Milk Thistle Seed Extract Favorably Affects Lactation and Development of Mammary Gland in Female Rats

Mohammad, Bassim I; AL-Zamely, Hayder A.N.; Gharrawi, Firas Al; Al-Aubaidy, Hayder A.

doi:10.21608/ejvs.2018.6754.1058

Cited by 4 publications

(7 citation statements)

References 23 publications

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“…According to milk production (Table 3), rabbits of T4 fed the highest level of MTE (9 ml) T4 group recorded significantly the best milk yield during the first 4 weeks after delivering bunnies, while at last week of lactation (fifth week) this improvement was disappeared. These results are in agreement with Mohammad et al (2019) who reported that silymarin increased the activity of mammary gland and thus milk production in female rats. There are several reviews speculated that milk thistle seed stimulate milk production as tested in rats (Capasso et al, 2009) and dairy cow (Tedesco et al, 2004).…”

Section: Discussionsupporting

confidence: 93%

“…The improvement in weaning weight of bunnies may be due to increasing in milk yield as reported previously in Table (3). These results agree with Mohammad et al (2019) who concluded that feeding silymarin in female rats improved significantly their litter weight as a result of increasing milk production. Although there is a gradual increase in serum AST and ALT values in does fed gradual level of MTE, the differences were none significant and values were within normal rage (Table 5).…”

Section: Discussionsupporting

confidence: 92%

“…Group of 6MTE and 9MTE achieved significantly higher litter weight compared to control and 3MTE groups. These results confirm the latest research of Mohammad et al (2019) who documented that feeding female rat with 200 mg\kg\day of milk thistle extract resulted in higher litter weight at birth compared to control. According to milk production (Table 3), rabbits of T4 fed the highest level of MTE (9 ml) T4 group recorded significantly the best milk yield during the first 4 weeks after delivering bunnies, while at last week of lactation (fifth week) this improvement was disappeared.…”

Section: Discussionsupporting

confidence: 90%

“…Pituitary gland activate the secretion of prolactin hormone which in term increases two functions of the mammary glands such as the growth during pregnancy then stimulate of milk production during nursing infants (Ben-Jonathan et al, 2006). Recently, Mohammad et al (2019) concluded that silymarin (which has galactogenic properties), increased serum prolactin levels in female rats during pregnancy and lactation.…”

Section: Discussionmentioning

confidence: 99%

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IMPACT OF DIETARY SUPPLEMENTATION OF MILK THISTLE (Silybum marianum) SEED EXTRACT ON DOE RABBITS PERFORMANCE

Refaie

Ghazal

El-Azayem

et al. 2019

Egyptian Journal of Nutrition and Feeds

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ilk thistle seed extract consists mainly of flavonolignans, which include silybin (silibinin), sylichrisitn, and silydianin that commonly referred to Silymarin. A total number of thirty six, 9-10 month old New-Zealand white muliparous does, with an average weight of 3641g ± 94.02 were used to evaluate the response to dietary supplementation with ethanolic milk thistle extract (MTE) containing 70% silymarin on some performance aspects during pregnancy and lactation periods. Does were allocated to 4 experimental groups, 9 does of each. Rabbits were fed the experimental diets started one month before first mating. Does were allowed to the following treatments; a control group was fed a basal diet without MTE (T1), then the 2 nd , 3 rd , and 4 th were fed the basal diet supplemented with 3ml, 6ml or 9ml MTE/kg diet, respectively and abbreviated as 3MTE (T2), 6MTE (T3) and 9MTE (T4), respectively. The trail was ended after pregnant period and nursering kits till weaning. The results indicate that feed intake during pregnancy (except T2) and lactation , litter weight at birth and weaning (except T2) were significantly (P≤0.05) increased by supplementing does diets with MTE at 6 or 9ml/kg diet compared to the control. Also, litter size at birth and litter size at weaning (except T2) were significantly (P≤0.05) higher with MTE supplementation compared to the control. Milk production significantly (P≤0.05) was the highest in 9MTE group for the first four weeks compared with the control. Plasma prolactin hormone was significantly (P≤0.05) improved gradually by enriched does diet with MTE, but liver enyzmes (AST & ALT) was insignificantly higher in all MTE groups compared to the control. It could be concluded that adding milk thistle seed extract to does diets enhanced their performance during gestation and lactation periods, in term of increased their milk production and litter weight at birth and weaning.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

