Milk Fever: Reductionist Versus Systems Veterinary Approach

Dervishi, Elda; Ametaj, Burim N.

doi:10.1007/978-3-319-43033-1_12

Cited by 1 publication

(1 citation statement)

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“…Of particular interest, Sasaki et al (2014) investigated gene expression of peripheral blood mononuclear cells in milk fever vs. healthy cows. Notably, upregulated genes were involved in regulation of protein amino acid phosphorylation, intracellular signaling cascade, apoptosis, and cell death, while downregulated genes were implicated in cation-binding, transcription regulation, and DNA-binding ( Sasaki et al, 2014 ; Dervishi and Ametaj, 2017 ). Therefore, our results provide further evidence that processes such as protein phosphorylation and regulation of apoptosis, among others, could be implicated in the development of periparturient hypocalcemia in dairy cows.…”

Section: Resultsmentioning

confidence: 99%

Gene Mapping and Gene-Set Analysis for Milk Fever Incidence in Holstein Dairy Cattle

et al. 2018

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Milk fever is an important metabolic disorder that affects dairy cows around parturition. It is associated with a breakdown in the mechanisms of calcium homeostasis, resulting in very low blood calcium levels (hypocalcemia). The main objective of this study was to dissect the genetic basis underlying milk fever incidence in Holstein cattle. Data consisted of 31.6 k producer-recorded lactation incidence records from 15.3 k cows. The analysis included a whole-genome scan and a subsequent gene-set analysis in order to reveal individual genes, genetic mechanisms and biological pathways implicated in the incidence of periparturient hypocalcemia. The association analysis identified at least eight different genomic regions that explain considerable amounts of additive genetic variance for milk fever incidence. Notably, some of these regions harbor genes, such as CYP27A1, CYP2J2, GC, SNAI2, and PIM1, that are directly involved in vitamin D metabolic pathway. Moreover, the gene-set analysis revealed several functional terms, such as calcium ion binding, calcium ion transportation, T cell differentiation, B cell activation, protein phosphorylation, apoptosis, and protein kinase activity, among others, that could be implicated in the development of periparturient hypocalcemia. Overall, this comprehensive study contributes to a better understanding of the genetic control of this complex disease. In addition, these findings may contribute to the development of novel breeding strategies for reducing the incidence of milk fever in dairy cattle.

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Section: Resultsmentioning

confidence: 99%