Mikrobieller Abbau von Papaverin

Abstract

A bacterium growing on papaverine as sole carbon and nitrogen source was isolated by incubation of soil with papaverine. The bacterium could be identified as aNocardia strain by morphological and physiological tests. When growing on papaverine, this strain excretes metabolites into the medium. Based on the structure of the metabolites 1-9 a degradation pathway is proposed.

Draft Genome Sequence of a Papaverine-Degrading, Gram-positive Arthrobacter sp., Isolated from Soil Near Hohenheim, Germany

“…Using papaverine as a substrate, a soil bacterium was isolated in Hohenheim, Germany, in the late 1970s ( 1 ). Morphological and physiological tests identified this microorganism as Nocardia sp.…”

“…During cultivation on papaverine as the sole source of carbon and nitrogen, several substrate intermediates were found to be excreted into the medium. A partial degradation pathway for papaverine involving initial ring hydroxylation was proposed ( 1 , 2 ). Here, we present a draft genome sequence by shotgun sequencing to explore its enzymatic content for novel oxygenases capable of converting bulky aromatic substrates such as papaverine.…”