Mild Cognitive Impairment: Differential Atrophy in the Hippocampal Subfields

Hanseeuw, Bernard; Leemput, Koen Van; Kavec, Martin; Grandin, Cécile; Serón, Xavier; Ivanoiu, Adrian

doi:10.3174/ajnr.a2589

Cited by 102 publications

(105 citation statements)

References 16 publications

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“…CA2-3 had the largest volume, followed by subiculum, CA4-DG, presubiculum and CA1, while the hippocampal fissure was the smallest subfield (table 2), which is consistent with previous studies employing the same subfield segmentation procedure [45,46]. Mean annual percentage change was negative in all regions and significant (p < 0.05) volume decreases over time were found bilaterally for CA2-3, CA4-DG, the presubiculum, subiculum and hippocampal fissure, as well as in the left CA1 (table 2).…”

Section: Resultssupporting

confidence: 80%

“…A positive association between verbal associative recognition and the combined volume of CA3 and CA4-DG has been found in healthy older adults [69], and verbal recall has been shown to relate to volumes of the CA2-3, CA4-DG and subiculum in patients with amnestic mild cognitive impairment [46]. Moreover, preliminary findings in a mixed group of cognitively intact and impaired subjects indicate that verbal short-term memory is associated with CA3 and DG, while intermediate memory is associated with CA1 [70].…”

Section: Discussionmentioning

confidence: 99%

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Regional Hippocampal Volumes and Development Predict Learning and Memory

et al. 2014

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The hippocampus is an anatomically and functionally heterogeneous structure, but longitudinal studies of its regional development are scarce and it is not known whether protracted maturation of the hippocampus in adolescence is related to memory development. First, we investigated hippocampal subfield development using 170 longitudinally acquired brain magnetic resonance imaging scans from 85 participants aged 8-21 years. Hippocampal subfield volumes were estimated by the use of automated segmentation of 7 subfields, including the cornu ammonis (CA) sectors and the dentate gyrus (DG), while longitudinal subfield volumetric change was quantified using a nonlinear registration procedure. Second, associations between subfield volumes and change and verbal learning/memory across multiple retention intervals (5 min, 30 min and 1 week) were tested. It was hypothesized that short and intermediate memory would be more closely related to CA2-3/CA4-DG and extended, remote memory to CA1. Change rates were significantly different across hippocampal subfields, but nearly all subfields showed significant volume decreases over time throughout adolescence. Several subfield volumes were larger in the right hemisphere and in males, while for change rates there were no hemisphere or sex differences. Partly in support of the hypotheses, greater volume of CA1 and CA2-3 was related to recall and retention after an extended delay, while longitudinal reduction of CA2-3 and CA4-DG was related to learning. This suggests continued regional development of the hippocampus across adolescence and that volume and volume change in specific subfields differentially predict verbal learning and memory over different retention intervals, but future high-resolution studies are called for.

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Section: Resultssupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Regional Hippocampal Volumes and Development Predict Learning and Memory

et al. 2014

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“…We hypothesized that, relative to controls, patients classified as mdMCI would display greater atrophy in a wider range of selected HP subfields than aMCI. Specifically, we expected PRC and ERC atrophy, and CA2-3, subiculum and presubiculum subfield atrophy in both aMCI and mdMCI as these have previously been reported to be atrophic with similar HP segmentation approaches [19,20]. Furthermore, we expected a relatively more pronounced atrophy in the HP subfields, including total HP volume in the mdMCI subgroup as this group may represent a more advanced MCI stage than aMCI [37].…”

Section: Introductionmentioning

confidence: 99%

“…Inconsistent findings as to which HP region is affected in MCI across studies may be related to the variability in segmentation techniques [14,19,22]. However, another possible caveat concerns the criteria for selecting patient samples.…”

Section: Introductionmentioning

confidence: 99%

“…Whereas the CA3 region displays a high proportion of reverberating neural connectivity, the CA1 region displays fewer such recurrent connections and, together with the subiculum, constitutes the main output region of the HP [15,16,17,18]. The CA2-3 region in combination with the subiculum and presubiculum has been reported to be atrophic in aMCI relative to controls [19,20]. In contrast, a recent study utilizing 7-tesla MR images and manual delineation of HP subfields did not find significant volume differences to any subfields or ERC in MCI, but significant volume differences between early-stage AD versus controls, and early-stage AD versus MCI in most HP subfields, including the ERC [21].…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal Subfield Atrophy in Multi-Domain but Not Amnestic Mild Cognitive Impairment

Eliassen

Selnes

Almdahl

et al. 2015

Dement Geriatr Cogn Disord

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Background/Aims: To investigate differences in hippocampal (HP) subfields and the adjoining perirhinal and entorhinal cortices (PRC and ERC) between amnestic mild cognitive impairment (aMCI) and multi-domain amnestic MCI (mdMCI) patients, and controls. Methods: Nineteen patients characterized as aMCI were compared with 24 mdMCI patients and 31 controls by means of an automatic HP segmentation procedure. Results: We found significant atrophy of the PRC and ERC in aMCI relative to controls, whereas a more pronounced pattern of atrophy in most subfields, including total HP volume, was found in the mdMCI group. The mdMCI group also had a significant cornu ammonis sector 4 region with dentate gyrus, subiculum and total HP atrophy relative to aMCI. Conclusion: The aMCI group showed atrophy in the PRC and ERC, whereas significantly more affection of the HP subfields was evident in mdMCI. The mdMCI group may thus represent clinical progression relative to aMCI coupled with HP subfield affection.

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Connectome-scale assessments of structural and functional connectivity in MCI

Zhu

Terry

et al. 2013

Hum. Brain Mapp.

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Mild cognitive impairment (MCI) has received increasing attention not only because of its potential as a precursor for Alzheimer's disease (AD), but also as a predictor of conversion to other neurodegenerative diseases. Although MCI has been defined clinically, accurate and efficient diagnosis is still challenging. While neuroimaging techniques hold promise, compared to commonly-used biomarkers including amyloid plaques, tau protein levels and brain tissue atrophy, neuroimaging biomarkers are less well validated. In the present paper, we propose a connectomes-scale assessment of structural and functional connectivity in MCI via two independent multimodal DTI/fMRI datasets. We first used DTI-derived structural profiles to explore and tailor the most common and consistent landmarks, then applied them in a whole-brain functional connectivity analysis. The next step fused the results from two independent datasets together and resulted in a set of functional connectomes with the most differentiation power, hence named as “connectome signatures”. Our results indicate that these “connectome signatures” have significantly high MCI-vs-controls classification accuracy, at more than 95%. Interestingly, through functional meta-analysis, we found that the majority of “connectome signatures” are mainly derived from the interactions among different functional networks, e.g., cognition-perception and cognition-action domains, rather than from within a single network. Our work provides support for using functional “connectome signatures” as neuroimaging biomarkers of MCI.

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Mild Cognitive Impairment: Differential Atrophy in the Hippocampal Subfields

Cited by 102 publications

References 16 publications

Regional Hippocampal Volumes and Development Predict Learning and Memory

Regional Hippocampal Volumes and Development Predict Learning and Memory

Hippocampal Subfield Atrophy in Multi-Domain but Not Amnestic Mild Cognitive Impairment

Connectome-scale assessments of structural and functional connectivity in MCI

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