Migration of bipolar subependymal cells, precursors of the granule cells of the rat olfactory bulb, with reference to the arrangement of the radial glial fibers.

Kawakami, Kiyoshi; Peng, Jun Yun; Kakuta, Sachiko; Murakami, Kunio; Kuroda, Minpei; Yokota, Shizuko; Hayakawa, Sadao; Kuge, Takashi; Asayama, Toru

doi:10.1679/aohc.53.219

Cited by 57 publications

(37 citation statements)

References 27 publications

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“…The long journey through these glial fibers explains the delayed arrival and settling of these neurons in the ventrolateral cortical areas (Bayer and Altman, 1991b;Bayer et al, 1991;Misson et al, 1991). Finally, although neurogenesis is largely completed in the ST by E19 -E21 (Sidman and Angevine, 1962;Angevine and McConnell, 1974;Smart and Sturrock, 1979;Bayer, 1984), portions of the subventricular zone still continue to be mitotically active, giving rise to cells that migrate to the olfactory bulb (Altman and Das, 1966;Kishi, 1987;Kishi et al, 1990;Luskin, 1993).…”

Section: Resultsmentioning

confidence: 99%

Dynamics of Cell Migration from the Lateral Ganglionic Eminence in the Rat

1996

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From previous developmental studies, it has been proposed that the neurons of the ventrolateral cortex, including the primary olfactory cortex, differentiate from progenitor cells in the lateral ganglionic eminence. The objective of the present study was to test this hypothesis. The cells first generated in the forebrain of the rat migrate to the surface of the telencephalic vesicle by embryonic day (E) 12. Using [3 H]thymidine, we found that most of these cells contributed to the formation of the deep layer III of the primary olfactory cortex. To study the migratory routes of these cells, we made localized injections of the carbocyanine fluorescent tracers DiI and DiA into various parts of the lateral ganglionic eminence in living embryos at E12-E14 and subsequently maintained the embryos in a culture device for 17-48 hr. After fixation, most migrating cells were located at the surface of the telencephalic vesicle, whereas others were seen coursing tangentially into the preplate. Injections made at E13 and in fixed tissue at E15 showed that migrating cells follow radial glial fibers extending from the ventricular zone of the lateral ganglionic eminence to the ventrolateral surface of the telencephalic vesicle. The spatial distribution of radial glial fibers was studied in Golgi preparations, and these observations provided further evidence of the existence of long glial fibers extending from the ventricular zone of the lateral ganglionic eminence to the ventrolateral cortex. We conclude that cells of the primary olfactory cortex derive from the lateral ganglionic eminence and that some early generated cells migrating from the lateral ganglionic eminence transgress the cortico-striatal boundary entering the preplate of the neocortical primordium.

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Section: Resultsmentioning

confidence: 99%

Dynamics of Cell Migration from the Lateral Ganglionic Eminence in the Rat

1996

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“…Our previous reports (KIsHI, 1987;KISHI et al, 1990) have described two phases of migration of immature granule cells in the olfactory bulb. The first phase is the rostralwards migration of postmitotic precursor granule cells in the subependymal layer.…”

Section: Discussionmentioning

confidence: 94%

“…Definitive explanations for these striking differences in the rate of migration of immature granule cells are not readily apparent, although one possible explanation is that immature granule cells have a leading process with an unusually large growth cone acting as a great motile force for migration (KISHI, 1987). Another explanation may be the abundance of extracellular spaces throughout their course of migration in the subependymal layer, which is similar to the condition of cultured cerebellar granule cells that show a migration-rate of 33±20 , u m/h (KISHI et al, 1990;EDMONDSON and HATTEN, 1987).…”

Section: Discussionmentioning

confidence: 96%

“…Our previous reports have described two phases of migration of immature granule cells in the rat olfactory bulb (KIsHI, 1987;KIsHI et al, 1990). The first phase is the rostralward migration of bipolar granule cells in the subependymal layer; these originate in the subependymal layer around the anterior horn of the lateral ventricle, migrate through the subependymal layer along the olfactory ventricle, and reach the center of the bulb.…”

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confidence: 99%

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Development of Granule Cells of the Rat Olfactory Bulb: An Autoradiographic and Electron Microscopic Study.

Yokota

Kakuta

Ishikawa

1993

Archives of Histology and Cytology

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“…This interest might be attributed to several independent factors. First, studies by Kishi (9) and Kishi and coworkers (10), later confirmed and extended by Luskin (11) and by Lois and Alvarez-Buylla (12), indicated that the rostral telencephalic SVZ is a source of olfactory interneurons rather than of glial cells (but see Ref. 9) in developing and adult animals.…”

Section: Introductionmentioning

confidence: 92%

Proliferation of differentiated glial cells in the brain stem

Barradas

Cavalcante

1998

Braz J Med Biol Res

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Classical studies of macroglial proliferation in muride rodents have provided conflicting evidence concerning the proliferating capabilities of oligodendrocytes and microglia. Furthermore, little information has been obtained in other mammalian orders and very little is known about glial cell proliferation and differentiation in the subclass Metatheria although valuable knowledge may be obtained from the protracted period of central nervous system maturation in these forms. Thus, we have studied the proliferative capacity of phenotypically identified brain stem oligodendrocytes by tritiated thymidine radioautography and have compared it with known features of oligodendroglial differentiation as well as with proliferation of microglia in the opossum Didelphis marsupialis. We have detected a previously undescribed ephemeral, regionally heterogeneous proliferation of oligodendrocytes expressing the actin-binding, ensheathment-related protein 2'3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), that is not necessarily related to the known regional and temporal heterogeneity of expression of CNPase in cell bodies. On the other hand, proliferation of microglia tagged by the binding of Griffonia simplicifolia B4 isolectin, which recognizes an alpha-D-galactosyl-bearing glycoprotein of the plasma membrane of macrophages/microglia, is known to be long lasting, showing no regional heterogeneity and being found amongst both ameboid and differentiated ramified cells, although at different rates. The functional significance of the proliferative behavior of these differentiated cells is unknown but may provide a lowgrade cell renewal in the normal brain and may be augmented under pathological conditions.

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Migration of bipolar subependymal cells, precursors of the granule cells of the rat olfactory bulb, with reference to the arrangement of the radial glial fibers.

Cited by 57 publications

References 27 publications

Dynamics of Cell Migration from the Lateral Ganglionic Eminence in the Rat

Dynamics of Cell Migration from the Lateral Ganglionic Eminence in the Rat

Development of Granule Cells of the Rat Olfactory Bulb: An Autoradiographic and Electron Microscopic Study.

Proliferation of differentiated glial cells in the brain stem

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