Migration of di‐(2‐ethylhexyl) phthalate from PVC child articles into saliva and saliva simulant

Abstract

A simple migration test and a more complicated simulation of children's sucking and biting was used to establish migration of DEHP from PVC child-use articles into saliva and compared to a mimic test. The static migration test of a film containing approximately 30% DEHP with saliva simulant gave the lowest values of DEHP; simple shaking increased the amounts of DEHP from 25 +/- 8 to 499 +/- 153 micrograms/g film. The more complicated arrangements to simulate sucking and biting are not so suitable for standard applications. When comparing the in vitro migration tests with the mimic test the factors were 25 and 29 for the static tests (3 and 6 hours) and 1.4 for the shaking test.

Aqueous leaching of di-2-ethylhexyl phthalate and “green” plasticizers from poly(vinyl chloride)

“…The GC analysis method was then used to test the leaching of several series of potential "green" plasticizers and to suggest favourable structural characteristics of the plasticizer to minimize leaching. The combination of gravimetric analysis of PVC and GC analysis of migration product has been previously used in the analysis of polyadipate-plasticized PVC in medical tubing (Wang and Storm, 2005), and GC analysis of DEHP has been previously used to investigate migration of the plasticizer from child articles into saliva (Steiner et. al., 1998).…”

Comparison of Diisononyl Phthalate Migration from Polyvinyl Chloride Products into Human Saliva in Vivo and into Saliva Simulant in Vitro.

“…The composition of the simulated saliva corresponded to the British Standard Specification for Safety Harnesses. 12) Glassware was heated 180°C, and then the compounds were molded into 1.0-mm-thick plates containing DINP 462 mg/g. The PVC toys included a pacifier, a teething ring (teether), a rattle, a ball, and a soft doll that contained 538, 389, 380, 255, and 160 mg/g DINP, respectively.…”

Molecular modelling of phthalates – PPARs interactions

“…Mono-ethylhexyl phthalate (MEHP) is the active metabolite of DEHP. Its widespread usage in medical and paramedical appliances as well as in food storage packaging has led to DEHP being present as an ubiquitous environmental contaminant [1,2]. Given its high production volume and common use, humans are exposed through ingestion, inhalation, dermal and medical devices.…”