Mifepristone and misoprostol for early medical abortion: 18 months experience in the United States

Hausknecht, Richard

doi:10.1016/s0010-7824(03)00049-0

Cited by 60 publications

(22 citation statements)

References 11 publications

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“…Other workers have also found that bleeding by medical abortion is not very different from that of bleeding by vacuum aspiration [3]. In our study, no patient had bleeding heavy enough to require blood transfusion, but in a study of 80,000 patients over 18 months, 13 patients required blood transfusion [10]. In the same study, the pregnancy continued in 0.06% cases and in 0.05% cases vacuum aspiration was required for incomplete abortion.…”

Section: Discussionsupporting

confidence: 51%

Medical Abortion-An Alternative to Surgical Abortion

Kapur

Joneja

Biswas

2006

Medical Journal Armed Forces India

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Background: Termination of early pregnancy has traditionally been done surgically, but agents are now available which can terminate pregnancy if taken orally, vaginally or parenterally. We have used a combination of mifepristone and misoprostol for termination of early pregnancy. Material and Method: Fifty patients having amenorrhoea of upto 56 days with confirmed intrauterine pregnancy, were selected for medical termination of pregnancy. The patients were given tablet mifepristone (200mg) on day 1 and tablet misoprostol (400mcg) on day 3. On day 14, an ultrasound was done to confirm complete abortion. Result: Majority 35 (70%) patients had amenorrhoea between 40 -50 days. The duration of bleeding was less than 5 days in 12%, between 5 -10 days in 56%, 10 -13 days in 16% and greater than 14 days in 16%. In all patients with bleeding of more than 14 days ultrasonography confirmed intrauterine products & a suction evacuation was done. In this series there were no failures. Conclusion : The combination of mifepristone and misoprostol is an effective method for termination of early pregnancy up to 56 days of amenorrhoea.

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Section: Discussionsupporting

confidence: 51%

Medical Abortion-An Alternative to Surgical Abortion

Kapur

Joneja

Biswas

2006

Medical Journal Armed Forces India

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“…9,11,13 In a study of Hausknecht 80,000 patients over 18 months, 13patients needed blood transfusion that is 0.01%, when the drugs were given under medical super vision. 15 In a study by Deshpande S et al, no women required blood transfusion when drugs were given under medical supervision. 16 Haemorhage requiring blood transfusions occur in only about 1 in 1000 cases when drugs are given under medical supervision.…”

Section: -13mentioning

confidence: 98%

Mortality and morbidity associated with illegal use of abortion pill: a prospective study in tertiary care center

et al. 2016

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“…52 % had received one-unit transfusion, whereas 23 % required transfusion of more than one unit. In a study of 80,000 patients [13] over 18 months, only 0.01 % patients required blood transfusion when the drugs were given under medical supervision. In a study by Deshpande et al [14], no women required a blood transfusion when drugs are given under medical supervision.…”

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confidence: 99%

Over-the-counter MTP Pills and Its Impact on Women’s Health

Sarojini

Ashakiran

Bhanu

et al. 2016

J Obstet Gynecol India

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Objectives To study the complications and consequences including maternal morbidity and mortality following indiscriminate self-consumption of abortion pills reporting to a tertiary care center. Methodology This is an observational study conducted at Vanivilas hospital between January 2012 to December 2013 for 24 months. After applying inclusion and exclusion criteria, 104 women were studied with respect to period of gestation, parity, clinical features at presentation and management in the institution. An analysis of maternal morbidity and mortality was done with respect to surgical interventions, ICU admissions, need for blood transfusions and maternal deaths. Observations and results In this study, there were 75 (72.2 %) cases of incomplete abortion, 10 (9.6 %) cases of missed abortion, 2 (1.9 %) cases of ruptured ectopic and 2 123(1.9 %) cases of rupture uterus. Seventy-eight (75 %) cases received blood transfusion, 7 (6.7 %) were admitted to ICU, and 2 (1.9 %) developed acute kidney injury. There were 2 (1.9 %) maternal deaths in the study group. Conclusion This study shows urgent need for legislation and restriction of drugs used for medical termination of pregnancy. Drugs should be made available via health care facilities under supervision to reduce maternal mortality and morbidity due to indiscriminate use of these pills.

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Mifepristone and misoprostol for early medical abortion: 18 months experience in the United States

Cited by 60 publications

References 11 publications

Medical Abortion-An Alternative to Surgical Abortion

Medical Abortion-An Alternative to Surgical Abortion

Mortality and morbidity associated with illegal use of abortion pill: a prospective study in tertiary care center

Over-the-counter MTP Pills and Its Impact on Women’s Health

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