IMPACT OF DIETARY SUPPLEMENTATION OF MILK THISTLE (Silybum marianum) SEED EXTRACT ON DOE RABBITS PERFORMANCE

Refaie

Ghazal

El-Azayem

et al. 2019

Egyptian Journal of Nutrition and Feeds

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“…Findings demonstrate that progesterone levels are declining whereas estrogen levels are significantly gained in postnatal treated groups with Silymarin in treated group comparison to control group (p 0.05) (Figure 1). This work supports the findings of (16,17,18) showing prolactin significantly increase and has a variety of functions, including maintaining mammary gland production, acting in tandem with androgens, and affecting androgen metabolic activity. Furthermore, many studies have found that oral administration of aqueous extracts of medicinal herbs causes a considerable drop in progesterone levels, which is consistent with our findings (19).…”

Section: Reproductive Hormonessupporting

confidence: 90%

Role of silymarin on the some serum sex hormones and oxidant\ antioxidant parameters in during Lactation period on female rats

Jawad¹,

Albazi²,

Mahmood³

2022

ijhs

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Objective: To see how dosage of Silymarin effect on some serum prolactin ,estrogen and progesterone and some oxidant\ antioxidant in serum samples of female experimental rats throughout nursing. Methods: Twenty-four adult healthy, pregnant rats were divided into two groups (12rats/group) and treated as follows for ten days. G 1 were intubated orally distal water serving as control while, G 2 were intubated orally Silymarin (200 mg\kg\day), the following criteria were measured serum prolactin, estrogen, progesterone hormones, GSH, MDA, SOD and CAT. Results: The findings show that Silymarin had a significant increase influence in serum prolactin, estrogen hormone, SOD, CAT, MDA and a significant decrease in Progesterone and GSH. Conclusion: The focus of this study mention a new evidence of the role of Silymarin on the increasing prolactin, estrogen & progesterone hormones hormone and effect on some level of oxidant\ antioxidant.

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Ethnopharmacology of Botanical Galactagogues and Comprehensive Analysis of Gaps Between Traditional and Scientific Evidence

Thakur,

Khedkar,

Singh

et al. 2023

Curr Res Nutr Food Sci

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The functional potential of plants and plant-based components have been used in different cultures since time immemorial to promote milk production in women. Conditions like agalactia or insufficient production of breast milk due to various barriers intended to be a greater risk of weight loss for neonates and prompting for supplementation of infant formula. Multiple plants are traditionally used worldwide as galactagogues during the lactation period. This study aims to extract information on traditionally used galactagogue plants and compare their ethnopharmacological evidence with scientific evidence. This will help to understand the gaps in the ethnopharmacological and scientific data and thus provide future research information.Information on traditional and scientific studies was collected and analyzed on galactagogues. The ethnopharmacological data of the focused plant species were analyzed for part used, formulations, and region of its uses. All cultures traditionally used natural products as galactagogue from times immemorial, and due to scientific advances, these have also been seen as commercial products. However, because of the limited studies, it is of interest to standardize the doses, and composition of bioactive components and study the mechanism of action, its side effects, and interaction with food. This is a forward-looking research area that could be projected for manufacturing herbal formulations for lactating mothers.

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Milk Thistle Seed Extract Favorably Affects Lactation and Development of Mammary Gland in Female Rats

Cited by 4 publications

References 23 publications

IMPACT OF DIETARY SUPPLEMENTATION OF MILK THISTLE (Silybum marianum) SEED EXTRACT ON DOE RABBITS PERFORMANCE

IMPACT OF DIETARY SUPPLEMENTATION OF MILK THISTLE (Silybum marianum) SEED EXTRACT ON DOE RABBITS PERFORMANCE

Role of silymarin on the some serum sex hormones and oxidant\ antioxidant parameters in during Lactation period on female rats

Ethnopharmacology of Botanical Galactagogues and Comprehensive Analysis of Gaps Between Traditional and Scientific Evidence

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