miR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma

Nezu, Yutaka; Hagiwara, Kenta; Yamamoto, Yusuke; Fujiwara, Toshiyoshi; Matsuo, Kazuya; Yoshida, Akihiko; Kawai, Akira; Saito, T.; Ochiya, Takahiro

doi:10.1038/onc.2016.157

Cited by 47 publications

(39 citation statements)

References 57 publications

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“…Images were acquired with a microscope (BZ-X710; Keyence Corporation, Osaka, Japan). To analyze the image of a whole lung, partial lung images were combined using BZ-X analyzer software (Keyence), and the percentage of the whole lung composed of hypercellular areas associated with infiltration of inflammatory cells was determined using BZ-X analyzer software as described previously [33,34].…”

Section: Histological Analysismentioning

confidence: 99%

IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle

et al. 2016

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Severe influenza is characterized by a cytokine storm, and the influenza virus–cytokine–trypsin cycle is one of the important mechanisms of viral multiplication and multiple organ failure. The aim of this study was to define the key cytokine(s) responsible for trypsin upregulation. Mice were infected with influenza virus strain A/Puerto Rico/8/34 (H1N1) or treated individually or with a combination of interleukin-1β, interleukin-6, and tumor necrosis factor α. The levels of these cytokines and trypsin in the lungs were monitored. The neutralizing effects of anti-IL-1β antibodies on cytokine and trypsin expression in human A549 cells and lung inflammation in the infected mice were examined. Infection induced interleukin-1β, interleukin-6, tumor necrosis factor α, and ectopic trypsin in mouse lungs in a dose- and time-dependent manner. Intraperitoneal administration of interleukin-1β combined with other cytokines tended to upregulate trypsin and cytokine expression in the lungs, but the combination without interleukin-1β did not induce trypsin. In contrast, incubation of A549 cells with interleukin-1β alone induced both cytokines and trypsin, and anti-interleukin-1β antibody treatment abrogated these effects. Administration of the antibody in the infected mice reduced lung inflammation area. These findings suggest that IL-1β plays a key role in trypsin upregulation and has a pathological role in multiple organ failure.

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Section: Histological Analysismentioning

confidence: 99%

IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle

et al. 2016

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“…miRNA also inhibit the translation or facilitate the cleavage of their target mRNA by binding to their CDS . To date, multiple miRNA have been identified in various types of cancers, and these tumor‐associated miRNA can be classified into two groups: TS‐miRNA and onco‐miRNA …”

Section: Introductionmentioning

confidence: 99%

Development of miRNA‐based therapeutic approaches for cancer patients

Takahashi

Prieto‐Vila

Kohama³

et al. 2019

Cancer Science

109

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Over the past few decades, si RNA and mi RNA have attracted a great deal of attention from researchers and clinicians. These molecules have been extensively studied from the standpoint of developing biopharmaceuticals against various diseases, including heart disease, diabetes and cancers. si RNA suppresses only a single target, whereas each mi RNA regulates the expression of multiple target genes. More importantly, because mi RNA are also secreted from cancer cells, and their aberrant expression is associated with tumor development and progression, they represent not only therapeutic targets but also promising biomarkers for diagnosis and prognosis. Therefore, mi RNA may be more effective tools against cancers, in which multiple signal pathways are dysregulated. In this review, we summarize recent progress in the development of mi RNA therapeutics for the treatment of cancer patients, and describe delivery systems for oligonucleotide therapeutics.

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“…A review of survival data from the literature indicates that several clinico-morphological factors such as tumour size, histologic subtype [2], and grading [2,3] or even selected molecular changes [4,5,6,7] may significantly affect disease-free or/and overall survival of LPS patients.…”

Section: Introductionmentioning

confidence: 99%

The role of histology, grading, location of tumour and ploidy in evaluation of outcome in patients with liposarcoma

Harazin-Lechowska¹,

Ambroziak-Lackowska²,

Ryś³

et al. 2017

pjp

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The review of literature indicates that several clinico-morphological factors such as location of the primary tumour as well as its size, histologic subtype, and grade or even selected molecular changes may significantly affect survival of liposarcoma (LPS) patients. Data concerning prognostic importance of DNA ploidy status in LPS cells are extremely limited and results of flow cytometry (FCM) studies have never been compiled with the current classification of malignant adipocytic tumours. Based on evaluation of material from 54 liposarcomas which was available for both histological and FCM analysis, we distinguished four prognostic groups of patients. The best prognosis was noticed for diploid and grade G1 well-differentiated or myxoid liposarcomas localised on extremities. None of the patients with lipoma-like WDLPS and myxoid liposarcoma grade 1 metastasised, while metastases were observed among patients with dedifferentiated LPS (70% of 5-year MFS) and cellular myxoid or round cell liposarcoma (20% of 5-year MFS, only). The metastasis-free survival curves for the above mentioned groups of patients differed significantly (p = 0.00001)

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miR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma

Cited by 47 publications

References 57 publications

IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle

IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle

Development of miRNA‐based therapeutic approaches for cancer patients

The role of histology, grading, location of tumour and ploidy in evaluation of outcome in patients with liposarcoma

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