Migraine and Genetic Polymorphisms: An Overview

Pizza, V.; Agresta, A.; Agresta, Antonio; Lamaida, E.; Lamaida, Norman; Infante, F.; Capasso, Anna

doi:10.2174/1874205x01206010065

Cited by 16 publications

(12 citation statements)

References 27 publications

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“…On the other hand, several genetic polymorphisms probably increase thrombotic disorders among the migraineurs; however, these putative genes are extremely different from those linked to IBS. For examples, migraine related candidate genes include factor V Leiden , factor V ( H1299R ), prothrombin ( G20210A ), factor XIII ( V34L ), β-fibrinoge n and lipoprotein receptor ( LRP1 ) etc, whereas IBS related candidate genes consist of serotonin transporter ( SLC6A4 ), norepinephrine transporter ( NET ), alpha-2A-adrenergic receptors ( ADRA2A ), interleukin-10 ( IL-10 ), G protein β3 subunit ( GNβ3 ) and sodium channel ( SCN5A ) etc 73,75,76. In fact, the potential functions of these genetic variants are controversial because they result in a small to moderate risk of developing migraine which means that migraine is a heterogeneous disorder.…”

Section: Pathogenesesmentioning

confidence: 99%

Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Chang¹,

Lu²

2013

J Neurogastroenterol Motil

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Irritable bowel syndrome (IBS) and migraine are distinct clinical disorders. Apart from the characteristics of chronic and recurrent pain in nature, these pain-related disorders apparently share many similarities. For example, IBS is female predominant with community prevalence about 5-10%, whereas that of migraine is 1-3% also showing female predominance. They are often associated with many somatic and psychiatric comorbidities in terms of fibromyaglia, chronic fatigue syndrome, interstitial cystitis, insomnia and depression etc., even the IBS subjects may have coexisted migraine with an estimated odds ratio of 2.66. They similarly reduce the quality of life of victims leading to the social, medical and economic burdens. Their pathogeneses have been somewhat addressed in relation to biopsychosocial dysfunction, heredity, genetic polymorphism, central/visceral hypersensitivity, somatic/cutaneous allodynia, neurolimbic pain network, gonadal hormones and abuses etc. Both disorders are diagnosed according to the symptomatically based criteria. Multidisciplinary managements such as receptor target new drugs, melantonin, antispasmodics, and psychological drugs and measures, complementary and alternatives etc. are recommended to treat them although the used agents may not be necessarily the same. Finally, the prognosis of IBS is pretty good, whereas that of migraine is less fair since suicide attempt and stroke are at risk. In conclusion, both distinct chronic pain disorders to share many similarities among various aspects probably suggest that they may locate within the same spectrum of a pain-centered disorder such as central sensitization syndromes. The true pathogenesis to involve these disorders remains to be clarified in the future.

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Section: Pathogenesesmentioning

confidence: 99%

Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Chang¹,

Lu²

2013

J Neurogastroenterol Motil

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“…There are several neurological, hormonal and vascular genes that are considered as key factors in the pathophysiology of migraine [5]. It has been proposed that endothelial dysfunction, which increases oxidative stress and promotes inflammatory processes, is involved in the pathogenesis of migraine [6]. In this respect, MTHFR C677T genetic polymorphisms may play a crucial role in vascular diseases [3].…”

Section: Discussionmentioning

confidence: 99%

“…There are two common MTHFR polymorphisms, namely, C677T and A1298C [3,4]. In MTHFR C677T and A1298C polymorphisms, a point mutation occurs, which leads to the replacement of alanine by valine, while glutamine is replaced by alanine, respectively, in [5,6]. Thus, the role of MTHFR C677T gene polymorphism in migraine susceptibility needs further evaluation.…”

Section: Introductionmentioning

confidence: 99%

Correlation between MTHFR Genotype Polymorphisms and Different Types of Migraine Headache in Iranian Patients: A Case Control Study

Mirfakhraie¹,

Jamebozorgi²,

Ramezani³

et al. 2017

J Neurol Neurosci

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Background: Migraine affects about 16% of the worldwide population. The pathogenesis of the disease consists of a combination of genetic and environmental factors. Given that, according to different polymorphism studies, ethnicity has a role in the gene diversity of migraine, this study was designed to determine the role of MTHFR C677T gene polymorphism in people from Tehran, Iran, who suffer from migraine headaches.

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“…Late studies focus on the role of migraine as potential risk of endothelial dysfunction [5][6][7][8][9], which may further affect the normal function of vascular endothelial cells. Because endothelial dysfunction always occure in a situation of an increased oxidative stress and pro-inflammatory reaction, this proposed as one of pathogenesis of migraine [10]. Allergic sensitity are also considered to be one cause of migraine, in theory, allergy offers many suggestive possibilities as an etiological agent in magraine, but further study still need to be done fo prove this [11], [12].…”

Section: Introductionmentioning

confidence: 99%

Chinese Herbal Medicine for Migraine: An Application of Text Mining

Wang¹,

Jiang²,

Zheng³

et al. 2013

IJFCC

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Migraine is one of the most chronic disableheadache diseases, and it effects 5% to 10% of adults. Patientscould not work effectively, or even keep a high quality of life.As a complex neuro-vascular disease, the pathology ofmigraine is still not fully understood. Many medical methodsare applied to release symptoms or prophylaxis of migraine,such as behavior therapy, pyschotherapy, acupuncture,massage, and drug therapy. In China, Chinese herbalmedicines (CHMs) are also used to treat migraine. Throughthe long history, and also in modern era, various CHMs areprescribed in different formulae. In clinical practice, aproportion of patients in China will not only take biomedicaldrugs, but also receive CHMs therapy or combinationaltheatment. This combination will broaden new field in themanagement of migraine. To explore some answer to whichCHMs are most prescibed in formulaes and basic traits ofthese CHMs, as well as biomedical drugs in combination withthese CHMs, we designed a study based on text miningtechnology for these three questions. In this study, we built adataset from the information downloaded in Sinomed database.With our novel text mining method, CHMs in this dataset werecounted, and some fundamental parameters of each CHM,such as cold/heat property, flavours, and channel tropism werealso recorded. Besides, biomedical drugs prescribed togetherwith CHM were also involved in statistic. Results showed thatChuan Xiong, Tian Ma, Dan Shen, Dang Gui and Xi Xin arethe top 5 CHMs used to cure migraine. Among all these CHMs,warm CHMs were most frequently used in the treatment ofmigraine, pungent was the most frenquent flavour, and liver,heart are the top 2 channels, both these two visceras wererelated to human psychoactivity in TCM theory, and furtherregulate the disease acitivity of migraine. Cinnarizine,flunarizine, nimodipine, and nitroglycerin were drugs mostcombined with CHM to cure migraine. These results indicatedthat text mining could be an effective method in exploring therules of CHMs prescription and the combination ofbiomedicine and CHMs in treatment of migraine

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Migraine and Genetic Polymorphisms: An Overview

Cited by 16 publications

References 27 publications

Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Correlation between MTHFR Genotype Polymorphisms and Different Types of Migraine Headache in Iranian Patients: A Case Control Study

Chinese Herbal Medicine for Migraine: An Application of Text Mining

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