Minocycline Inhibits &lt;i&gt;Candida albicans&lt;/i&gt; Budded-to-Hyphal-Form Transition and Biofilm Formation

Kurakado, Sanae; Takatori, Kazuhiko; Sugita, Takashi

doi:10.7883/yoken.jjid.2016.369

Cited by 17 publications

(13 citation statements)

References 41 publications

(37 reference statements)

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“…The microbial adhesion to hydrocarbons (MATH) assay is a common method for determining CSH in fungi (Borecka-Melkusováand Bujdaḱova, 2008;Ellepola et al, 2013a;Galań-Ladero et al, 2013;Rajkowska et al, 2015;Sivasankar et al, 2015;Ichikawa et al, 2017;Kurakado et al, 2017;Souza et al, 2018;Angiolella et al, 2020;Ramos et al, 2020;Suchodolski et al, 2020). This assay measures the decrease in culture density of an aqueous solution after thorough mixing with, and separation of, a hydrocarbon layer.…”

Section: Methods For Measurement Of Cshmentioning

confidence: 99%

“…Minocycline, a tetracycline derivative, was active against the budded-to-hyphal-form transition of C. albicans at sub-growth inhibitory concentrations (Kurakado et al, 2017). This transition is necessary for full virulence and for biofilm formation.…”

Section: Response To Antifungal Treatmentsmentioning

confidence: 99%

“…Cells with higher CSH prefer a hydrophobic environment while those with lower CSH will preferentially remain in an aqueous environment (Krasowska and Sigler, 2014). This property can impact fungal virulence and biofilm formation (Galań-Ladero et al, 2013;Muadcheingka and Tantivitayakul, 2015;Dabiri et al, 2018) and is targeted by numerous antifungal drugs (Sivasankar et al, 2015;Kurakado et al, 2017;Suchodolski et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Role of Cell Surface Hydrophobicity in the Pathogenesis of Medically-Significant Fungi

Danchik

Casadevall

2021

Front. Cell. Infect. Microbiol.

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Cell surface hydrophobicity (CSH) is an important cellular biophysical parameter which affects both cell-cell and cell-surface interactions. In dimorphic fungi, multiple factors including the temperature-induced shift between mold and yeast forms have strong effects on CSH with higher hydrophobicity more common at the lower temperatures conducive to filamentous cell growth. Some strains of Cryptococcus neoformans exhibit high CSH despite the presence of the hydrophilic capsule. Among individual yeast colonies from the same isolate, distinct morphologies can correspond to differences in CSH. These differences in CSH are frequently associated with altered virulence in medically-significant fungi and can impact the efficacy of antifungal therapies. The mechanisms for the maintenance of CSH in pathogenic fungi remain poorly understood, but an appreciation of this fundamental cellular parameter is important for understanding its contributions to such phenomena as biofilm formation and virulence.

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Section: Methods For Measurement Of Cshmentioning

confidence: 99%

Section: Response To Antifungal Treatmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of Cell Surface Hydrophobicity in the Pathogenesis of Medically-Significant Fungi

Danchik

Casadevall

2021

Front. Cell. Infect. Microbiol.

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“…Haque et al [27] found that sophorolipid (SL) downregulated the expression of hyphae-specific genes including ECE1, and this possibly explains the inhibitory effect of SL on hyphae and biofilm formation. Kurakado et al [28] concluded that minocycline decreased the expression of hyphae-specific genes HWP1 and ECE1, inhibiting the C. albicans yeast-to-hyphae transition. [28] Furthermore, during the immunoactivation triggered by candidalysin, morphology-dependent host FGF-2 signaling [21] and EGFR [29] can also be potential therapeutic targets.…”

Section: The Potential Of Candidalysin As a Diagnostic Biomarker As Wmentioning

confidence: 99%

“…Kurakado et al [28] concluded that minocycline decreased the expression of hyphae-specific genes HWP1 and ECE1, inhibiting the C. albicans yeast-to-hyphae transition. [28] Furthermore, during the immunoactivation triggered by candidalysin, morphology-dependent host FGF-2 signaling [21] and EGFR [29] can also be potential therapeutic targets. Said et al [30] demonstrated that garlic can alter the expression of putative virulence factor genes SIR2 and ECE1 in vulvovaginal C. albicans isolates, suggesting a possible mechanism of phytotherapy with garlic.…”

Section: The Potential Of Candidalysin As a Diagnostic Biomarker As Wmentioning

confidence: 99%

Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response

Chen

Zhang

et al. 2020

Innovations in Digital Health, Diagnostics, and Biomarkers

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The incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the transition between yeast and hyphae is critical for C. albicans virulence and pathogenesis. However, the mechanism of hyphae-associated virulence remains unclear. Candidalysin is the first human fungal cytolytic peptide toxin originating from the hyphae-specific gene, ECE1. This review will summarize the most recent progress underlying candidalysin-mediated epithelial damage and host defense pathways, which might shed new light on the development of a novel antifungal strategy and early diagnostic biomarker.

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Surviving the Storm: How Candida Species Master Adaptation for Pathogenesis

Rana,

Gupta,

Asif

et al. 2024

Recent Advances in Human Fungal Diseases

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Minocycline Inhibits <i>Candida albicans</i> Budded-to-Hyphal-Form Transition and Biofilm Formation

Cited by 17 publications

References 41 publications

Role of Cell Surface Hydrophobicity in the Pathogenesis of Medically-Significant Fungi

Role of Cell Surface Hydrophobicity in the Pathogenesis of Medically-Significant Fungi

Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response

Surviving the Storm: How Candida Species Master Adaptation for Pathogenesis

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