Mild cognitive impairment in prediagnosed Huntington disease

Computational Investigations of Cognitive Impairment in Huntington's Disease

“…The choice of using memory cues is voluntary and thus an individual (e.g., no strategy user) may be classified as amnestic at an early stage and nonamnestic at a later time. This is possible explanation for the erratic pattern presented in Duff, et al (2010).…”

“…The division of mild cognitive impairment in pHD into an amnestic and a nonamnestic variant Duff et al (2010) would map onto those who do and those who do not attempt memory strategies. In addition, the choice of using a memory strategy is unlikely to involve any components that are measured using the UHDRS Motor Score.…”

“…In the verbal learning test, not being able to disengage from a cue will limit the total recall performance and thus pHD should show selective memory impairment. Duff et al (2010) discuss the possibility of dividing pHD into an amnestic and a nonamnestic group. The measure used to distinguish this is the total recall on the HVLT together with scores from other tasks, with subnormal performance on any non-memory resulting in a nonamnestic categorization.…”

“…Cognitive decline is present years before the clinical manifestation of HD. In a recent report, the term "mild cognitive impairment" in preclinical HD (pHD) was advocated with an amnestic and nonamnestic variant (Duff, et al, 2010). Considerable effort is invested in identifying which combinations of neuropsychological tests have high clinical utility.…”

Mental disorders in Huntington’s disease

“…По мнению A. Rosenblatt [24], ошибочно думать, что когнитивные и нейропсихиатри-ческие расстройства при БГ являются «вторичными» по отно-шению к моторным проявлениям. Как показано многими ав-торами [25][26][27], легкие когнитивные и личностные наруше-ния (в частности, депрессия) могут наблюдаться у носителей мутантного гена БГ за много лет до дебюта моторных прояв-лений заболевания. Не подтвердилась и бытовавшая ранее точка зрения, что психиатрические синдромы (аффективные расстройства, в том числе депрессия, мании и биполярные нарушения, обсессивно-компульсивные расстройства, пара-нойя и т.…”