Milk kinetics of moxidectin and doramectin in goats

Cárceles, C. M.; Diaz, M.S; Vicente, Marı́a Soledad; Sutra, J.F.; Alvinerie, M.; Escudero, Elisa

doi:10.1053/rvsc.2001.0463

Cited by 24 publications

(26 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moxidectin alone or in combination with other medication has been successfully used in the treatment of sheep [10, 25], cattle [27], horses [28], dogs, and rabbits [20, 29] affected with sarcoptic mange. In dairy farms, this treatment is not advisable during the milking period, because moxidectin is a lipophilic molecule and much of it is excreted into the milk [30]. However, in the severely affected goat herd of this paper this was not a problem, as the milk production had reached a minimal level, and the collected milk had been discarded during the 8-week trial with moxidectin.…”

Section: Discussionmentioning

confidence: 99%

Moxidectin Efficacy in a Goat Herd with Chronic and Generalized Sarcoptic Mange

Giadinis

Farmaki²,

Papaioannou³

et al. 2011

Veterinary Medicine International

View full text Add to dashboard Cite

A case of sarcoptic mange affecting almost all the animals of a dairy goat herd is described. This pruritic skin disease led progressively to high mortality and dramatic drop of milk yield. The lesions of the affected goats were typical of a chronic and generalized-diffuse sarcoptic mange. Diagnosis was confirmed by skin scrapings and histopathology in which many mites were demonstrated. All surviving goats were treated with injectable moxidectin solution 1% (CYDECTIN-Fort Dodge) at the dose of 0.2 mg/kg, applied every 15 days for four times, subcutaneously. Although pruritus had decreased soon after the first treatment, a satisfactory healing of cutaneous lesions was witnessed 6 weeks after the beginning of moxidectin trial. Parasitological cure was achieved in all affected animals by the end of the trial. In the four monthly followups, no evidence of sarcoptic mange could be found.

show abstract

Section: Discussionmentioning

confidence: 99%

Moxidectin Efficacy in a Goat Herd with Chronic and Generalized Sarcoptic Mange

Giadinis

Farmaki²,

Papaioannou³

et al. 2011

Veterinary Medicine International

View full text Add to dashboard Cite

show abstract

“…Indeed, moxidectin is much more lipophilic than ivermectin and is mainly stored in fat [14]. This appears to have an accumulatory effect and results in a long mean residence time for the drug in the body, as it has been widely demonstrated in cows [15], in sheep [16], in goats [17], in horses [18] and in water buffaloes [14]. …”

Section: Discussionmentioning

confidence: 99%

The effect of moxidectin 0,1% vs ivermectin 0,08% on milk production in sheep naturally infected by gastrointestinal nematodes

et al. 2009

View full text Add to dashboard Cite

BackgroundGastrointestinal nematode (GIN) infection is one of the main constraints to sheep production both in temperate and tropical countries. Economic losses caused by GIN are related to decreased production, treatment costs and even animal death. The present paper was aimed at assessing the anthelmintic efficacy (based on faecal egg count reduction) of moxidectin and ivermectin both admistered per os at dose rate of 0.2 mg/Kg body weight and the benefit of anthelmintic treatments on milk production in a commercial dairy sheep farms in central Italy whose animals were naturally infected by GIN.ResultsThe treatment with moxidectin was highly effective (> 98%) from day 7 until day 75, and effective (90-98%) until day 105. The treatment with ivermectin was highly effective (> 98%) from day 7 until day 14, effective (90-98%) at day 28 and moderately effective (80-89%) on day 45. The milk productions in the treated groups were significantly higher than those of the control group.ConclusionIn conclusion, the results of the present study demonstrated that moxidectin and ivermectin adminstered per os according to the manufacturer's instructions were both effective and safe anthelmintics in sheep. The total milk production was higher in the treated groups than the control group. Overall, animals treated with moxidectin had a milk production 40.8% higher than control group; whereas animals treated with ivermectin had a milk production 32.2% higher than control group.

show abstract

“…Patterns of excretion in milk for IVM (Toutain et al 1988;Cerkvenik et al 2002) and MXD (Alvinerie et al 1996;Carceles et al 2001) have been characterized in different species. Pour-on formulations (0 .…”

mentioning

confidence: 99%

Comparative depletion of ivermectin and moxidectin milk residues in dairy sheep after oral and subcutaneous administration

Imperiale

Lifschitz

Sallovitz

et al. 2004

Journal of Dairy Research

View full text Add to dashboard Cite

Ivermectin (IVM) and moxidectin (MXD) are broad-spectrum endectocides belonging to the avermectin/milbemycin class of antiparasitic drugs not approved for use in dairy sheep. However, these compounds are widely used extra-label to control endo-and ecto-parasites in lactating dairy sheep. Effects of the route of administration on the pattern of IVM and MXD excretion in milk were comparatively characterized in lactating dairy sheep. The relationship between the milk and plasma disposition kinetics after subcutaneous (s.c.) and oral administration at 200 mg/kg body weight was also evaluated. IVM and MXD concentration profiles were measured in milk and plasma using a specific HPLC-based methodology. IVM and MXD were extensively distributed from the bloodstream to the mammary gland and large quantities, particularly for MXD, were excreted in milk. Residual concentrations of IVM were recovered in milk up to 11 d (oral treatment) or 25 d (s.c. treatment) post treatment. However, high MXD concentrations were detected in milk between 1 h and 35 d after its oral and subcutaneous administration. MXD concentrations as high as 3 . 77 ng/ml (oral) and 30 . 3 ng/ml (s.c.) were measured in milk at day 35 post administration. A higher MXD excretion in milk, compared with that of IVM, was obtained for both administration routes. An extensive plasma to milk distribution pattern was observed, being the area under the concentration-time curve of MXD obtained in milk up to 14-fold higher than that measured in the bloodstream. The total fraction of the administered dose excreted in milk for MXD was significantly higher than that for IVM, which agrees with the well known higher MXD lipophilicity. The long persistence of milk residual concentrations of MXD and IVM in lactating dairy sheep should be seriously considered before their extra-label use is recommended.

show abstract

Milk kinetics of moxidectin and doramectin in goats

Cited by 24 publications

References 16 publications

Moxidectin Efficacy in a Goat Herd with Chronic and Generalized Sarcoptic Mange

Moxidectin Efficacy in a Goat Herd with Chronic and Generalized Sarcoptic Mange

The effect of moxidectin 0,1% vs ivermectin 0,08% on milk production in sheep naturally infected by gastrointestinal nematodes

Comparative depletion of ivermectin and moxidectin milk residues in dairy sheep after oral and subcutaneous administration

Contact Info

Product

Resources

About