hanada, Shuji; Itoi, Eiji

doi:10.1186/s12891-021-04879-1

Cited by 22 publications

(22 citation statements)

References 40 publications

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“…β-structured TiNbSn alloy increases its stiffness and Young’s modulus when the alloy is annealed at temperatures above 673 K ( Hanada et al, 2014 ). The results of a clinical trial of a TiNbSn alloy hip prosthesis have been reported, showing that the TiNbSn alloy hip prosthesis was effective in deterring thigh pain and bone atrophy due to stress shielding 3 years after surgery ( Chiba et al, 2021 ). Previous reports have also described that tibial fracture healing in mice and rabbits was enhanced using intramedullary nails made with TiNbSn alloy in comparison to using Ti6Al4V alloy and stainless steel ( Fujisawa et al, 2018 ; Kogure et al, 2019 ; Mori et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Kurishima

Mori

Inoue

et al. 2022

Front. Bioeng. Biotechnol.

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In this study, we anodized a TiNbSn alloy with low Young’s modulus in an electrolyte of sodium tartrate with and without hydrogen peroxide (H2O2). The photo-induced characteristics of the anodized alloy were analyzed for crystallinity and electrochemical conditions with comparisons to the effect with the addition of H2O2. The antibacterial activity was evaluated using methicillin-resistant Staphylococcus aureus and other pathogenic bacteria according to ISO 27447, and time decay antibacterial tests were also conducted. The anodized oxide had a porous microstructure with anatase- and rutile-structured titanium dioxide (TiO2). In contrast, the peaks of rutile-structured TiO2 were accelerated in the anodized TiNbSn alloy with H2O2. The formation of hydroxyl radicals and methylene blue breaching performance under ultraviolet irradiation was confirmed in the anodic oxide on TiNbSn alloy with and without H2O2. The anodic oxide on TiNbSn alloy had a robust antibacterial activity, and no significant difference was detected with or without H2O2. We conclude that anodized TiNbSn alloy with sodium tartrate electrolyte may be a functional biomaterial with a low Young’s modulus and an antibacterial function.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Kurishima

Mori

Inoue

et al. 2022

Front. Bioeng. Biotechnol.

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“…The Japanese Orthopedic Association (JOA) hip score [ 14 ] was used to evaluate hip joint function preoperatively and at the final observation. The JOA hip score was assessed by 40 points for pain, 20 points for range of motion, 20 points for gait, and 20 points for activities of daily living, for a total of 100 points.…”

Section: Methodsmentioning

confidence: 99%

Total hip arthroplasty after rotational acetabular osteotomy for developmental dysplasia of the hip: a retrospective observational study

Iwata

Shimamura

Senda

et al. 2022

BMC Musculoskelet Disord

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Background Total hip arthroplasty after osteotomy is more technically challenging than primary total hip arthroplasty, especially concerning cup placement. This is attributed to bone morphological abnormalities caused by acetabular bone loss and osteophyte formation. This study aimed to investigate the clinical and radiological outcomes of total hip arthroplasty after rotational acetabular osteotomy compared with those of primary total hip arthroplasty, focusing mainly on acetabular deformity and cup position. Methods The study included 22 hips that had undergone rotational acetabular osteotomy and 22 hips in an age- and sex-matched control group of patients who underwent total hip arthroplasties between 2005 and 2020. We analyzed cup abduction and anteversion; lateral, anterior, and posterior cup center–edge angle; hip joint center position; femoral anteversion angle; and presence of acetabular defect using postoperative radiography and computed tomography. Operative results and clinical evaluations were also analyzed. Results The clinical evaluation showed that the postoperative flexion range of motion was lower in total hip arthroplasty after rotational acetabular osteotomy than in primary total hip arthroplasty, although no significant difference was noted in the postoperative total Japanese Orthopedic Association hip score. The operative time was significantly longer in the rotational acetabular osteotomy group than in the control group, but there was no significant difference in blood loss. The lateral cup center–edge angle was significantly higher and the posterior cup center–edge angle was significantly lower in the total hip arthroplasty after rotational acetabular osteotomy, suggesting a posterior bone defect existed in the acetabulum. In total hip arthroplasty after rotational acetabular osteotomy, the hip joint center was located significantly superior and lateral to the primary total hip arthroplasty. Conclusions In total hip arthroplasty after rotational acetabular osteotomy, the cup tended to be placed in the superior and lateral positions, where there was more bone volume. The deformity of the acetabulum and the high hip center should be considered for treatment success because they may cause cup instability, limited range of motion, and impingement.

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“…Among the new high-performance titanium alloys, TiNbSn alloys, which combine low Young’s modulus with high strength, have already achieved clinical applications. The mid-term results of a clinical trial of a TiNbSn alloy hip prosthesis are reported, with good results in terms of the safety and suppression of stress shielding [ 17 ]. In contrast, there are still issues to be resolved to achieve consistent anodizing on large-scale orthopedic prostheses.…”

Section: Future Research Developmentmentioning

confidence: 99%

“…TiNbSn alloy stems with high proximal strength and low Young’s modulus in the distal part are considered ideal for fatigue fracture prevention and stress shielding. In the mid-term results of clinical trials of TiNbSn alloy stems, stress shielding was reported to be suppressed [ 17 ] ( Figure 1 ). The 3-year post-operative results of the TiNbSn stem clinical trial showed only minor stress shielding of grade 2 or less on Engh’s classification of stress shielding [ 10 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the mid-term results of clinical trials of TiNbSn alloy stems, stress shielding was reported to be suppressed [ 17 ] ( Figure 1 ). The 3-year post-operative results of the TiNbSn stem clinical trial showed only minor stress shielding of grade 2 or less on Engh’s classification of stress shielding [ 10 , 17 ]. This is the first report of clinical trial results of a low Young’s modulus titanium alloy hip prosthesis, and TiNbSn alloy is a high-performance material that can be clinically applied as an orthopedic implant.…”

Section: Introductionmentioning

confidence: 99%

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A Review of Anodized TiNbSn Alloys for Improvement in Layer Quality and Application to Orthopedic Implants

2022

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Titanium alloys are useful for application in orthopedic implants. However, complications, such as prosthetic infections and aseptic loosening, often occur after orthopedic devices are implanted. Therefore, innovation in surface modification techniques is essential to develop orthopedic materials with optimal properties at the biomaterial–bone interface. In this review, we present recent research on the improvement in the osteoconductivity and antibacterial effect of the Ti-33.6% Nb-4% Sn (TiNbSn) alloy by anodic oxidation and other related studies. TiNbSn alloys are excellent new titanium alloys with a low Young’s modulus, high tensile strength, and with gradient functional properties such as a thermally adjustable Young’s modulus and strength. Titanium dioxide (TiO2), when obtained by the anodic oxidation of a TiNbSn alloy, improves bone affinity and provides antibacterial performance owing to its photocatalytic activity. The safety of TiO2 and its strong bonding with metal materials make its method of preparation a promising alternative to conventional methods for improving the surface quality of orthopedic implants. Implementing anodization technology for TiNbSn alloys may alleviate orthopedic surgery-related complications, such as loosening, stress shielding, and infection after arthroplasty.

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Mid-term results of a new femoral prosthesis using Ti-Nb-Sn alloy with low Young’s modulus

Cited by 22 publications

References 40 publications

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Total hip arthroplasty after rotational acetabular osteotomy for developmental dysplasia of the hip: a retrospective observational study

A Review of Anodized TiNbSn Alloys for Improvement in Layer Quality and Application to Orthopedic Implants

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