Mineralization potential of cellulose-nanofibrils reinforced gelatine scaffolds for promoted calcium deposition by mesenchymal stem cells

The Effect of Membrane Structure Prepared from Carboxymethyl Cellulose and Cellulose Nanofibrils for Cationic Dye Removal

“…The FTIR spectral data ( Fig. 1) of the solvent-casted CNF/CMC membranes demonstrate typical spectral lines for CNF [36], CMC and CA [37]. In brief, band ~ 900 cm −1 (in CMC and CNF) and 1742.3 cm −1 (in anhydrous CA) are assigned to ether (C-O-C) stretch vibration, the 1000-1070 cm −1 is region of primary (~ 1030 cm −1 ) and secondary (~ 1055 cm −1 ) alcohols, the 3600-3000 cm −1 is O-H vibrations region, etc.…”

Internalization of (bis)phosphonate-modified cellulose nanocrystals by human osteoblast cells

“…In the case of ApA-conjugated CNCs (CNCoxApA), the inflection point at pH 5 and the slope of the curve by further increasing of pH, imply indirectly on the presence of ApA in which the secondary amine group (resulting from Shiff-base reaction) is getting protonated. Its' zeta-potential is increased up to −52.6 ± 11 mV at pH 11, which is attributed to different ionization of phosphonate groups present in ApA (pH7 \ pKa \ pH9) (Gorgieva et al 2017), as well as sulphate and carboxylic groups present on CNC (pH5 \ pKa \ pH7). Cellulose (2017) 24:4235-4252 4243 Moreover, the net positive charge of RBITC decreases the negative zeta-potential additionally in all RBITC-labelled CNCs, thus providing an additional evidence for RBITC attachment on the CNC surface.…”

“…2b) although following the same trend. It was demonstrated previously that ApA modification of cellulose nanofibers (CNFs) induces their aggregation (Gorgieva et al 2017) which is related to the molecular structure of ApA, i.e. the presence of a single phosphonate group anchored on a hydrophobic tail.…”

“…in combination with bioglass), have been shown to be suitable as orthopaedic materials. Such CNC-based hybrid materials can accelerate osteoblast attachment, increase their spreading, proliferation, even promote differentiation of mesenchymal cells towards the osteoblast like phenotype (Gorgieva et al 2017), as well as influence mineralization of the native osteoblast extracellular matrix positively (Chen et al 2015). Nevertheless, neither of these studies reports or even considers the internalization of materials (or their parts) by osteoblasts.…”

“…Nanocellulose (NC) has also gained significant attention in pharmaceutical and biomedical applications recently, above all in wound healing (Napavichayanun et al 2016), tissue engineering (Gorgieva et al 2017;Markstedt et al 2015;Brown et al 2013), cell therapy (Lou et al 2014), gene (Ndong Ntoutoume et al 2017), drug delivery (Barbosa et al 2016;Dong et al 2014;Villanova et al 2011;Lin et al 2016), and diagnostics (Edwards et al 2016). Such a wide application spectrum is related mainly to their nanometer-sized features, large surface area, specific biomechanical characteristics, surface chemistry, ease of conjugation, high biocompatibility, and low (if any) cytotoxicity (Alexandrescu et al 2013) with tolerogenic potential to the immune system (Tomić et al 2016).…”