Migraine and Antiphospholipid Antibodies

Tietjen, Gretchen E.

doi:10.1046/j.1468-2982.1992.1202069.x

Cited by 28 publications

(8 citation statements)

References 53 publications

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“…Similar results were observed by Silvestrini et al [24] and Henrich and Horwitz [16]. The pathophysiologic mechanism, however, remains unclear, but may include a decrease in blood flow [25], vascular spasm [26], inflammatory vascular process [24,27], cardiac embolism [28] and abnormal release of vasoactive substances including prostaglandins, noradrenergic and cholinergic transmitters, nitric oxide and histamines [29].…”

Section: Discussionsupporting

confidence: 70%

Migraine History and Migraine-Induced Stroke in the Dijon Stroke Registry

et al. 1999

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Two thousand three hundred and eighty-nine patients with first-ever stroke were registered in the population-based Dijon Stroke Registry over an 11-year period. There was a history of migraine in 49 cases (2%), with a majority of women (2.8% versus 1.1% men) with the following distribution: 27 cases among 1,380 large-artery cerebral infarctions (1.9%), 6 cases among 358 small-artery cerebral infarctions (1.6%), 6 cases among 412 cerebral infarctions due to cardiac embolism (1.4%), 7 cases among 191 cerebral hemorrhages (3.6%) and 3 cases among 47 subarachnoid hemorrhages (6.3%). The male/female ratio was 0.58 for the 49 strokes with a history of migraine versus 1.27 for the 2,340 strokes with no history of migraine. Twelve migraine-induced ischemic strokes occurred with an infarction of the posterior area of the brain in young patients. The annual incidence was 0.80/100,000/year (confidence interval, CI = 0.37–1.57) with a predominance of women (1.02/100,000/year, CI = 0.52–1.25; men: 0.57/100,000/year; CI = 0.28–1.04). We conclude that a history of migraine is more frequent in women, in particular in those with hemorrhagic strokes, and that the incidence of migraine-induced stroke in our population-based study is higher in women, although it remains low.

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Section: Discussionsupporting

confidence: 70%

Migraine History and Migraine-Induced Stroke in the Dijon Stroke Registry

et al. 1999

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“…This percentage is similar to what was found in the population studied by Avcin et al [9], whereas confirmed positivity in the medium-high titers was observed in 12% of our patients. All other published works only involved studies on ACA [8][9][10][11][12][13][14][15][16][17][18][19], while LAC was only mentioned in three older works that described the first case reports or selected neurological patients [7,8,19]. The tests for aPL were repeated over time in only three cases to confirm results [13,18,19] and included comparisons between patients and controls [10][11][12][13]15,17].…”

Section: Discussionmentioning

confidence: 99%

“…In the 1980s, Hughes and colleagues first described the antiphospholipid syndrome (APS) [5], and headache and migraine are currently included among the symptoms [6]. There are several studies that have looked for a correlation between migraine and antiphospholipid antibodies (aPL), but so far data on the prevalence of antiphospholipid antibodies and any possible relationship with migraine are conflicting and incomplete, with a prevalence ranging from 0% to 30% of patients [7][8][9][10][11][12][13][14][15][16][17][18][19]. Recent data drawn from the European Registry for APS revealed that the most frequent symptom in APS is headache, mostly classified as migraine with and without aura [20,21].…”

Section: Introductionmentioning

confidence: 99%

Migraineurs show a high prevalence of antiphospholipid antibodies

Cavestro

Micca

Molinari

et al. 2011

Journal of Thrombosis and Haemostasis

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Summary. Background: It has been observed that migraineurs show a higher risk of thrombosis and that the most frequent symptom reported by patients with antiphospholipid syndrome is headache, especially migraine. Objectives: The aim of our research was to evaluate the prevalence of antiphospholipid antibodies (aPL) in a random cohort of migraineurs. Patients/Methods: This analytic, comparative case study was performed to evaluate the prevalence of antiphospholipid antibodies by comparing a population of migraineurs with and without aura with sex-and age-matched controls. Both the diagnosis of migraine and the laboratory diagnosis of aPL positivity were made on the basis of the most recent international guidelines. Results: Between September 2008 and August 2009, we recruited 284 consecutive patients (225 women and 59 men, 203 without aura and 81 with aura) and 225 controls (174 women and 51 men). Positivity for at least one test for aPL (LAC, ACA IgG or antiß2GLP1 IgG) was detected and confirmed in 12% (n = 33) of patients and in 3% (n = 7) of controls (odds ratio, 4.08; confidence interval, 1.77-9:39; P = 0.0004). Two of the patients had triple positivity for aPL (LAC, ACA and antiß2GLP1) and one had double positivity (LAC and antiß2GLP1); none of the controls showed multiple positivity. Conclusions: Our data show that migraineurs have a significantly higher prevalence of antiphospholipid antibodies, and point towards the fact that the two conditions may be comorbid or even that migraine may be an early sign for identifying patients with aPL positivity.

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“…None had measures of antiphospholipid antibodies or detailed coagulation studies. Thus, these patients could be among the group with transient neurological deficits and headache associated with the antiphospholipid antibody syndrome (22), which may mimic migraine with aura. On the other hand, a study (23) of 777 women found no difference in the complications of pregnancy in women with migraine compared with 182 controls without migraine.…”

Section: Mcrioyn Iiscmentioning

confidence: 99%